INT46291

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.91
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
brain 2
Dbh (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 24 100.00 Very High Very High Very High
noradrenaline 18 98.28 Very High Very High Very High
Neurotransmitter 2 98.12 Very High Very High Very High
addiction 4 97.80 Very High Very High Very High
cocaine 8 97.44 Very High Very High Very High
withdrawal 1 95.56 Very High Very High Very High
Morphine 7 87.12 High High
antagonist 5 86.56 High High
opiate 1 77.04 Quite High
alcohol 1 74.80 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.88 Very High Very High Very High
Cocaine Dependence 1 97.44 Very High Very High Very High
Disease 3 84.52 Quite High
Drug Dependence 2 82.16 Quite High
Hair Disease 3 77.84 Quite High
Depression 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular interest is disulfiram, an inhibitor of the NE biosynthetic enzyme dopamine beta-hydroxylase, which has demonstrated promising efficacy in the treatment of cocaine dependence in preliminary clinical trials.
Negative_regulation (inhibitor) of dopamine beta-hydroxylase associated with addiction, dopamine and cocaine
1) Confidence 0.56 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17164822 Disease Relevance 0.25 Pain Relevance 0.71
To determine whether noradrenaline (NA) is an essential neurotransmitter for addictive and appetitive behaviors, we measured drug and food seeking in transgenic mice lacking dopamine beta-hydroxylase (Dbh), the enzyme responsible for synthesizing NA.
Negative_regulation (lacking) of Dbh associated with targeted disruption, dopamine, neurotransmitter and noradrenaline
2) Confidence 0.43 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16899413 Disease Relevance 0.10 Pain Relevance 0.60
To determine whether noradrenaline (NA) is an essential neurotransmitter for addictive and appetitive behaviors, we measured drug and food seeking in transgenic mice lacking dopamine beta-hydroxylase (Dbh), the enzyme responsible for synthesizing NA.
Negative_regulation (lacking) of dopamine beta-hydroxylase associated with targeted disruption, dopamine, neurotransmitter and noradrenaline
3) Confidence 0.43 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16899413 Disease Relevance 0.10 Pain Relevance 0.60
Noradrenaline concentrations are also reduced in brain tissue of Mo mice and this reduction is associated with a decrease in the vivo activity of the copper metalloenzyme, dopamine beta-monooxygenase (EC 1.14.17.1).
Negative_regulation (decrease) of beta-monooxygenase in brain associated with dopamine and noradrenaline
4) Confidence 0.24 Published 1980 Journal Ciba Found. Symp. Section Abstract Doc Link 6907087 Disease Relevance 0.16 Pain Relevance 0.34
Many tissues contain potent inhibitors of dopamine beta-monooxygenase activity, and assays of this enzyme have utilized cupric ions to inactivate these inhibitors.
Negative_regulation (inhibitors) of beta-monooxygenase associated with dopamine
5) Confidence 0.17 Published 1980 Journal Ciba Found. Symp. Section Abstract Doc Link 6907087 Disease Relevance 0.15 Pain Relevance 0.37
The elevated in vitro activities of dopamine beta-monooxygenase obtained for both Mo brain and adrenal tissue may therefore reflect either a reduced inactivation of these endogenous inhibitors in the intact animal or the activation in vitro of apoenzyme.
Negative_regulation (reduced) of beta-monooxygenase in brain associated with dopamine
6) Confidence 0.17 Published 1980 Journal Ciba Found. Symp. Section Abstract Doc Link 6907087 Disease Relevance 0.14 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox