INT46333

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Context Info
Confidence 0.49
First Reported 1982
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.71
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Asrgl1) nucleus (Asrgl1) protein maturation (Asrgl1)
cytoplasm (Asrgl1)
Asrgl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 1 95.44 Very High Very High Very High
narcan 3 88.24 High High
Central nervous system 1 79.36 Quite High
headache 1 75.32 Quite High
depression 1 75.00 Quite High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 5 97.36 Very High Very High Very High
Intracranial Sinus Thrombosis 9 93.88 High High
Body Weight 3 91.96 High High
Lymphatic System Cancer 1 91.80 High High
Precursor Cell Lymphoblastic Leukemia-lymphoma 1 90.84 High High
Hodgkin's Disease 4 89.64 High High
Neuroblastoma 2 87.24 High High
Volume Depletion And Dehydration 1 82.88 Quite High
Anaplastic Large Cell Lymphoma 1 82.36 Quite High
Cancer 4 77.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The patient had previously received L-asparaginase, but the last dose had been given 4 months prior to the onset of pancreatitis.
Positive_regulation (received) of L-asparaginase associated with pancreatitis
1) Confidence 0.49 Published 1982 Journal Cancer Section Abstract Doc Link 6949626 Disease Relevance 0.44 Pain Relevance 0
Although D-amino acids, as antipeptidases have some effects through endorphinergic systems, D-Asp (an inhibitor of L-asparaginase) seems to act at the level of L-asparaginase presumably by increasing the level of endorphins since L-Asp antagonizes the inhibitory effect of both D-Asp and morphine.
Positive_regulation (level) of L-asparaginase associated with morphine
2) Confidence 0.39 Published 1982 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 7187048 Disease Relevance 0.32 Pain Relevance 0.21
No child had received L-asparaginase.
Positive_regulation (received) of L-asparaginase
3) Confidence 0.09 Published 1997 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 9251737 Disease Relevance 1.96 Pain Relevance 0.12

General Comments

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