INT46369

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Context Info
Confidence 0.09
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AK1) small molecule metabolic process (AK1) cytoplasm (AK1)
Anatomy Link Frequency
eyes 1
heart 1
AK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 137 99.68 Very High Very High Very High
Pain management 20 96.80 Very High Very High Very High
cINOD 13 94.04 High High
COX-2 inhibitor 8 88.84 High High
aspirin 6 85.68 High High
acular 2 82.60 Quite High
cytokine 1 76.96 Quite High
Inflammation 6 64.72 Quite High
Opioid 74 38.88 Quite Low
Analgesic 44 33.32 Quite Low
Disease Link Frequency Relevance Heat
Cancer Pain 53 96.36 Very High Very High Very High
Pain 158 84.24 Quite High
Microphthalmia 1 79.52 Quite High
Solid Tumor 1 74.32 Quite High
Myopia 38 71.12 Quite High
Disease Progression 2 70.64 Quite High
Renal Insufficiency 4 68.76 Quite High
Cancer 62 66.08 Quite High
Hemorrhage 4 64.80 Quite High
INFLAMMATION 7 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four proteins that were also upregulated in the MD eyes included adenylate kinase 1 (AK1) that catalyzes conversion between ATP and AMP molecules and presumably indicates a need for more energy during scleral remodelling, ?
Positive_regulation (upregulated) of AK1 in eyes
1) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994335 Disease Relevance 0.33 Pain Relevance 0
These drugs specifically inhibit the COX-2 isoenzyme, which is considered the inducible isoenzyme during painful stimuli.
Positive_regulation (inducible) of isoenzyme associated with pain
2) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.91 Pain Relevance 0.94
Most probably the BB isoenzyme is liberated mainly from the saphenous vein as a consequence of the surgical manipulations during the heart operation.
Positive_regulation (liberated) of BB isoenzyme in heart
3) Confidence 0.01 Published 1981 Journal Clin. Chim. Acta Section Abstract Doc Link 6971717 Disease Relevance 0 Pain Relevance 0

General Comments

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