INT4631

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 8
Speculated 3
Reported most in Abstract
Documents 127
Total Number 130
Disease Relevance 17.37
Pain Relevance 83.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
neurons 9
stomach 6
plasma 6
brain 4
dorsal root ganglia 3
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 824 100.00 Very High Very High Very High
Calcitonin gene-related peptide 137 100.00 Very High Very High Very High
Neuropeptide 130 100.00 Very High Very High Very High
substance P 102 100.00 Very High Very High Very High
Cholecystokinin 81 100.00 Very High Very High Very High
Enkephalin 62 100.00 Very High Very High Very High
qutenza 60 100.00 Very High Very High Very High
agonist 48 100.00 Very High Very High Very High
Serotonin 11 100.00 Very High Very High Very High
Hyperalgesia 10 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 100.00 Very High Very High Very High
Generalized Anxiety Disorder 4 100.00 Very High Very High Very High
Toxicity 2 100.00 Very High Very High Very High
Hyperalgesia 11 99.96 Very High Very High Very High
Depression 65 99.74 Very High Very High Very High
INFLAMMATION 17 99.62 Very High Very High Very High
Neuropathic Pain 8 99.56 Very High Very High Very High
Aging 10 99.28 Very High Very High Very High
Nociception 39 99.18 Very High Very High Very High
Obesity 16 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of the anti-inflammatory analgesic, sodium diclofenac (3 mg.kg-1.d-1), abolished an adjuvant-induced increase in the content of immunoreactive somatostatin in the dorsal root ganglia.
Positive_regulation (increase) of somatostatin in dorsal root ganglia associated with inflammation, analgesic, somatostatin and diclofenac
1) Confidence 0.70 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.42 Pain Relevance 1.13
Somatostatin is increased in the dorsal root ganglia of adjuvant-inflamed rat.
Positive_regulation (increased) of Somatostatin in dorsal root ganglia associated with somatostatin
2) Confidence 0.70 Published 1990 Journal Neurosci. Res. Section Title Doc Link 1977111 Disease Relevance 0.38 Pain Relevance 0.92
The adjuvant inoculation, which produced long-lasting inflammation and hyperalgesia, increased the content of immunoreactive somatostatin, especially somatostatin-14, in the dorsal root ganglia at L4-L6 levels with no change in the dorsal and ventral horns of lumbar enlargement.
Positive_regulation (increased) of somatostatin in ventral associated with hyperalgesia, inflammation and somatostatin
3) Confidence 0.70 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.36 Pain Relevance 0.90
The adjuvant inoculation, which produced long-lasting inflammation and hyperalgesia, increased the content of immunoreactive somatostatin, especially somatostatin-14, in the dorsal root ganglia at L4-L6 levels with no change in the dorsal and ventral horns of lumbar enlargement.
Positive_regulation (increased) of somatostatin-14 in ventral associated with hyperalgesia, inflammation and somatostatin
4) Confidence 0.70 Published 1990 Journal Neurosci. Res. Section Abstract Doc Link 1977111 Disease Relevance 0.42 Pain Relevance 0.96
Following a 3-h interval, a second stimulation by veratridine also increased somatostatin levels (43%).
Positive_regulation (increased) of somatostatin associated with somatostatin
5) Confidence 0.70 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.63
The addition of veratridine (100 microM) in the perfusion medium increased the somatostatin levels recovered from the striatum by 85% (P < 0.01).
Positive_regulation (increased) of somatostatin in striatum associated with somatostatin
6) Confidence 0.70 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.57
Stimulation with 100 mM KCl increased the recovered somatostatin by 138% (P < 0.05).
Positive_regulation (increased) of somatostatin associated with somatostatin
7) Confidence 0.70 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.42
A second stimulation following a 3-h interval increased the somatostatin levels by approximately 60%.
Positive_regulation (increased) of somatostatin associated with somatostatin
8) Confidence 0.70 Published 1993 Journal Neuroscience Section Abstract Doc Link 8101642 Disease Relevance 0 Pain Relevance 0.52
Substance P levels increased significantly in both sympathetic and sensory neurons after explantation, and somatostatin levels increased in sympathetic neurons.
Positive_regulation (increased) of somatostatin in neurons associated with somatostatin and substance p
9) Confidence 0.70 Published 1983 Journal Neuroscience Section Abstract Doc Link 6192361 Disease Relevance 0.16 Pain Relevance 0.50
Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor.
