INT46173

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Context Info
Confidence 0.61
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.54
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
A549 1
trigeminal nerve 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 4 97.76 Very High Very High Very High
fifth nerve 1 96.20 Very High Very High Very High
chemokine 5 94.88 High High
Pain 3 93.44 High High
Facet joint 1 83.68 Quite High
cytokine 5 47.12 Quite Low
Inflammation 13 22.44 Low Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Flavivirus Infection 160 100.00 Very High Very High Very High
Headache 6 97.76 Very High Very High Very High
Dengue 208 96.24 Very High Very High Very High
Pain 3 93.44 High High
Increased Venous Pressure Under Development 3 91.96 High High
Infection 76 89.20 High High
Hypertrophy 1 86.56 High High
Pneumonia 6 22.44 Low Low
Hypersensitivity 17 21.52 Low Low
Leukemia 1 14.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In one case the symptoms were confined to the ear, another was associated with sensory impairment in the distribution of the C2 and C3 segments, while the 3rd patient experienced discomfort in the area of the 1st division of the trigeminal nerve on the same side.
Transcription (distribution) of C3 in trigeminal nerve associated with fifth nerve
1) Confidence 0.61 Published 1994 Journal Clin Exp Neurol Section Abstract Doc Link 7586661 Disease Relevance 0.27 Pain Relevance 0.18
The elevated levels of C3a and C5a that we observed in DHF patients are consistent with their decreased levels of C3 and further confirm the association of high complement activity with DHF.


Transcription (levels) of C3 associated with flavivirus infection
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.49 Pain Relevance 0
In support of the microarray findings, IL-4 is known to increase C3 mRNA levels and subsequent protein production in A549 cells, a pulmonary epithelial cell line [37].
Transcription (levels) of C3 in A549
3) Confidence 0.44 Published 2002 Journal Genome Biol Section Body Doc Link PMC115222 Disease Relevance 0 Pain Relevance 0.05
The elevated levels of C3a and C5a that we observed in DHF patients are consistent with their decreased levels of C3 and further confirm the association of high complement activity with DHF.


Transcription (levels) of C3a associated with flavivirus infection
4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 1.54 Pain Relevance 0
In 54 patients with migraine and 70 persons comprising the control group, the total complement level (CH50) was evaluated together with its C3 and C4 fraction level and the level of IgG, IgA and IgM immunoglobulins.
Transcription (level) of C3 associated with migraine
5) Confidence 0.18 Published 1983 Journal Cephalalgia Section Abstract Doc Link 6871986 Disease Relevance 0.25 Pain Relevance 0.30

General Comments

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