INT4616

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 8
Speculated 4
Reported most in Abstract
Documents 40
Total Number 44
Disease Relevance 6.09
Pain Relevance 15.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 11
blood 5
liver 5
plasma 2
heart 1
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 75 100.00 Very High Very High Very High
local anesthetic 33 100.00 Very High Very High Very High
antidepressant 18 100.00 Very High Very High Very High
Catecholamine 14 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
tricyclic antidepressant 4 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
anesthesia 8 99.92 Very High Very High Very High
Dopamine 30 99.84 Very High Very High Very High
Glutamate 8 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 7 100.00 Very High Very High Very High
Shock 3 100.00 Very High Very High Very High
Toxicity 4 99.54 Very High Very High Very High
Nociception 5 99.40 Very High Very High Very High
Hypothermia 4 98.56 Very High Very High Very High
INFLAMMATION 6 98.38 Very High Very High Very High
Migraine Disorders 4 97.36 Very High Very High Very High
Hypertension 7 97.04 Very High Very High Very High
Arrhythmia Under Development 2 97.00 Very High Very High Very High
Ganglion Cysts 3 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of predictable or unpredictable shocks on ambulation, pain sensitivity, plasma catecholamines and heart and brain monoamine oxidase (MAO) inhibitory activity were investigated in rats.
Regulation (effects) of MAO in plasma associated with pain, catecholamine, shock and monoamine
1) Confidence 0.62 Published 1994 Journal Behav. Brain Res. Section Abstract Doc Link 8031501 Disease Relevance 0.28 Pain Relevance 0.32
The effects of various local anesthetics on rat brain and liver monoamine oxidase (MAO) and their antihemolytic and local anesthetic effects were studied.
Regulation (effects) of monoamine oxidase in liver associated with monoamine and local anesthetic
2) Confidence 0.62 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6285048 Disease Relevance 0 Pain Relevance 0.63
The effects of various local anesthetics on rat brain and liver monoamine oxidase (MAO) and their antihemolytic and local anesthetic effects were studied.
Regulation (effects) of MAO in liver associated with monoamine and local anesthetic
3) Confidence 0.62 Published 1982 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 6285048 Disease Relevance 0 Pain Relevance 0.63
AIM: To study the regulation of monoamine oxidase-B (MAO-B) activity and imidazoline receptors (I-R) during long term treatment of morphine.
Regulation (regulation) of MAO-B associated with morphine and monoamine
4) Confidence 0.62 Published 2001 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11749830 Disease Relevance 0 Pain Relevance 0.22
Although agmatine itself did not affect MAO-B activity, co-administration of agmatine with morphine could reverse the effect of morphine on MAO-B activity.
Neg (not) Regulation (affect) of MAO-B
5) Confidence 0.62 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749830 Disease Relevance 0 Pain Relevance 0
RESULTS: Idazoxan and morphine inhibited whole brain homogenate MAO-B activity in a dose-dependent manner, while agmatine, an endogenous imidazoline ligand, didn't affect the activity of MAO-B, and it had no effect on the inhibition of MAO-B activity by idazoxan or morphine.
Regulation (affect) of MAO-B in brain
6) Confidence 0.62 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749830 Disease Relevance 0 Pain Relevance 0
The effect of the local anesthetics, tetracaine and bupivacaine, on monoamine oxidase (MAO) activity of rat brain and on the major steps of catecholamine and 5-hydroxytryptamine (5-HT) turnover was examined.
Spec (examined) Regulation (effect) of monoamine oxidase in brain associated with catecholamine, monoamine and local anesthetic
7) Confidence 0.61 Published 1987 Journal Pain Section Abstract Doc Link 3614961 Disease Relevance 0 Pain Relevance 0.36
The effect of the local anesthetics, tetracaine and bupivacaine, on monoamine oxidase (MAO) activity of rat brain and on the major steps of catecholamine and 5-hydroxytryptamine (5-HT) turnover was examined.
Spec (examined) Regulation (effect) of MAO in brain associated with catecholamine, monoamine and local anesthetic
8) Confidence 0.61 Published 1987 Journal Pain Section Abstract Doc Link 3614961 Disease Relevance 0 Pain Relevance 0.36
Further examination of the protective action of flupirtine and retigabine against L-glutamate toxicity showed that it had no influence on monoamine oxidase (monoamine: oxygen oxidoreductase (deaminating), EC 1.4.3.4., MAO) activity.
