INT46332

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Context Info
Confidence 0.34
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 12
Disease Relevance 5.63
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
spinal 1
cleavage 1
ECM 1
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 87 100.00 Very High Very High Very High
palliative 88 99.60 Very High Very High Very High
cytokine 18 97.64 Very High Very High Very High
fibrosis 52 93.96 High High
Angina 7 79.04 Quite High
Pain 5 62.88 Quite High
Inflammation 48 54.84 Quite High
Migraine 2 50.00 Quite Low
menstrual migraine 1 50.00 Quite Low
backache 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 88 100.00 Very High Very High Very High
Infarction 5 99.68 Very High Very High Very High
Cancer 403 99.56 Very High Very High Very High
Death 31 96.96 Very High Very High Very High
Hyperplasia 1 94.60 High High
Fibrosis 39 93.96 High High
Stress 10 93.84 High High
Hepatocellular Cancer 116 92.72 High High
Sprains And Strains 3 89.76 High High
Metastasis 95 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP2 activity detected by ELISA
MMP2 Binding (activity) of
1) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.08 Pain Relevance 0
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
MMP2 Binding (activity) of associated with cancer and palliative
2) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.54
Metalloproteinase 2 (MMP2), and tissue inhibitor of metalloproteinase 1 (TIMP1) transcript levels were determined by a ribonuclease protection assay (RiboQuant™, Becton, Dickinson and Company, Franklin Lakes, NJ).


MMP2 Spec (determined) Binding (determined) of associated with metalloproteinase
3) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.25 Pain Relevance 0.13
METHODS: Data from 2 Phase III AT trials (AT1: randomized, placebo controlled, 1 attack; AT2: 12-months, noncomparative, open label) and 3 Phase IIIb STP trials in MM (MMP1 and MMP2: randomized, placebo controlled, double blind, 3 perimenstrual periods; MMP3: open label, noncomparative, 12 perimenstrual periods) were analyzed.
MMP2 Binding (blind) of
4) Confidence 0.13 Published 2010 Journal Gend Med Section Body Doc Link 20435272 Disease Relevance 0.08 Pain Relevance 0
Secondly, THL could inhibit the activity of MMP-2 directly (Fig 2B).
MMP-2 Binding (activity) of associated with metalloproteinase
5) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 1.60 Pain Relevance 0.14
MMP2 is also elevated post MI [109] and is associated with poor prognosis [110].
MMP2 Binding (associated) of associated with myocardial infarction
6) Confidence 0.13 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.92 Pain Relevance 0.20
Furthermore, 30 disc specimens obtained during spinal surgery were used for in situ hybridization of MMP-2 and -3-mRNA.
MMP-2 Binding (hybridization) of in spinal
7) Confidence 0.12 Published 2002 Journal Eur Spine J Section Abstract Doc Link 12193991 Disease Relevance 0.40 Pain Relevance 0.29
Furthermore, recent studies have also indicated that L-arginine treatment decreases the activity of NF-kB and metalloproteinases MMP-2 and MMP-9, reduces beta-dystroglycan cleavage, and causes the translocations of utrophin and nNOS throughout the sarcolemma, thus promoting muscle membrane integrity and reducing fibrosis in dystrophic muscle [21].
MMP-2 Binding (metalloproteinases) of in cleavage associated with fibrosis and metalloproteinase
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888587 Disease Relevance 0.43 Pain Relevance 0.20
MMP-2 can directly bind to ?
MMP-2 Binding (bind) of
9) Confidence 0.08 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.73 Pain Relevance 0.05
TSP-1 and TSP-2 bind matrix metalloproteinase-2, and thereby act to clear this matrix metalloproteinase from the pericellular ECM [5].
matrix metalloproteinase-2 Binding (bind) of in ECM associated with metalloproteinase
10) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.09 Pain Relevance 0.15
A new PGE2-gel, based on a cross-linked starch powder, has been developed.
PGE2-gel Binding (cross-linked) of
11) Confidence 0.02 Published 1981 Journal Arch. Gynecol. Section Abstract Doc Link 6949498 Disease Relevance 0.07 Pain Relevance 0.06
Enhanced cardiac production of matrix metalloproteinase-2 and -9 and its attenuation associated with pravastatin treatment in patients with acute myocardial infarction.
matrix metalloproteinase-2 Binding (associated) of associated with metalloproteinase and myocardial infarction
12) Confidence 0.01 Published 2007 Journal Clin. Sci. Section Title Doc Link 16939410 Disease Relevance 0.38 Pain Relevance 0.23

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