INT4637

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Context Info
Confidence 0.41
First Reported 1976
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 132
Total Number 137
Disease Relevance 14.48
Pain Relevance 67.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
brain 15
spinal cord 4
neurons 4
tail 2
striatum 2
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 187 100.00 Very High Very High Very High
nMDA receptor 117 100.00 Very High Very High Very High
Opioid 107 100.00 Very High Very High Very High
substance P 103 100.00 Very High Very High Very High
Dopamine 98 100.00 Very High Very High Very High
opioid receptor 96 100.00 Very High Very High Very High
opiate 85 100.00 Very High Very High Very High
Enkephalin 71 100.00 Very High Very High Very High
fortral 70 100.00 Very High Very High Very High
gABA 37 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 22 100.00 Very High Very High Very High
Respiratory Tract Infection 4 100.00 Very High Very High Very High
Bordatella Infection 9 99.76 Very High Very High Very High
Depression 2 99.64 Very High Very High Very High
Dystonia 11 99.60 Very High Very High Very High
Stress 27 99.42 Very High Very High Very High
Neuroblastoma 10 99.12 Very High Very High Very High
Pressure Volume 2 Under Development 12 98.96 Very High Very High Very High
INFLAMMATION 12 98.94 Very High Very High Very High
Pain 94 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined the interaction of antidepressants with 5-HT1A receptors using the forced swim test in rats using both (+/-)-pindolol and the selective 5-HT1A receptor antagonist WAY 100,635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(pyridinyl) cyclohexanecarboxamide trihydrochloride) in combination with either fluoxetine or the selective monoamine oxidase-A inhibitor befloxatone. 8-Hydroxy-dipropylaminotetralin (8-OH-DPAT; 0.125-1 mg/kg s.c.), used as a reference for 5-HT1A agonist activity, reduced immobility in the forced swim test and this effect was significantly antagonised by WAY 100,635.
receptors Spec (examined) Binding (interaction) of associated with antidepressant, antagonist, eae, agonist, monoamine and fluoxetine
1) Confidence 0.41 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10395092 Disease Relevance 0 Pain Relevance 0.66
Three (+)-benzomorphans that bind to sigma receptors produced dystonia in a dose-related manner when microinjected into the red nucleus of rats.
receptors Binding (bind) of in red nucleus associated with dystonia
2) Confidence 0.36 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2161543 Disease Relevance 0.17 Pain Relevance 0.10
The only ligand in this study that binds with high affinity to sigma receptors, but failed to elicit torsional head movements was (+)-[3-(3-hydroxyphenyl)-N-(1-propyl)piperidine] [(+)-3PPP], a ligand with mixed activity at sigma and dopamine receptors.
receptors Binding (binds) of in head associated with dopamine receptor
3) Confidence 0.36 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2161543 Disease Relevance 0.23 Pain Relevance 0.18
Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions.
receptors Binding (Characterization) of in nucleus accumbens associated with nucleus accumbens, enkephalin and opioid receptor
4) Confidence 0.32 Published 1989 Journal Brain Res. Section Title Doc Link 2558779 Disease Relevance 0 Pain Relevance 0.52
We suggest that formalin attenuates epinephrine secretion from the adrenal medulla most probably via irritation of s.c. somatosensory receptors.
receptors Binding (irritation) of in adrenal medulla associated with medulla
5) Confidence 0.32 Published 2005 Journal J. Neuroendocrinol. Section Abstract Doc Link 16219001 Disease Relevance 0.36 Pain Relevance 0.14
Using K+ phosphate buffer with 25 nM spiperone, [3H]YM-09151-2 binding showed a high affinity for sigma receptors but no affinity for D2 dopamine or 5-HT1A receptors in rat brain.
receptors Neg (no) Binding (affinity) of in brain associated with dopamine
6) Confidence 0.32 Published 1996 Journal Neuroreport Section Abstract Doc Link 8804051 Disease Relevance 0 Pain Relevance 0.12
Repeated administrations of 7.5 mg/kg of pentazocine (for 14 days) resulted in a significant decrease in the affinity of 3H-haloperidol binding to rat cortical sigma receptors without any changes in the maximal number of binding sites (Bmax).
receptors Binding (binding) of associated with fortral
7) Confidence 0.31 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1850284 Disease Relevance 0 Pain Relevance 0.25
Sertraline and clorgyline, two antidepressant drugs with a high affinity for receptors, also potentiate, at low doses, the NMDA response; however, when administered at higher sigma doses, the degree of potentiation induced by these two ligands progressively decreases (Bergeron et al. 1993).
