INT46336

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Context Info
Confidence 0.53
First Reported 1982
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 4.91
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DNMT3B) nucleus (DNMT3B) DNA binding (DNMT3B)
cytoplasm (DNMT3B)
Anatomy Link Frequency
blood 1
endocrine glands 1
urine 1
DNMT3B (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 29 99.84 Very High Very High Very High
rheumatoid arthritis 73 97.60 Very High Very High Very High
tolerance 7 93.42 High High
Pain 20 91.76 High High
nud 2 87.84 High High
headache 5 84.08 Quite High
Dopamine 3 77.04 Quite High
Serotonin 1 76.52 Quite High
Glutamate 2 76.08 Quite High
gABA 6 75.64 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 33 99.84 Very High Very High Very High
Disease 81 99.76 Very High Very High Very High
Fever 8 99.44 Very High Very High Very High
Genomic Instability 1 97.76 Very High Very High Very High
Rheumatoid Arthritis 74 97.60 Very High Very High Very High
Injury 8 97.60 Very High Very High Very High
Schizophrenia 106 94.20 High High
Drug Dependence 43 94.08 High High
Toothache 2 92.88 High High
Pain 20 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No other factors analyzed (year of authorization by an institutional review board, the phase of the study, the inclusion of paediatric patients, or field of medical research) had an effect on ICF length.
Regulation (effect) of ICF
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868027 Disease Relevance 0 Pain Relevance 0
A Comprehensive ICF Core Set was selected for the comprehensive classification of functioning and a Brief ICF Core Set for application in trials.
Regulation (selected) of ICF
2) Confidence 0.38 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 19282309 Disease Relevance 0.14 Pain Relevance 0
A Comprehensive ICF Core Set was selected for the comprehensive classification of functioning and a Brief ICF Core Set for application in trials.
Regulation (selected) of ICF
3) Confidence 0.38 Published 2010 Journal Ann. Rheum. Dis. Section Body Doc Link 19282309 Disease Relevance 0.14 Pain Relevance 0
Confirmation of the ICF categories contained in the Comprehensive ICF Core Set for RA
Regulation (Confirmation) of ICF associated with rheumatoid arthritis
4) Confidence 0.37 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779412 Disease Relevance 0.35 Pain Relevance 0.17
Also, other possible confounders such as the cultural settings and evaluators' professional backgrounds may influence the ICF measurement values.
Spec (may) Regulation (influence) of ICF
5) Confidence 0.37 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1199614 Disease Relevance 0.22 Pain Relevance 0
In our study, we could not rule out an influence of antipsychotic dosing on ICF completely, as we detected a positive correlation between the extent of facilitation (MEP ratio) and the cumulative antipsychotic dosage in the SZ-SUD patient group.
Regulation (influence) of ICF associated with drug dependence and schizophrenia
6) Confidence 0.14 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.28 Pain Relevance 0.33
It has been demonstrated that DNMT1, DNMT3A, and DNMT3B are disregulated in endometriosis [48], and it has been suggested that aberrant methylation of HOXA10 and of the progesterone receptor PR-B may be responsible of the disregulation of their expression in endometriosis.
Regulation (disregulated) of DNMT3B associated with endometriosis
7) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2837904 Disease Relevance 0.91 Pain Relevance 0.24
These data are a measure at the ICF level of participation and will inform the investigators of periods of illness or injury that could affect data interpretation.
Regulation (participation) of ICF associated with injury
8) Confidence 0.10 Published 2007 Journal BMC Pediatr Section Body Doc Link PMC1838902 Disease Relevance 0.18 Pain Relevance 0
Secondary objectives of the FACTS-2-FSHD trial are:

- to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.


Regulation (participation) of ICF in urine associated with pain, tolerance, fatigue and sprains and strains
9) Confidence 0.03 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.32 Pain Relevance 0.14
The medicinal plants that were presumed to be effective in treating a certain category of disease, such as 'mich' and febrile diseases (0.80) had higher ICF values.
Regulation (values) of ICF associated with fever and disease
10) Confidence 0.03 Published 2007 Journal J Ethnobiol Ethnomedicine Section Abstract Doc Link PMC1852296 Disease Relevance 0.75 Pain Relevance 0
Frequency of contraction and ICF were not affected by imidazole treatment despite TXB2 reduction.
Neg (not) Regulation (affected) of ICF
11) Confidence 0.03 Published 1982 Journal Biol. Reprod. Section Abstract Doc Link 6950795 Disease Relevance 0.07 Pain Relevance 0.07
The ICF value for this group was 0.40, considered low.
Regulation (value) of ICF
12) Confidence 0.01 Published 2005 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC1291389 Disease Relevance 0.57 Pain Relevance 0
The use category with the lowest ICF value was "diseases of the endocrine glands, metabolism, and nutrition" (0.14).
Regulation (value) of ICF in endocrine glands associated with disease
13) Confidence 0.01 Published 2005 Journal J Ethnobiol Ethnomed Section Body Doc Link PMC1291389 Disease Relevance 0.67 Pain Relevance 0.16
Secondary objectives of the FACTS-2-FSHD trial are:

- to evaluate the effects of AET and CBT on bodily functions and structures as defined by the International Classification of Functioning, Disability and Health (ICF): lower extremity muscle strength, pain, psychological well being, cardiovascular risk factors, aerobic exercise tolerance, sleeping pattern, as well as biomarkers in blood and urine and structural and metabolic muscle tissue characteristics. - to evaluate the effects of AET and CBT on the ICF level of activities: physical activity in daily life, self perceived functional status, and fall incidence. - to evaluate the effects of AET and CBT on the ICF level of participation: limitations in participation and autonomy and quality of life. - to evaluate the effects of AET and CBT on environmental and personal factors as defined by the ICF: coping style, illness cognitions, concentration problems, motivation, caregiver strain, experienced fatigue of the caregiver, social support and coping of the caregiver.


Regulation (participation) of ICF in blood associated with pain, tolerance, fatigue and sprains and strains
14) Confidence 0.01 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2906431 Disease Relevance 0.32 Pain Relevance 0.14

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