INT46276

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2003
Negated 4
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.86
Pain Relevance 6.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
hypothalamus 4
dorsal 3
sciatic nerve 2
acinar cells 2
ventral 1
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 90 100.00 Very High Very High Very High
Endogenous opioid 8 100.00 Very High Very High Very High
Neurotransmitter 3 100.00 Very High Very High Very High
narcan 1 100.00 Very High Very High Very High
Enkephalin 9 99.92 Very High Very High Very High
opiate 17 99.78 Very High Very High Very High
substance P 8 99.32 Very High Very High Very High
amygdala 7 99.24 Very High Very High Very High
Neuropeptide 7 98.96 Very High Very High Very High
intrathecal 6 97.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 6 98.84 Very High Very High Very High
Urological Neuroanatomy 2 96.56 Very High Very High Very High
Lordosis 3 93.40 High High
Ganglion Cysts 2 82.52 Quite High
Reprotox - General 1 2 50.36 Quite High
Diarrhoea 2 49.64 Quite Low
Vomiting 2 49.24 Quite Low
Acid Reflux 2 48.92 Quite Low
Abdominal Pain 2 48.12 Quite Low
Disease 1 28.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that evodiamine inhibits both gastric emptying and gastrointestinal transit in male rats via a mechanism involving CCK release and CCK(1) receptor activation.
Regulation (involving) of Positive_regulation (activation) of CCK associated with cholecystokinin
1) Confidence 0.45 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12464363 Disease Relevance 0.05 Pain Relevance 0.39
These results suggest that evodiamine inhibits both gastric emptying and gastrointestinal transit in male rats via a mechanism involving CCK release and CCK(1) receptor activation.
Regulation (involving) of Positive_regulation (activation) of CCK associated with cholecystokinin
2) Confidence 0.45 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12464363 Disease Relevance 0.05 Pain Relevance 0.39
We have recently demonstrated that the upregulation of CCK mRNA is not accompanied by an increased potassium-evoked release CCK-like immunoreactivity (CCK-LI) 2-4 weeks after a complete transection of the sciatic nerve.
Neg (not) Regulation (accompanied) of Positive_regulation (upregulation) of CCK in sciatic nerve associated with sciatic nerve and cholecystokinin
3) Confidence 0.44 Published 2001 Journal Neuroreport Section Abstract Doc Link 11201090 Disease Relevance 0 Pain Relevance 0.67
To determine the effect of endogenous opioid input on estrogen-induced cholecystokinin, enkephalin and substance P expression, in situ hybridization histochemistry was used to examine estrogen-induced messenger RNA levels of these neuropeptides in specific nuclei of the limbic system and hypothalamus in the presence of opiate receptor antagonists.
Spec (determine) Regulation (effect) of Spec (determine) Positive_regulation (estrogen-induced) of cholecystokinin in hypothalamus associated with antagonist, neuropeptide, endogenous opioid, opiate, enkephalin, limbic system, cholecystokinin and substance p
4) Confidence 0.37 Published 1997 Journal Neuroscience Section Abstract Doc Link 9284350 Disease Relevance 0.10 Pain Relevance 1.48
Opiate receptors modulate estrogen-induced cholecystokinin and tachykinin but not enkephalin messenger RNA levels in the limbic system and hypothalamus.
Neg (not) Regulation (modulate) of Neg (not) Positive_regulation (estrogen-induced) of cholecystokinin in hypothalamus associated with enkephalin, opiate, limbic system and cholecystokinin
5) Confidence 0.37 Published 1997 Journal Neuroscience Section Title Doc Link 9284350 Disease Relevance 0.07 Pain Relevance 1.40
The estrogenic induction of CCK mRNA appears to be dependent on estrogen sensitive pathways of neurotransmission, or components of second messenger pathways which regulate CCK mRNA expression in the adult limbic-hypothalamic lordosis regulating circuit, which are not functional before PND 18-25.
Regulation (dependent) of Positive_regulation (induction) of CCK mRNA associated with lordosis and cholecystokinin
6) Confidence 0.27 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9482232 Disease Relevance 0.15 Pain Relevance 0.44
Intrathecal colchicine (0.5 mg)produced a significant increase in the levels of VIP in the dorsal and ventral horn but had no effect on the levels of CCK.
Neg (no) Regulation (effect) of Neg (no) Positive_regulation (effect) of CCK in dorsal associated with cholecystokinin and intrathecal
7) Confidence 0.27 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.08 Pain Relevance 0.71
Role of different neurotransmitter systems in the cholecystokinin octapeptide-induced anxiogenic response in rats.
Regulation (Role) of Positive_regulation (induced) of cholecystokinin associated with neurotransmitter, narcan and cholecystokinin
8) Confidence 0.27 Published 1997 Journal Neuropeptides Section Title Doc Link 9243526 Disease Relevance 0 Pain Relevance 0.45
Intrathecal colchicine (0.5 mg)produced a significant increase in the levels of VIP in the dorsal and ventral horn but had no effect on the levels of CCK.
Neg (no) Regulation (effect) of in ventral Neg (no) Positive_regulation (effect) of CCK in dorsal associated with cholecystokinin and intrathecal
9) Confidence 0.09 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.08 Pain Relevance 0.71
Ethanol could lead to the onset of pancreatitis in a number of ways; the most recently discovered is its effect on intrapancreatic digestive enzyme activation, by either sensitizing acinar cells to pathologic stimuli or stimulating the release of a secretagogue (cholecystokinin) from duodenal I cells.
Regulation (effect) of Positive_regulation (stimulating) of cholecystokinin in acinar cells associated with pancreatitis and cholecystokinin
10) Confidence 0.01 Published 2003 Journal Pancreas Section Abstract Doc Link 14576489 Disease Relevance 0.27 Pain Relevance 0.18

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