INT46207

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Context Info
Confidence 0.69
First Reported 1983
Last Reported 2001
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 3.80
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc10a2) nucleus (Slc10a2)
Anatomy Link Frequency
ileum 1
IBAT 1
brush 1
Slc10a2 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 210 99.56 Very High Very High Very High
Bile 371 98.86 Very High Very High Very High
sodium channel 42 95.96 Very High Very High Very High
opiate 1 76.72 Quite High
antagonist 1 76.16 Quite High
Catecholamine 1 71.36 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 13 100.00 Very High Very High Very High
Cystic Fibrosis 210 99.84 Very High Very High Very High
Targeted Disruption 63 99.38 Very High Very High Very High
Hypothermia 1 92.12 High High
Lower Respiratory Tract Infection 7 70.44 Quite High
Congenital Anomalies 1 66.88 Quite High
Liver Disease 14 47.56 Quite Low
Disease 14 5.00 Very Low Very Low Very Low
Sprains And Strains 7 5.00 Very Low Very Low Very Low
Dislocations 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This increase in IBAT function was paralleled by increases in IBAT protein concentrations.
Positive_regulation (increases) of IBAT
1) Confidence 0.69 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.64 Pain Relevance 0.61
This increase in IBAT function was paralleled by increases in IBAT protein concentrations.
Positive_regulation (increase) of IBAT
2) Confidence 0.60 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.64 Pain Relevance 0.61
Increased bile acid transport in cftr (-/-) mice is associated with an increase in the abundance of IBAT protein in the brush border membrane.
Positive_regulation (increase) of IBAT in brush associated with bile
3) Confidence 0.50 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.07 Pain Relevance 0.27
An alternative mechanism for the upregulation of IBAT in cystic fibrosis is that CFTR acts as a negative regulator of IBAT, as it does for the epithelial sodium channel [36].
Positive_regulation (upregulation) of IBAT associated with fibrosis, cystic fibrosis and sodium channel
4) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.30 Pain Relevance 0.56
In the ileum, IBAT protein densities and taurocholate uptake rates are elevated in cftr (-/-) mice > cftr (+/-) > wild-type mice.
Positive_regulation (elevated) of IBAT in ileum
5) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.23 Pain Relevance 0.28
IBAT protein was comparably increased.
Positive_regulation (increased) of IBAT
6) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Abstract Doc Link PMC59644 Disease Relevance 0.28 Pain Relevance 0.33
Our results suggest that knockout of CFTR leads to an analogous increase in expression and function of IBAT.
Positive_regulation (increase) of IBAT associated with targeted disruption
7) Confidence 0.40 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0.39 Pain Relevance 0.37
During cold exposure (4 degrees C) NE turnover increased in heart and IBAT to a similar extent in both ob/ob and lean mice, but NE turnover rates in heart, and probably in IBAT as well, remained lower in the obese mice than in the lean despite the gradual development of hypothermia in the ob/ob mice during this period.
Positive_regulation (increased) of IBAT in IBAT associated with hypothermia and obesity
8) Confidence 0.39 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 1.25 Pain Relevance 0.15

General Comments

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