INT46357

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Context Info
Confidence 0.45
First Reported 1980
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.10
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
liver 2
cortex 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 9 90.08 High High
midbrain 2 86.40 High High
fluoxetine 1 81.92 Quite High
Neurotransmitter 7 63.12 Quite High
parabrachial 1 51.04 Quite High
anesthesia 2 50.00 Quite Low
Substantia nigra 1 49.68 Quite Low
noradrenaline 1 35.40 Quite Low
medulla 1 32.32 Quite Low
GABAergic 2 5.28 Low Low
Disease Link Frequency Relevance Heat
Liver Failure 10 99.64 Very High Very High Very High
Hepatic Encephalopathy 17 97.76 Very High Very High Very High
Hyperammonemia 4 85.68 High High
Cirrhosis 19 76.48 Quite High
Targeted Disruption 1 75.84 Quite High
Cognitive Disorder 15 73.68 Quite High
Liver Disease 8 69.20 Quite High
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low
Shock 2 5.00 Very Low Very Low Very Low
Gliosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in hippocampal Ach and Ch levels were observed in both cognition markedly impaired group and cognition lightly impaired group, accompanied by performance failure in water maze test.
Regulation (Changes) of Gene_expression (levels) of Ach
1) Confidence 0.45 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095350 Disease Relevance 0.07 Pain Relevance 0
These results support the suggestion that barbiturates primarily inhibit the Ca-dependent stimulated release of ACh and affect ACh synthesis only indirectly.
Regulation (affect) of Gene_expression (synthesis) of ACh
2) Confidence 0.24 Published 1980 Journal Neurochem. Res. Section Abstract Doc Link 6968410 Disease Relevance 0 Pain Relevance 0.16
In intact rats the application of drugs to manipulate the excitability of ACh projections to cortex from the NbM produces correlated changes in the performance of attention tasks [11].
Regulation (excitability) of Gene_expression (projections) of ACh in cortex
3) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2257968 Disease Relevance 0 Pain Relevance 0.03
BDL rats, an animal model of liver failure, showed the same degree of alteration in both, AChE and ACh levels, as the BDL + HD animals, a model of liver failure and HE.
Regulation (degree) of Gene_expression (levels) of ACh in liver associated with liver failure and hepatic encephalopathy
4) Confidence 0.07 Published 2008 Journal Brain Section Body Doc Link PMC2577805 Disease Relevance 1.03 Pain Relevance 0.08

General Comments

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