INT46277

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2007
Negated 3
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.35
Pain Relevance 4.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
dorsal 3
nerve 2
ventral 1
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 31 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Neurotransmitter 1 100.00 Very High Very High Very High
Glutamate 1 99.92 Very High Very High Very High
narcan 3 99.48 Very High Very High Very High
Opioid 4 99.18 Very High Very High Very High
gABA 1 98.88 Very High Very High Very High
substance P 2 98.64 Very High Very High Very High
Serotonin 1 98.00 Very High Very High Very High
intrathecal 6 97.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 2 96.32 Very High Very High Very High
Vomiting 3 95.12 Very High Very High Very High
Pain 3 94.64 High High
Ganglion Cysts 2 82.52 Quite High
INFLAMMATION 3 75.00 Quite High
Post-operative Nausea 1 70.88 Quite High
Diarrhoea 1 68.72 Quite High
Functional Bowel Disorder 1 67.04 Quite High
Sleep Disorders 1 60.00 Quite High
Rheumatoid Arthritis 1 58.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, naloxone (2 mg/kg; i.v.), did not induce any change in the extracellular level of CCK in either group.
Neg (not) Positive_regulation (induce) of Neg (not) Regulation (change) of CCK associated with narcan
1) Confidence 0.70 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 1.36
Intrathecal colchicine (0.5 mg)produced a significant increase in the levels of VIP in the dorsal and ventral horn but had no effect on the levels of CCK.
Neg (no) Positive_regulation (effect) of Neg (no) Regulation (effect) of CCK in dorsal associated with cholecystokinin and intrathecal
2) Confidence 0.47 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.08 Pain Relevance 0.71
The results suggest that CCK antagonism of opioid-induced disruption of maternal behavior occurs due to the action of CCK on both CCK1 and CCK2 receptor subtypes.
Positive_regulation (occurs) of Regulation (action) of CCK associated with opioid and cholecystokinin
3) Confidence 0.45 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10495012 Disease Relevance 0 Pain Relevance 0.68
Intrathecal colchicine (0.5 mg)produced a significant increase in the levels of VIP in the dorsal and ventral horn but had no effect on the levels of CCK.
Neg (no) Positive_regulation (effect) of in ventral Neg (no) Regulation (effect) of CCK in dorsal associated with cholecystokinin and intrathecal
4) Confidence 0.16 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.08 Pain Relevance 0.71
The preferential localization on nerve endings is consistent with a physiological role of 5-HT3 receptors in the control of neurotransmitter release such as dopamine, cholecystokinin, glutamate, acetylcholine, GABA, substance P, or serotonin itself. 5-HT3-receptor agonists cause unpleasant effects like nausea and anxiety, and no clinical use has been considered.
Positive_regulation (role) of Regulation (control) of cholecystokinin in nerve associated with dopamine, anxiety disorder, vomiting, neurotransmitter, glutamate, gaba, agonist, cholecystokinin, serotonin and substance p
5) Confidence 0.02 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17316606 Disease Relevance 1.19 Pain Relevance 0.86

General Comments

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