INT46311

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Context Info
Confidence 0.27
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.51
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
blood 2
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 96.16 Very High Very High Very High
methotrexate 28 92.56 High High
Inflammation 17 91.72 High High
Inflammatory marker 4 88.48 High High
anesthesia 2 75.32 Quite High
rheumatoid arthritis 28 58.00 Quite High
corticosteroid 2 53.28 Quite High
Crohn's disease 35 45.92 Quite Low
withdrawal 1 32.96 Quite Low
spastic colon 24 14.56 Low Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 6 99.84 Very High Very High Very High
Experimental Liver Neoplasms 2 99.04 Very High Very High Very High
INFLAMMATION 18 91.72 High High
Inflammatory Bowel Disease 83 89.48 High High
Disease 83 73.00 Quite High
Rheumatoid Arthritis 28 58.00 Quite High
Cancer 8 57.48 Quite High
Mycobacterial Infection 4 51.48 Quite High
Nicotine Addiction 13 46.40 Quite Low
Congenital Anomalies 1 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Examples of such changes are the fluctuations in the levels of CRP, SAA, TNF-?
Regulation (fluctuations) of Gene_expression (levels) of SAA
1) Confidence 0.27 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2964606 Disease Relevance 0.70 Pain Relevance 0.20
Noteworthy aspects of treatment with tocilizumab are that SAA and CRP levels were normalized in nearly all the patients in whom pre-infusion trough levels of the drug can be detected in blood, that is, tocilizumab can be measured in blood before treatment.
Regulation (normalized) of Gene_expression (levels) of SAA in blood
2) Confidence 0.14 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.11 Pain Relevance 0.18
The effect of pyridoxine depletion on the expression of serum protein species in control and Morris hepatoma No. 7777-bearing rats was studied with polyacrylamide gel electrophoresis (PAGE).
Regulation (effect) of Gene_expression (expression) of serum protein associated with experimental liver neoplasms
3) Confidence 0.03 Published 1981 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 6935482 Disease Relevance 0.25 Pain Relevance 0.06
Effects of pyridoxine on serum protein expression in hepatoma-bearing rats.
Regulation (Effects) of Gene_expression (expression) of serum protein associated with hepatocellular cancer
4) Confidence 0.03 Published 1981 Journal J. Natl. Cancer Inst. Section Title Doc Link 6935482 Disease Relevance 0.45 Pain Relevance 0.08

General Comments

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