INT46221

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Context Info
Confidence 0.53
First Reported 1983
Last Reported 2010
Negated 7
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 33.66
Pain Relevance 7.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CII 10
T-cell 10
B-cells 6
blood 4
lung 4
IgG (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 363 100.00 Very High Very High Very High
cytokine 220 100.00 Very High Very High Very High
Arthritis 532 99.98 Very High Very High Very High
rheumatoid arthritis 408 99.84 Very High Very High Very High
depression 4 99.36 Very High Very High Very High
Acupuncture 57 98.52 Very High Very High Very High
spinal inflammation 2 98.36 Very High Very High Very High
Osteoarthritis 5 97.40 Very High Very High Very High
diclofenac 24 94.80 High High
Spinal cord 68 90.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 376 100.00 Very High Very High Very High
Neuromyelitis Optica 215 100.00 Very High Very High Very High
Influenza Virus Infection 167 100.00 Very High Very High Very High
Togavirus Infection 140 100.00 Very High Very High Very High
Fever 9 100.00 Very High Very High Very High
Exanthema 2 100.00 Very High Very High Very High
Arthritis 626 99.98 Very High Very High Very High
Rheumatoid Arthritis 408 99.84 Very High Very High Very High
Immunization 268 99.76 Very High Very High Very High
Bullous Skin Disease 93 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S Le(x) expression on IgG was elevated above the reference range in all but one of the RA patients and this change was highly significant (P < 0.0006).
Positive_regulation (elevated) of Gene_expression (expression) of IgG associated with rheumatoid arthritis
1) Confidence 0.53 Published 1998 Journal Glycoconj. J. Section Abstract Doc Link 10372970 Disease Relevance 1.64 Pain Relevance 0.61
PTXF treatment was associated with an increase in IgG production, but a greater depression in IgM synthesis than burn injury alone.
Positive_regulation (increase) of Gene_expression (production) of IgG associated with depression, burns and injury
2) Confidence 0.41 Published 1997 Journal J Burn Care Rehabil Section Abstract Doc Link 9313117 Disease Relevance 1.87 Pain Relevance 0.17
Collectively, these data suggest that diclofenac: (i) induces a T-cell-dependent direct PLN reaction that; (ii) provides non-cognate help for IgG AFC production when co-injected with TNP-Ficoll, possibly through the formation of neo-antigens; and (iii) possesses intrinsic adjuvant activity that selectively induces IL-4 mediated production of IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (mediated) of Gene_expression (production) of IgG in T-cell associated with diclofenac
3) Confidence 0.39 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.23
Collectively, these data suggest that diclofenac: (i) induces a T-cell-dependent direct PLN reaction that; (ii) provides non-cognate help for IgG AFC production when co-injected with TNP-Ficoll, possibly through the formation of neo-antigens; and (iii) possesses intrinsic adjuvant activity that selectively induces IL-4 mediated production of IgG(1) and IgE against co-injected TNP-OVA.
Positive_regulation (induces) of Gene_expression (production) of IgG in T-cell associated with diclofenac
4) Confidence 0.39 Published 2002 Journal Toxicol. Lett. Section Abstract Doc Link 11992736 Disease Relevance 0 Pain Relevance 0.26
Additionally, increased levels of albumin and IgG have been found in the cerebrospinal fluid in ALS patients.
Positive_regulation (increased) of Gene_expression (levels) of IgG in cerebrospinal fluid
5) Confidence 0.35 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.16 Pain Relevance 0.17
Rubella IgM testing was not included in this analysis because the testing protocol for rubella IgM included only patients with negative rubella IgG results and symptoms of fever and rash, which increases the likelihood of the patient being a clinical rubella case.
Positive_regulation (increases) of Neg (negative) Gene_expression (results) of IgG associated with exanthema, togavirus infection and fever
6) Confidence 0.34 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2844547 Disease Relevance 1.41 Pain Relevance 0
Sera with values of < 10 IU/mL were defined as negative for rubella IgG antibodies and those with values ?
