INT46295

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Context Info
Confidence 0.39
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.34
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
leukocyte 3
band 1
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 99.14 Very High Very High Very High
cINOD 3 99.14 Very High Very High Very High
dexamethasone 1 93.04 High High
diclofenac 1 90.96 High High
cytokine 21 89.64 High High
Inflammation 55 87.76 High High
fibrosis 19 74.32 Quite High
Inflammatory response 11 57.88 Quite High
chemokine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 107 100.00 Very High Very High Very High
Conjunctivitis 49 99.80 Very High Very High Very High
Heart Rate Under Development 38 99.48 Very High Very High Very High
INFLAMMATION 67 99.02 Very High Very High Very High
Hypersensitivity 13 98.52 Very High Very High Very High
Conjunctiva Disease 37 95.12 Very High Very High Very High
Liver Disease 43 87.24 High High
Asthma 4 80.80 Quite High
Cirrhosis 45 74.80 Quite High
Apoptosis 55 69.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
20 non-steroidal anti-inflammatory drugs and other agents were evaluated for their effectiveness in directly inhibiting the proteolytic activity of human leukocyte elastase and cathepsin G.
Regulation (effectiveness) of Negative_regulation (inhibiting) of elastase in leukocyte associated with inflammation and cinod
1) Confidence 0.39 Published 1980 Journal Arzneimittelforschung Section Abstract Doc Link 6908533 Disease Relevance 0.17 Pain Relevance 0.17
The histamine H1 antagonists mepyramine and ketotifen and the calcium antagonists verapamil, nifedipine and TMB-8 were also ineffective in suppressing FMLP-induced elastase release.
Regulation (ineffective) of Negative_regulation (suppressing) of elastase associated with antagonist
2) Confidence 0.36 Published 1993 Journal Agents Actions Section Abstract Doc Link 8100381 Disease Relevance 0.54 Pain Relevance 0.44
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Regulation (resulted) of Negative_regulation (reduction) of HNE associated with stress
3) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.59 Pain Relevance 0.15
There is a significantly increased intensity of band 4 (serum protein), band 6 (Ig gamma-2), and band 9 (leukocyte elastase inhibitor) in SAC and PAC patients.
Regulation (intensity) of in band Negative_regulation (inhibitor) of elastase in leukocyte associated with heart rate under development and conjunctivitis
4) Confidence 0.04 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965574 Disease Relevance 1.03 Pain Relevance 0

General Comments

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