Neg (no) Regulation (influence) of monoamine oxidase associated with toxicity, glutamate and monoamine
9) Confidence 0.61 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10988329 Disease Relevance 0.88 Pain Relevance 0.54
The effects of four monoamine oxidase (MAO) inhibitors on the blood pressure of conscious normotensive and DOC-salt hypertensive rats were measured.
Regulation (effects) of monoamine oxidase in blood associated with hypertension and monoamine
10) Confidence 0.45 Published 1985 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3839173 Disease Relevance 0.26 Pain Relevance 0.12
The effects of these MAO inhibitors on blood pressure responses to serotonin, tyramine and beta-phenylethylamine were determined in conscious normotensive rats.
Regulation (effects) of MAO in blood associated with serotonin
11) Confidence 0.45 Published 1985 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3839173 Disease Relevance 0.33 Pain Relevance 0.23
The effects of four monoamine oxidase (MAO) inhibitors on the blood pressure of conscious normotensive and DOC-salt hypertensive rats were measured.
Regulation (effects) of MAO in blood associated with hypertension and monoamine
12) Confidence 0.45 Published 1985 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 3839173 Disease Relevance 0.26 Pain Relevance 0.12
Possible mechanisms for the release-enhancing effect of the MAO-B inhibitors include elevation in levels of endogenous beta-phenylethylamine, or an inhibition of DA reuptake, which develops only on chronic administration, because both deprenyl and TVP-1012 have only very weak effects on amine uptake in acute experiments.
Regulation (effect) of MAO-B associated with dopamine
13) Confidence 0.45 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8858937 Disease Relevance 0 Pain Relevance 0.36
Effect of selective monoamine oxidase inhibitors on the morphine-induced hypothermia in restrained rats.
Regulation (Effect) of monoamine oxidase associated with hypothermia, narcan, morphine and monoamine
14) Confidence 0.45 Published 1987 Journal Gen. Pharmacol. Section Title Doc Link 3106135 Disease Relevance 0.27 Pain Relevance 0.73
The effects of monoamine oxidase inhibition (which decreases the amount of 5-hydroxyindoleacetic acid), as well as that of probenecid (which increases 5-hydroxyindoleacetic acid), suggests that 5-hydroxyindoleacetic acid rather than serotonin is measured.
Regulation (effects) of monoamine oxidase associated with serotonin and monoamine
15) Confidence 0.45 Published 1984 Journal Neuroscience Section Abstract Doc Link 6200799 Disease Relevance 0 Pain Relevance 0.21
The effects of both enantiomers of MDMA were examined on MAO-A and monoamine oxidase-B (MAO-B) activity in rat brain homogenates.
Regulation (effects) of MAO in brain associated with monoamine
16) Confidence 0.45 Published 1994 Journal Neuropsychopharmacology Section Abstract Doc Link 7945733 Disease Relevance 0 Pain Relevance 0.35
The monoamine oxidase (MAO) inhibitor, pargyline (10-100 microM), did not significantly affect 5-HT-induced contraction.
Neg (not) Regulation (affect) of MAO associated with monoamine
17) Confidence 0.45 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1358631 Disease Relevance 0 Pain Relevance 0.49
The monoamine oxidase (MAO) inhibitor, pargyline (10-100 microM), did not significantly affect 5-HT-induced contraction.
Neg (not) Regulation (affect) of monoamine oxidase associated with monoamine
18) Confidence 0.45 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1358631 Disease Relevance 0 Pain Relevance 0.50
The effect of various monoamine oxidase (MAO) inhibitors on the response of blood pressure of rats and cats to tyramine.
Regulation (effect) of monoamine oxidase in blood associated with anesthesia and monoamine
19) Confidence 0.45 Published 1990 Journal Acta Physiol Hung Section Title Doc Link 2127505 Disease Relevance 0 Pain Relevance 0.15
The effect of various monoamine oxidase (MAO) inhibitors on the response of blood pressure of rats and cats to tyramine.
Regulation (effect) of MAO in blood associated with anesthesia and monoamine
20) Confidence 0.45 Published 1990 Journal Acta Physiol Hung Section Title Doc Link 2127505 Disease Relevance 0 Pain Relevance 0.15

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