INT46271

Context Info Confidence 0.29 First Reported 1982 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 0.11

cytosol (MAPKAP1) cytoplasmic membrane-bounded vesicle (MAPKAP1) plasma membrane (MAPKAP1) nucleus (MAPKAP1) biological_process (MAPKAP1) response to stress (MAPKAP1)

MAPKAP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 1 80.08 tetrodotoxin 1 68.40 Angina 2 40.88 agonist 13 5.00 imagery 2 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Hypertension 4 5.00 Targeted Disruption 4 5.00 Thrombosis 3 5.00 Stress 3 5.00 Atherosclerosis 3 5.00 Disease 2 5.00 Cv General 3 Under Development 2 5.00 Myocardial Infarction 2 5.00 Coronary Artery Disease 1 5.00 Muscular Spasm 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Rolipram also potentiated responses to SIN-1 and sodium nitroprusside.

Regulation (responses) of SIN-1

1) Confidence 0.29 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7952568 Disease Relevance 0 Pain Relevance 0.07

The IC50-values of SIN-1, which is the pharmacologically active biotransformation product of molsidomine, were about 1 mumol/l in the experimental models used.

Regulation (values) of SIN-1

2) Confidence 0.20 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 6896278 Disease Relevance 0 Pain Relevance 0.04

We have previously established that while both prostacyclin analogues, such as Cicaprost, and NO-donors, such as SIN-1, were indeed capable of cross-desensitizing or impairing Gq/PLC?

Regulation (capable) of SIN-1

3) Confidence 0.07 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

General Comments

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