Positive_regulation (negative) of Gene_expression (antibodies) of IgG associated with togavirus infection
7) Confidence 0.34 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2844547 Disease Relevance 1.07 Pain Relevance 0
Evidence for the pathogenicity of these circulating AAb is provided by the observations that (1) the activity of pemphigus correlates with AAb titers, (2) newborns of mothers with active pemphigus temporarily exhibit blisters due to the transplacentar transfer of maternal AAb and (3) pemphigus-like lesions are induced in neonatal mice by transfer of IgG from PV patients.
Positive_regulation (transfer) of Gene_expression (transfer) of IgG associated with blister and bullous skin disease
8) Confidence 0.31 Published 2001 Journal Skin Pharmacol. Appl. Skin Physiol. Section Abstract Doc Link 11598441 Disease Relevance 2.44 Pain Relevance 0.08
Maternal transfer of IgG endows offspring with short-term protective immunity [5-7].
Positive_regulation (transfer) of Gene_expression (transfer) of IgG
9) Confidence 0.30 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.25 Pain Relevance 0
In the present study, CII immunization remarkably increased collagen II antibody, IgG and IgM levels in mice serum, while EA at ST36 significantly reduced these levels in comparison with the control group or the NR group.
Positive_regulation (increased) of Gene_expression (antibody) of IgG in CII associated with immunization and acupuncture
10) Confidence 0.24 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1810363 Disease Relevance 1.91 Pain Relevance 0.91
In contrast, when combining the RTX-treated patients into one group, no subclass distinction in IgG production could be detected.
Neg (no) Positive_regulation (distinction) of Gene_expression (production) of IgG
11) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.48 Pain Relevance 0
Given that antibodies are extraordinarily powerful at neutralizing virus, preventing further infection, clearing antigen and even dampening inflammation via FcR ligation, the accelerated IgG and IgA responses in the lung most likely contribute, at least partially, to the enhanced viral clearance in PCN-treated mice.
Positive_regulation (accelerated) of Gene_expression (responses) of IgG in lung associated with inflammation and infection
12) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743193 Disease Relevance 0.77 Pain Relevance 0.12
We observed a substantial increase in influenza virus-specific IgG levels 14 days after immunization in the sera of immunized mice as compared to the naïve group (p<0.001) (Figure 3A).
Positive_regulation (increase) of Gene_expression (levels) of IgG associated with influenza virus infection and immunization
13) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.79 Pain Relevance 0
IgG not bound to the FcRn is transferred to lysosomes for degradation [45].
Positive_regulation (transferred) of Gene_expression (transferred) of IgG
14) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.93 Pain Relevance 0.15
IgG antibodies are necessary but not sufficient for G6PI-induced arthritis in normal mice
Neg (not) Positive_regulation (necessary) of Gene_expression (antibodies) of IgG associated with arthritis
15) Confidence 0.19 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.48 Pain Relevance 0.52
RII develop elevated IgG anti-CII levels and enhanced disease.
Positive_regulation (elevated) of Gene_expression (levels) of IgG in CII associated with disease
16) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 1.37 Pain Relevance 0.47
Further characterization of Ebola glycoprotein-specific Ig isotypes revealed that the PEGylated vector could possibly stimulate production of IgG in the presence or absence of pre-existing immunity with respect to levels found in animals given the unmodified vector (Figure 6C).
Positive_regulation (stimulate) of Gene_expression (production) of IgG associated with ebola virus infection
17) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2569416 Disease Relevance 0.26 Pain Relevance 0
contributed to B-cell activation and increased immunoglobulin production (IgM and IgG) of blood B cells [49].
Positive_regulation (increased) of Gene_expression (production) of IgG in B-cell
18) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08
Hormonal status does not affect arthritis-induced increased levels of pro-inflammatory cytokines, IgG and CII antibodies
Positive_regulation (increased) of Gene_expression (levels) of IgG in CII associated with inflammation, cytokine and arthritis
19) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.33 Pain Relevance 0.45
Hormonal status does not affect arthritis-induced increased levels of pro-inflammatory cytokines, IgG and CII antibodies
Positive_regulation (induced) of Gene_expression (levels) of IgG in CII associated with inflammation, cytokine and arthritis
20) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.33 Pain Relevance 0.45

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