receptors Binding (affinity) of associated with antidepressant
8) Confidence 0.31 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7609778 Disease Relevance 0 Pain Relevance 0.18
Cyclazocine, a benzomorphan derivative, with high affinity for sigma receptors, was able to produce a complete generalization to DM, without a change in the number of rats responding.
receptors Binding (affinity) of
9) Confidence 0.30 Published 1995 Journal Biomed. Pharmacother. Section Abstract Doc Link 8746072 Disease Relevance 0 Pain Relevance 0.45
None of the compounds was able to irreversibly inhibit binding of [3H]bremazocine to guinea pig and rat brain membranes (depleted of functional mu and delta receptors by pretreatment with acylating agents BIT and FIT).
receptors Binding (binding) of in brain
10) Confidence 0.30 Published 1990 Journal J. Med. Chem. Section Abstract Doc Link 2157008 Disease Relevance 0 Pain Relevance 0.04
These parameters were measured in parallel, by means of a competitive radioimmunoassay with double antibodies (Peninsula Lab.). 5-LE probably bound to both mu and delta receptors, since its effect on the CT secretion was reversed by 13 micrograms of naloxone (i.c.v.).
receptors Binding (bound) of associated with narcan
11) Confidence 0.28 Published 1993 Journal Rom J Endocrinol Section Abstract Doc Link 7909701 Disease Relevance 0 Pain Relevance 0.41
The concentration of kappa receptors was investigated in the hypothalamus, amygdala, mesencephalon, corpus striatum, hippocampus, thalamus, frontal poles, anterior and posterior cortex collected from male rats of 2 and 19 months of age. 3H-bremazocine (BRZ) was used as the ligand of kappa receptors, after protection of mu and delta receptors respectively with dihydromorphine and d-ala-d-leu-enkephalin.
receptors Binding (ligand) of in hypothalamus associated with enkephalin, thalamus, hippocampus and amygdala
12) Confidence 0.26 Published 1989 Journal Life Sci. Section Abstract Doc Link 2557515 Disease Relevance 0.14 Pain Relevance 0.52
In animals which showed almost total loss of GABAB receptors. 125I-Bolton Hunter CCK binding in the IPN was reduced from 1.83 +/- 0.28 pmol/g wet weight to 0.87 +/- 0.16 pmol/g wet weight.
receptors Binding (binding) of in IPN associated with ipn
13) Confidence 0.24 Published 1988 Journal Brain Res. Section Abstract Doc Link 3408996 Disease Relevance 0 Pain Relevance 0.41
Since activation of either supraspinal or spinal alpha(2) adrenergic receptors can induce antinociception, and since improgan showed affinity for these receptors in vitro, the effects of the alpha(2) antagonist yohimbine on improgan antinociception were presently studied in rats on the hot plate and tail flick tests.
receptors Binding (affinity) of in tail associated with antinociception, antagonist and tail-flick
14) Confidence 0.24 Published 2001 Journal Brain Res. Section Abstract Doc Link 11743967 Disease Relevance 0 Pain Relevance 1.02
Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat.
receptors Binding (association) of in visceral
15) Confidence 0.21 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6319664 Disease Relevance 0 Pain Relevance 1.09
The results suggest a functional interaction between delta and mu receptors in the postnatal period but not between delta and kappa receptors.
receptors Binding (interaction) of
16) Confidence 0.17 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9972857 Disease Relevance 0 Pain Relevance 0.73
The results suggest a functional interaction between delta and mu receptors in the postnatal period but not between delta and kappa receptors.
receptors Binding (interaction) of
17) Confidence 0.17 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9972857 Disease Relevance 0 Pain Relevance 0.73
As several neuroactive steroids such as progesterone and testosterone have a high affinity for sigma receptors, the effects of some neuroactive steroids on the NMDA-induced neuronal response were assessed using extracellular unitary recordings of CA3 dorsal hippocampus pyramidal neurons obtained in anesthetized Sprague-Dawley rats.
receptors Binding (affinity) of in dorsal associated with pyramidal cell and hippocampus
18) Confidence 0.17 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8943785 Disease Relevance 0 Pain Relevance 0.29
The data also suggest differences in the delta and mu receptors interacting in the modulation of antinociception and those involved in behavioral responses in the open field.
receptors Binding (interacting) of associated with antinociception
19) Confidence 0.17 Published 1999 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9972857 Disease Relevance 0 Pain Relevance 0.69
[3H]DSTBULET, a new linear hexapeptide with both an improved selectivity and a high affinity for delta-opioid receptors.
receptors Binding (affinity) of associated with enkephalin and delta opioid receptors
20) Confidence 0.14 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2828972 Disease Relevance 0 Pain Relevance 0.40

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