INT46208

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 7.16
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn10a) plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
SNS 2
neurons 1
heart 1
Scn10a (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 33 99.54 Very High Very High Very High
antagonist 4 99.52 Very High Very High Very High
opiate 4 99.30 Very High Very High Very High
sodium channel 13 98.34 Very High Very High Very High
Pain 340 98.08 Very High Very High Very High
dorsal root ganglion 54 97.96 Very High Very High Very High
Eae 78 92.52 High High
tetrodotoxin 4 91.68 High High
Brush evoked pain 63 89.40 High High
qutenza 11 87.76 High High
Disease Link Frequency Relevance Heat
Obesity 39 99.36 Very High Very High Very High
Sprains And Strains 395 98.96 Very High Very High Very High
Pain 362 98.08 Very High Very High Very High
Ganglion Cysts 129 97.96 Very High Very High Very High
Hypothermia 3 95.04 Very High Very High Very High
Neuropathic Pain 192 89.40 High High
Stress 6 81.80 Quite High
Congenital Anomalies 3 75.36 Quite High
Inflammatory Pain 2 75.12 Quite High
Nociception 18 67.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that diminished SNS activity in ob/ob mice may be an additional factor contributing to the defective thermogenesis characteristic of these animals.
Negative_regulation (diminished) of SNS in SNS associated with obesity
1) Confidence 0.58 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 1.07 Pain Relevance 0.17
Administration of naltrexone, a long-acting opiate antagonist, failed to reverse the suppression of SNS activity observed in the ob/ob mice.
Negative_regulation (suppression) of SNS in SNS associated with antagonist, obesity and opiate
2) Confidence 0.51 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 1.15 Pain Relevance 0.18
The degree of down-regulation of Scn10a was not identical across strains, but the across strains correlation was not significant for any of the three pain parameters considered.
Negative_regulation (regulation) of Scn10a associated with pain and sprains and strains
3) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.30 Pain Relevance 0.56
Axotomy induced marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 in all 5 strains with lesser and variable change observed for P2rx3 and Trpv1 (Fig. 1).
Negative_regulation (regulation) of Scn10a associated with sprains and strains
4) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.07 Pain Relevance 0.53
That is, all of the methods showed marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 with lesser and variable change in P2rx3 and Trpv1.
Negative_regulation (regulation) of Scn10a
5) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.60 Pain Relevance 0.28
The results from studies utilizing radiolabeled NE or inhibition of NE biosynthesis with alpha-methyl-p-tyrosine to measure NE turnover demonstrated reductions in SNS activity of 33-56% in heart and of 45-73% in IBAT in ob/ob mice at ambient temperature (22 degrees C) compared with measurements in lean controls.
Negative_regulation (reductions) of SNS in heart associated with obesity
6) Confidence 0.37 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6881329 Disease Relevance 1.10 Pain Relevance 0.13
For example, a
               mouse lacking SCN10A, the gene encoding the voltage-gated sodium
               channel NaV1.8, was recently reported to have almost complete
               insensitivity to cold pain [10]. 
Negative_regulation (lacking) of SCN10A associated with pain
7) Confidence 0.33 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.81 Pain Relevance 0.72
Expression of mRNAs for SNS and NaN voltage-dependent sodium channels in cultures of DRG neurons is restored by GDNF, whereas NGF is reported to rescue downregulation of SNS, not NaN (Fjell et al. 1999c).
Negative_regulation (downregulation) of SNS in neurons associated with nerve growth factor and sodium channel
8) Confidence 0.17 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.06 Pain Relevance 0.89

General Comments

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