INT46350

Context Info Confidence 0.65 First Reported 1982 Last Reported 2009 Negated 2 Speculated 0 Reported most in Body Documents 32 Total Number 32 Disease Relevance 29.39 Pain Relevance 4.55

cytosol (Msr1) plasma membrane (Msr1)

Anatomy Link Frequency hearts 3 macrophages 2 Kupffer cells 2 endothelial cells 2 nerve 2 Msr1 (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 27 100.00 Potency 4 100.00 antidepressant 4 99.96 agonist 29 99.78 Spinal cord 12 99.68 Neuropathic pain 8 99.00 Inflammation 60 98.76 Cannabinoid 87 98.64 Cannabinoid receptor 17 97.72 antinociception 2 95.88

Disease Link Frequency Relevance Heat Targeted Disruption 295 100.00 Diabetes Mellitus 634 99.32 Injury 143 99.28 Neuropathic Pain 10 99.00 Apoptosis 58 98.80 INFLAMMATION 62 98.76 Tremor 20 98.68 Aids-related Complex 2 98.28 Spasticity 102 98.20 Atherosclerosis 51 98.14

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This is curious, because acLDL is endocytosed by MSR-A, as is oxLDL.

Gene_expression (endocytosed) of MSR-A

1) Confidence 0.65 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.38 Pain Relevance 0

The SR-A receptors occur in two different forms that are generated by alternative splicing of the primary transcript: SR-AI and SR-AII.

Gene_expression (occur) of SR-A

2) Confidence 0.65 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.82 Pain Relevance 0.09

This shows that the lack of SR-A receptors does not affect the establishment of a protective immune response against RAS.

Neg (lack) Gene_expression (lack) of SR-A

3) Confidence 0.65 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 0.80 Pain Relevance 0.03

SR-AI and II receptors are expressed by both activated macrophages and glial cells.

Gene_expression (expressed) of SR-AI in glial cells

4) Confidence 0.41 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.26 Pain Relevance 0.05

The initial targeting of sporozoites to the liver involves close interactions with sinusoidal endothelial cells and Kupffer cells [2], both of which express SR-AI and SR-AII receptors.

Gene_expression (express) of SR-AII in Kupffer cells

5) Confidence 0.41 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.00 Pain Relevance 0

The initial targeting of sporozoites to the liver involves close interactions with sinusoidal endothelial cells and Kupffer cells [2], both of which express SR-AI and SR-AII receptors.

Gene_expression (express) of SR-AI in Kupffer cells

6) Confidence 0.41 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.00 Pain Relevance 0

The SR-A receptors occur in two different forms that are generated by alternative splicing of the primary transcript: SR-AI and SR-AII.

Gene_expression (occur) of SR-AI

7) Confidence 0.36 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.83 Pain Relevance 0.09

The SR-A receptors occur in two different forms that are generated by alternative splicing of the primary transcript: SR-AI and SR-AII.

Gene_expression (occur) of SR-AII

8) Confidence 0.36 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.83 Pain Relevance 0.09

Msr proteins are highly expressed in liver and kidney tissues, suggesting their overall importance in detoxification and therefore maintenance of cellular resistance to oxidative protein damage (Moskovitz et al. 2001; Moskovitz 2005).

Gene_expression (expressed) of Msr in kidney

9) Confidence 0.35 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.12 Pain Relevance 0

The 5-HT precursor l-5-hydroxytryptophan (L-5-HTP) depressed MSR in the spinal cord injured rats but not in normal rats.

Neg (not) Gene_expression (depressed) of MSR in spinal cord associated with spinal cord

10) Confidence 0.32 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16806182 Disease Relevance 0.52 Pain Relevance 0.33

In the present study, a series of SR141716A analogs were synthesized and were tested for CB(1) binding affinity and in a battery of in vivo tests, including hypomobility, antinociception, and hypothermia in mice.

Gene_expression (synthesized) of SR141716A associated with antinociception and hypothermia

11) Confidence 0.25 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181936 Disease Relevance 0.10 Pain Relevance 0.37

Synthesis of an antagonist, SR141716A, that selectively binds to brain cannabinoid (CB(1)) receptors without producing cannabimimetic activity in vivo, suggests that recognition and activation of cannabinoid receptors are separable events.

Gene_expression (Synthesis) of SR141716A in brain associated with cannabinoid receptor, cannabinoid and antagonist

12) Confidence 0.22 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11181936 Disease Relevance 0.07 Pain Relevance 0.28

Transgenic (Tg) DN MSR RAGE and Tg DN PPET RAGE mice were prepared and characterized as previously described (20,22).

Gene_expression (prepared) of DN MSR associated with targeted disruption

13) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 0.67 Pain Relevance 0

We observed that in diabetic RAGE KO, Tg DN PPET RAGE, and Tg DN MSR RAGE mice hearts, protection from injury due to I/R was also associated with reductions in caspase-3 activation and cytochrome c release.

Gene_expression (hearts) of DN MSR in hearts associated with targeted disruption, diabetes mellitus and injury

14) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.22 Pain Relevance 0

We examined the levels of specific AGEs, CML, pentosidine, and furosine (glycated lysine) in diabetic wild-type, RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE heart under baseline conditions and after I/R (Table 2).

Gene_expression (heart) of DN MSR in heart associated with targeted disruption, myeloid leukemia and diabetes mellitus

15) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 2.90 Pain Relevance 0.03

Interestingly, after I/R, CML levels were significantly greater in diabetic WT hearts in comparison with diabetic RAGE-KO, Tg DN PPET RAGE, and Tg DN MSR RAGE hearts (Table 2).

Gene_expression (hearts) of DN MSR in hearts associated with targeted disruption, myeloid leukemia and diabetes mellitus

16) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2453611 Disease Relevance 3.20 Pain Relevance 0

The initial targeting of sporozoites to the liver involves close interactions with sinusoidal endothelial cells and Kupffer cells [2], both of which express SR-AI and SR-AII receptors.

Gene_expression (express) of SR-AII in endothelial cells

17) Confidence 0.14 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.00 Pain Relevance 0

The initial targeting of sporozoites to the liver involves close interactions with sinusoidal endothelial cells and Kupffer cells [2], both of which express SR-AI and SR-AII receptors.

Gene_expression (express) of SR-AI in endothelial cells

18) Confidence 0.14 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.00 Pain Relevance 0

SR-AI and II receptors are expressed by both activated macrophages and glial cells.

Gene_expression (expressed) of SR-AI in macrophages

19) Confidence 0.14 Published 2006 Journal BMC Microbiol Section Body Doc Link PMC1562429 Disease Relevance 1.26 Pain Relevance 0.05

Where clinical doubt exists, the value of nerve biopsy in distinguishing HSN types I and II is emphasized.

Gene_expression (distinguishing) of HSN types I and II in nerve

20) Confidence 0.13 Published 1982 Journal Brain Section Abstract Doc Link 6958343 Disease Relevance 0.34 Pain Relevance 0.21

General Comments

This test has worked.