INT46206

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.57
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn10a) plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
neurons 2
SNS 2
plasma 1
thyroid 1
Scn10a (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 3 100.00 Very High Very High Very High
sodium channel 1 100.00 Very High Very High Very High
electroacupuncture 26 99.68 Very High Very High Very High
agonist 15 99.64 Very High Very High Very High
Inflammation 9 98.44 Very High Very High Very High
Catecholamine 1 93.44 High High
Hippocampus 5 83.32 Quite High
cerebral cortex 5 82.80 Quite High
Antinociceptive 1 76.44 Quite High
withdrawal 1 73.04 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 206 100.00 Very High Very High Very High
Nociception 8 99.08 Very High Very High Very High
INFLAMMATION 7 98.44 Very High Very High Very High
Obesity 13 96.40 Very High Very High Very High
Stress 75 95.60 Very High Very High Very High
Congenital Anomalies 6 88.96 High High
Syndrome 136 84.32 Quite High
Cancer 123 82.28 Quite High
Urological Neuroanatomy 2 79.20 Quite High
Sprains And Strains 45 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the sympathetic nervous system (SNS) is subject to feedback regulation, a peripheral impairment in thermogenesis should be associated with a compensatory increase in SNS activity.
Positive_regulation (increase) of SNS in SNS
1) Confidence 0.60 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 0.71 Pain Relevance 0.05
As controls we used riboprobes generated against TrkA, the neuropeptide CGRP and the sodium channel Scn10a, all known markers of nociceptive neurons.
Positive_regulation (generated) of Scn10a in neurons associated with nociception, sodium channel and neuropeptide
2) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.18 Pain Relevance 0.13
APP mRNA did not decay over 120 min regardless of mGluR activation in WT and KO SNs (Figure S2).
Positive_regulation (activation) of SNs associated with targeted disruption
3) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.57 Pain Relevance 0.08
Protease inhibitors increased steady-state levels of APP in WT SNs to those seen in KO SNs (unpublished data).
Positive_regulation (increased) of SNs associated with targeted disruption
4) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.75 Pain Relevance 0
The present study was designed to evaluate the differential effect of low (1Hz, LF EA) versus high (120Hz, HF EA) frequency EA stimulation on SNS activation and ultimately on carrageenan-induced inflammation.
Positive_regulation (activation) of SNS in SNS associated with inflammation and electroacupuncture
5) Confidence 0.24 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18355649 Disease Relevance 0.68 Pain Relevance 1.03
These data suggest that APP mRNA is translationally repressed by FMRP in unstimulated WT SNs. mGluR activation rapidly derepresses APP synthesis as shown for FMRP and PSD-95 [21,22].
Positive_regulation (unstimulated) of SNs
6) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.73 Pain Relevance 0
We now show that after stimulation with the mGluR agonist DHPG, APP levels increased significantly in wild-type (WT) but not synaptoneurosomes (SNs) or cultured neurons from knockout (KO) animals.
Positive_regulation (increased) of SNs in neurons associated with targeted disruption and agonist
7) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.35 Pain Relevance 0.08
After 1 hr, APP remained elevated in stimulated SNs over the control, but the difference was less (1.6-fold) than at 15 min, suggesting more persistent translation in the unstimulated controls, slowing of new synthesis after stimulation, and/or compensatory protein turnover in the DHPG-treated samples (Figure 3A and 3B).
Positive_regulation (stimulated) of SNs
8) Confidence 0.19 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.47 Pain Relevance 0
This stimulatory effect could be mediated by the brief action of the SNS (via norepinephrine), of beta-endorphin, T3, or T4 or sustained action of ACTH and IL-2 (Table 2).
Positive_regulation (action) of SNS
9) Confidence 0.10 Published 2007 Journal Infect Agent Cancer Section Body Doc Link PMC2211456 Disease Relevance 0.39 Pain Relevance 0
This effect could be explained by transient activation of the sympathetic nervous system (SNS) [15,16], the hypothalamic-pituitary-adrenal (HPA) axis [17,18] as well as the hypothalamic-pituitary-thyroid (HPT) axis [19,20] resulting in a brief action of norepinephrine, adrenocorticotropic hormone (ACTH), beta-endorphin, and thyroid hormones (triiodothyronine (T3) and thyroxine (T4)) on cytotoxic T lymphocytes (CTLs) and NK cells.
Positive_regulation (activation) of SNS in thyroid
10) Confidence 0.10 Published 2007 Journal Infect Agent Cancer Section Body Doc Link PMC2211456 Disease Relevance 0.55 Pain Relevance 0
The immediate/transient effects reported in mice and humans include: brief activation of the SNS [15,16], of the HPA axis [17,18] and of the HPT axis [19,20] with a significant increase in the metabolic rate [29] and in plasma levels of norepinephrine [15,16], ACTH [30,31], corticosterone [7], beta-endorphin [18,32], T3 [19,20], T4 [20], as well as a modest or undetectable increase in the plasma levels of interleukin-6 (IL-6) [12,13] and cortisol [33,34] (Table 1).
Positive_regulation (activation) of SNS in plasma
11) Confidence 0.09 Published 2007 Journal Infect Agent Cancer Section Body Doc Link PMC2211456 Disease Relevance 1.19 Pain Relevance 0

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