INT46142

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.19
First Reported 1983
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 16.40
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Chka) cytoplasm (Chka)
Anatomy Link Frequency
covering 1
GPI 1
epithelial cell 1
T cell 1
hematopoietic cells 1
Chka (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 16 100.00 Very High Very High Very High
antidepressant 5 95.48 Very High Very High Very High
anesthesia 30 78.48 Quite High
tail-flick 1 78.32 Quite High
analgesia 1 76.64 Quite High
Endep 1 73.92 Quite High
Serotonin 1 60.88 Quite High
fluoxetine 1 57.60 Quite High
corticosteroid 12 51.80 Quite High
antagonist 5 48.80 Quite Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 132 100.00 Very High Very High Very High
Carcinoma 240 99.84 Very High Very High Very High
Plasmacytoma 8 99.76 Very High Very High Very High
Cancer 974 99.52 Very High Very High Very High
Adhesions 75 99.30 Very High Very High Very High
Disease 358 99.28 Very High Very High Very High
Hodgkin's Disease 100 99.08 Very High Very High Very High
Breast Cancer 570 99.04 Very High Very High Very High
Lymphatic System Cancer 488 98.56 Very High Very High Very High
Leukemia 28 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All four analogs were less active than Met-enkephalin (Met-EK) as shown by relative potencies in the guinea pig ileum (GPI) assay: Met-EK, 100; [Phe5]-EK-NH2, 59; [Trp5]-EK-NH2, 11; Met-EK-Cys(Cam)-OH, 37; and N,N'-bis(Met-EK)-cystine, 34.
Gene_expression (active) of Met-EK in GPI associated with enkephalin
1) Confidence 0.19 Published 1983 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6862764 Disease Relevance 0 Pain Relevance 1.36
Indeed, we showed here and elsewhere [16] that EpCAM-positive BM cells may or may not express CK.
Neg (not) Gene_expression (express) of CK
2) Confidence 0.17 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.47 Pain Relevance 0
Besides the difference in sensitivity due to different enrichment protocols, we suggest that both methods may detect different tumor cell subpopulations that differentially express the CK and EpCAM antigens.
Gene_expression (express) of CK associated with cancer
3) Confidence 0.17 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.58 Pain Relevance 0
As exemplified by immunofluorescence experiments (Fig. 4a), EpCAM-positive BM carcinoma cells may or may not express CK, reinforcing the idea that two different pools of carcinoma cells may be detected by the IM and the IC techniques.
Neg (not) Gene_expression (express) of CK associated with carcinoma
4) Confidence 0.17 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.67 Pain Relevance 0
Our assumption is based on the evaluation of A45-B/B3 immunostaining in primary tumor tissues for a set of ductal or lobular invasive carcinoma patients, which demonstrated large variations in CK expression (data not shown).
Gene_expression (expression) of CK associated with cancer and carcinoma
5) Confidence 0.17 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.93 Pain Relevance 0
Moreover, anti-CK immunohistochemistry performed on primary tumor specimens from patients demonstrated the large heterogeneity in CK expression on carcinoma cells (data not shown).
Gene_expression (expression) of CK associated with cancer and carcinoma
6) Confidence 0.17 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.80 Pain Relevance 0
We also show that IC detection of CK-positive cells for the same patient population is not correlated to the stage of disease.
Gene_expression (detection) of CK associated with disease
7) Confidence 0.15 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.87 Pain Relevance 0
False-positive immunostaining of hematopoietic cells and CK-expressing BM cells may thus interfere with the IC detection of micrometastatic cells in patient BM.
Gene_expression (expressing) of CK in hematopoietic cells
8) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.35 Pain Relevance 0
For both techniques, we assessed the contamination of the final fraction with BM cells and the heterogeneity of the pattern of epithelial cell adhesion molecule (EpCAM) and cytokeratin (CK) marker expression.


Gene_expression (expression) of CK in epithelial cell associated with adhesions
9) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.93 Pain Relevance 0.15
Another explanation could be the heterogeneity of expression of markers such as CK and EpCAM in carcinoma cells.
Gene_expression (expression) of CK associated with carcinoma
10) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.59 Pain Relevance 0
Ten out of the 32 (31%) BM samples examined were positive for CK-expressing cells, in agreement with previous studies [2,3].
Gene_expression (expressing) of CK
11) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.49 Pain Relevance 0
Ten out of the 32 (31%) BM samples examined were positive for CK-expressing cells, in agreement with previous studies [2,3].
Gene_expression (-) of CK
12) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.49 Pain Relevance 0
The fact that subsets of disseminated cells can express EpCAM and CK markers independently, and that carcinoma cells with low antigen expression may be missed by both methods, may account for the difficulty in reconciling IC and IM data.


Gene_expression (express) of CK associated with carcinoma
13) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.72 Pain Relevance 0
Major CK alterations observed in breast cancer could be reflected by the reduced or increased expression of individual CK, and by partial loss of the normal regulation of CK expression [45].
Gene_expression (expression) of CK associated with breast cancer
14) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.86 Pain Relevance 0
Modulation of CK expression along with tumor progression has also been reported [42-44].
Gene_expression (expression) of CK associated with cancer
15) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 1.01 Pain Relevance 0
Major CK alterations observed in breast cancer could be reflected by the reduced or increased expression of individual CK, and by partial loss of the normal regulation of CK expression [45].
Gene_expression (expression) of CK associated with breast cancer
16) Confidence 0.14 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC549166 Disease Relevance 0.74 Pain Relevance 0
Aberrant expression of cytokeratins (CK) is known to occasionally occur in malignant lymphomas.
Gene_expression (expression) of CK associated with lymphatic system cancer
17) Confidence 0.08 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.36 Pain Relevance 0.03
Aberrant CK expression can be encountered in a small subset of otherwise characteristic B and T cell lymphomas, but not in acute leukemias [57].


Gene_expression (expression) of CK in T cell associated with t-cell lymphoma and leukemia
18) Confidence 0.08 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.46 Pain Relevance 0
Using tissue microarray technology, 1,059 lymphoma and acute leukemia cases, covering the most common disease entities, were tested for aberrant CK expression using CK22.
Gene_expression (expression) of CK in covering associated with leukemia, lymphatic system cancer and disease
19) Confidence 0.08 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.49 Pain Relevance 0
All CK22-positive cases, except for one MCL, expressed the specific simple epithelial CK8 but not the basal/stratified epithelial CK5/6.
Gene_expression (expressed) of CK22 associated with mantle-cell lymphoma
20) Confidence 0.06 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.59 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox