INT46205

Context Info Confidence 0.37 First Reported 1983 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.41 Pain Relevance 0.37

transport (Slc10a2) nucleus (Slc10a2)

Anatomy Link Frequency brush 1 heart 1 Slc10a2 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 30 99.60 Bile 53 98.84 Catecholamine 1 79.84 opiate 1 62.96 antagonist 1 62.40 sodium channel 6 5.00 anesthesia 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Obesity 13 100.00 Cystic Fibrosis 30 99.60 Congenital Anomalies 1 75.36 Targeted Disruption 9 75.00 Hypothermia 1 70.48 Liver Disease 2 5.00 Disease 2 5.00 Sprains And Strains 1 5.00 Dislocations 1 5.00 Lower Respiratory Tract Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These findings indicate that bile acid malabsorption in cystic fibrosis is not caused by a decrease in IBAT activity at the brush border.

Negative_regulation (decrease) of IBAT in brush associated with fibrosis, bile and cystic fibrosis

1) Confidence 0.37 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.23 Pain Relevance 0.24

The results from studies utilizing radiolabeled NE or inhibition of NE biosynthesis with alpha-methyl-p-tyrosine to measure NE turnover demonstrated reductions in SNS activity of 33-56% in heart and of 45-73% in IBAT in ob/ob mice at ambient temperature (22 degrees C) compared with measurements in lean controls.

Negative_regulation (reductions) of IBAT in heart associated with obesity

2) Confidence 0.36 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 1.18 Pain Relevance 0.13

General Comments

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