INT46281

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 5.54
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm1) nucleoplasm (Calm1) cytoskeleton (Calm1)
cell cycle (Calm1) cellular_component (Calm1) biological_process (Calm1)
Anatomy Link Frequency
knee 2
hip 1
Calm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
complementary and alternative medicine 776 100.00 Very High Very High Very High
narcan 7 99.90 Very High Very High Very High
Osteoarthritis 192 99.56 Very High Very High Very High
Multiple sclerosis 740 99.12 Very High Very High Very High
Desipramine 3 98.50 Very High Very High Very High
analgesia 2 95.20 Very High Very High Very High
anesthesia 2 94.64 High High
Enkephalin 6 94.00 High High
antagonist 2 90.72 High High
agonist 1 84.12 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 188 99.56 Very High Very High Very High
Chronic Disease 90 99.46 Very High Very High Very High
Demyelinating Disease 760 99.12 Very High Very High Very High
Stupor 2 97.60 Very High Very High Very High
Disease 232 97.56 Very High Very High Very High
Cleidocranial Dysplasia 12 94.28 High High
Arthropathy 8 83.76 Quite High
Phobia 2 80.00 Quite High
Knee Osteoarthritis 4 75.00 Quite High
Mental Disorders 4 68.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Broom (2009) finds that although patients experience positive impacts of CAM engagement, like increased feeling of control, power and individual autonomy within therapeutic processes, they also experience problematic notions of self-healing and hyper-positivity, involving restrictive notions of self-discipline.
CAM Binding (engagement) of associated with complementary and alternative medicine
1) Confidence 0.48 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.57 Pain Relevance 0.27
It was concluded that NX and CAM interact with the same OR when algolytic test was used, however different type of OR might be involved in hot plate and stretching assays and anesthesia potentiation, too.
CAM Spec (might) Binding (interact) of associated with anesthesia and narcan
2) Confidence 0.42 Published 1982 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 6897745 Disease Relevance 0.17 Pain Relevance 1.27
Significant number of Japanese people are middle class or above and this may explain in part the reason why financial status did not predict the usage of CAM.
CAM Neg (not) Binding (usage) of associated with complementary and alternative medicine
3) Confidence 0.33 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0 Pain Relevance 0.16
It is somewhat surprising that with a high prevalence of CAM usage and presumed acceptance of CAM therapies in Japan, reporting of CAM usage by individuals to their orthodox medical practitioners was low.
CAM Binding (usage) of associated with complementary and alternative medicine
4) Confidence 0.33 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0.21 Pain Relevance 0.49
Several potential risks related to patientsÂ’ choice and use of CAM have been described in the literature: for example, contamination and negative interactions between herbal products and pharmaceuticals (Bjelakovic, Nikolova, Gluud, Simonetti, & Gluud, 2007); refusal of important conventional treatment and delay of diagnosis (Malik & Gopalan, 2003); CAM as an economical burden (Utian, 2005); and problematic notions of self-healing and hyper-positivity (Broom, 2009).
CAM Neg (negative) Binding (interactions) of associated with complementary and alternative medicine
5) Confidence 0.32 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.39 Pain Relevance 0.39
Patient with MS in this study value both their alternative practitioners and the alternative treatments, but their main focus is on CAM as a system of treatment able to frame and mobilise their own efforts in coping with their living with MS.


CAM Binding (practitioners) of associated with complementary and alternative medicine and multiple sclerosis
6) Confidence 0.32 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.43 Pain Relevance 0.47
MS patients were chosen between patients diagnosed with different chronic diseases because they are frequent users of CAM and their chronic condition gives them longstanding, extensive treatment experience both from the conventional health care system and from their use of different CAM modalities and providers (Apel et al., 2006; Nayak et al., 2003; Olsen, 2009; Schwarz et al., 2008).
CAM Binding (users) of associated with complementary and alternative medicine, multiple sclerosis and chronic disease
7) Confidence 0.32 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 1.07 Pain Relevance 0.35
The objective of this study is to assess the genetic association of the -16C/T polymorphism in CALM1 with knee OA in a Chinese Han population.


CALM1 Binding (association) of in knee associated with osteoarthritis
8) Confidence 0.29 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2576056 Disease Relevance 0.72 Pain Relevance 0.29
Through a large-scale association study with subsequent functional researches, the Japanese group have demonstrated a convincing association between the CALM1 core promoter polymorphism and Japanese hip OA.
CALM1 Binding (association) of in hip associated with osteoarthritis
9) Confidence 0.29 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2576056 Disease Relevance 0.39 Pain Relevance 0.19
Using a convincing genome-wide association study, a Japanese group has recently demonstrated a genetic association between the CALM1 core promoter polymorphism (-16C/T transition SNP, rs12885713) and OA susceptibility.
CALM1 Binding (association) of associated with osteoarthritis
10) Confidence 0.29 Published 2008 Journal BMC Med Genet Section Abstract Doc Link PMC2576056 Disease Relevance 0.59 Pain Relevance 0.29
The present study did not find any significant association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee OA in the Chinese Han population.
CALM1 Neg (not) Binding (association) of in knee associated with osteoarthritis
11) Confidence 0.29 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2576056 Disease Relevance 1.00 Pain Relevance 0.36
Imipramine and desipramine in vitro do not affect the aminopeptidase M activity, but they reversibly inhibits the aminoeptidase MII.
aminoeptidase MII Binding (inhibits) of associated with desipramine
12) Confidence 0.05 Published 1997 Journal Life Sci. Section Abstract Doc Link 9395259 Disease Relevance 0 Pain Relevance 0.67

General Comments

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