Positive_regulation (activation) of somatostatin in nasal mucosa associated with ganglion cysts, dorsal horn, somatostatin and trigeminal ganglion neurons
10) Confidence 0.70 Published 2007 Journal Neuroscience Section Title Doc Link 17706880 Disease Relevance 0.62 Pain Relevance 1.26
It thus appears that the structural requirements for toxicity and somatostatin activity can be differentiated from those for opiate activity.
Positive_regulation (requirements) of somatostatin associated with toxicity, somatostatin and opiate
11) Confidence 0.69 Published 1987 Journal Peptides Section Abstract Doc Link 2893361 Disease Relevance 0.19 Pain Relevance 1.13
However, when administered in a dose of 10 . 0 microgram, both peptides significantly increased plasma somatostatin, by 31 and 22% respectively. 4.
Positive_regulation (increased) of somatostatin in plasma associated with somatostatin
12) Confidence 0.69 Published 1981 Journal Clin. Sci. Section Abstract Doc Link 6170487 Disease Relevance 0 Pain Relevance 0.56
Both SKF 38393 and quinpirole, when given alone, tended to decrease the haloperidol-induced increase in somatostatin levels; when both D1 and D2 agonists were administered together, somatostatin levels declined significantly.
Positive_regulation (increase) of somatostatin associated with agonist and somatostatin
13) Confidence 0.68 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883854 Disease Relevance 0 Pain Relevance 0.87
Fifteen minutes after injection of urethane, somatostatin messenger RNA concentrations were increased by 128% compared with those in nontreated rats.
Positive_regulation (increased) of somatostatin associated with somatostatin
14) Confidence 0.68 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0.10 Pain Relevance 0.50
The significant elevation of somatostatin messenger RNA was maintained for 2 hours after injection.
Positive_regulation (elevation) of somatostatin associated with somatostatin
15) Confidence 0.68 Published 1990 Journal Gastroenterology Section Abstract Doc Link 1974217 Disease Relevance 0.09 Pain Relevance 0.51
Inhibition of secretion in vivo and lack of stimulation of amylase secretion in isolated acini suggest that the somatostatin effect in vivo is mediated by an indirect effect similar to other peptides, for example, opiates and neurotensin.
Positive_regulation (mediated) of somatostatin associated with somatostatin and opiate
16) Confidence 0.68 Published 1986 Journal Dig. Dis. Sci. Section Abstract Doc Link 2421987 Disease Relevance 0 Pain Relevance 0.50
We conclude that somatostatin exerts a direct postsynaptic effect on neostriatal neurons via the activation of somatostatin receptors.
Positive_regulation (activation) of somatostatin in neurons associated with somatostatin
17) Confidence 0.67 Published 2002 Journal Neuroscience Section Abstract Doc Link 11823066 Disease Relevance 0 Pain Relevance 0.82
The results showed that subcutaneous injection of formalin in the right hindpaw increased c-fos-like immunoreactivity (FLI), somatostatin-like immunoreactivity (Som-LI), Som-LI/FLI and perprosomatostatin mRNA (PPS-mRNA) in neurones of right spinal dorsal horn and significantly enhanced pain intensity rating.
Positive_regulation (increased) of somatostatin in dorsal horn associated with pain, spinal dorsal horn and somatostatin
18) Confidence 0.67 Published 1999 Journal Sheng Li Xue Bao Section Abstract Doc Link 11972177 Disease Relevance 0.34 Pain Relevance 0.82
While much of the insensitivity to GRF may be mediated by the increased somatostatin tone reported in aging rats, a diminished pituitary cAMP response to GRF may also be an important etiological factor in the hyposomatotropinemia of the aging male rat.
Positive_regulation (increased) of somatostatin in pituitary associated with aging and somatostatin
19) Confidence 0.67 Published 1986 Journal Endocrinology Section Abstract Doc Link 3009151 Disease Relevance 0.42 Pain Relevance 0.05
In 8-week-old obese rats, a decrease of GH pituitary content and an increase of hypothalamic somatostatin (SRIF) concentration were observed.
Positive_regulation (increase) of somatostatin in pituitary associated with obesity and somatostatin
20) Confidence 0.67 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 2139233 Disease Relevance 1.05 Pain Relevance 0.10

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