INT46384

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Context Info
Confidence 0.41
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.87
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
MCF-7 1
nucleus 1
vertex 1
TRGC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 4 99.28 Very High Very High Very High
Crohn's disease 5 96.40 Very High Very High Very High
Neurotransmitter 5 91.84 High High
headache 9 91.24 High High
Migraine 1 90.12 High High
abdominal pain 8 87.56 High High
Central nervous system 44 87.04 High High
substance P 1 79.12 Quite High
bradykinin 28 75.52 Quite High
Neuropeptide 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 94 100.00 Very High Very High Very High
Pressure And Volume Under Development 36 99.98 Very High Very High Very High
Urticaria 6 99.98 Very High Very High Very High
Angioedema 27 99.64 Very High Very High Very High
Disease 69 96.08 Very High Very High Very High
Reprotox - General 1 4 95.40 Very High Very High Very High
Neuroblastoma 36 93.92 High High
Syndrome 17 91.36 High High
Headache 8 91.24 High High
Systemic Lupus Erythematosus 3 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C1 inhibitor binds irreversibly in these pathways.
C1 Binding (binds) of
1) Confidence 0.41 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC2881905 Disease Relevance 1.09 Pain Relevance 0.04
The clinical observations in this family suggest that angioneurotic edema associated with C1' esterase inhibitor deficiency may be closely linked genetically with a familial form of Crohn's disease.
C1 Binding (associated) of associated with urticaria, crohn's disease and disease
2) Confidence 0.37 Published 2000 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10799088 Disease Relevance 0.97 Pain Relevance 0.31
Because initial studies showed a functional deficiency of C1 esterase inhibitor and low C4 levels, he was treated with danazol, an attenuated androgen that has proven to be effective in the treatment of angioedema associated with C1 esterase inhibitor deficiency.
C1 Binding (associated) of associated with pressure and volume under development and hereditary angioedema
3) Confidence 0.35 Published 1982 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 6977562 Disease Relevance 1.01 Pain Relevance 0.07
Although not directly comparable, response time seems similar to that reported for C1 inhibitor treatment, although recurrent angioedema seems to be less frequent with C1 inhibitor.18,19

Multiple attacks

C1 Binding (frequent) of associated with angioedema
4) Confidence 0.33 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941790 Disease Relevance 0.19 Pain Relevance 0
The central limb of the trigeminal vascular pathway is its projection to the trigeminal nucleus caudalis (TNC) and to the C1-C2 levels of the spinal cord.
C1 Binding (projection) of in nucleus associated with spinal cord
5) Confidence 0.23 Published 2002 Journal Cephalalgia Section Abstract Doc Link 11972578 Disease Relevance 0.18 Pain Relevance 0.46
EGF motifs have six conserved cysteine residues that form three disulfide bonds—between C1 and C3, C2 and C4, C5 and C6.
C1 Binding (bonds) of
6) Confidence 0.13 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2443751 Disease Relevance 0.29 Pain Relevance 0
In contrast, the P2 peak has its maximum amplitude over the vertex on electrodes FCz, Cz, CPz, Pz, F1–F4, FC1–FC4, C1–C4, CP1–CP4, and P1–P4.
C1 Binding (amplitude) of in vertex
7) Confidence 0.09 Published 2007 Journal Exp Brain Res Section Body Doc Link PMC2248215 Disease Relevance 0.06 Pain Relevance 0.06
That is to say, the class C is a transformation of the class C1 if and only if every instance c of C is at some earlier time an instance of C1, and there is no time at which it is an instance of both C and C1.
C1 Binding (transformation) of
8) Confidence 0.08 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175958 Disease Relevance 0 Pain Relevance 0
DNA isolation and KIR2DS5 and HLA-C C1/C2 group typing
C1 Binding (typing) of
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928722 Disease Relevance 0.38 Pain Relevance 0.13
E2, the overall energy balance for binding, and the experimentally measured IC50 for our novel compounds C1-C8.
C1 Binding (compounds) of
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879362 Disease Relevance 0.07 Pain Relevance 0.17
Introduction of a sulfate moiety on the carbamoyl group, resultingin the formation of C1 and C2 toxins, has been shown following incubation with G. catenatum homogenate [44,99].
C1 Binding (formation) of
11) Confidence 0.04 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.16 Pain Relevance 0
It also prevents spontaneous activation of C1 and binding to the zymogen forms of C1r and C1s [24].
C1 Binding (binding) of
12) Confidence 0.04 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0
We observed that nELAV RBPs recognized and bound C1, C2 and C6 sub-regions, while the C4-5 fragment did not form mRNP complexes with nELAV proteins (Fig. 6B).


C1 Binding (bound) of
13) Confidence 0.02 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.09 Pain Relevance 0.04
The UV cross-linking experiments allowed us to observe that C1, C2 and C6 sub-regions show affinity for nELAV proteins in vitro while, although C4-5 contains putative AREs, it does not bind to nELAV RBPs.
C1 Neg (not) Binding (bind) of
14) Confidence 0.02 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.16 Pain Relevance 0
The luciferase activity together with the RealTime PCR results in comparison to UV cross-linking data, suggest that the binding shown by C1 and C2 regions for nELAV may be not so effective in vivo as in the case of C6 region.
C1 Binding (binding) of
15) Confidence 0.02 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.14 Pain Relevance 0
The other fragments decrease luciferase activity with significant difference among cell lines, showing destabilization in all lines with exception of HEK-293 for pGL4.71P-C1 and SK-N-BE and HEK-293 for pGL4.71P-C3. pGL4.71P-C6 decreases luciferase activity only in HEK-293 and MCF-7 cells (p < 0.01) and was not effective in neuroblastoma derived lines.
C1 Neg (exception) Binding (exception) of in MCF-7 associated with neuroblastoma
16) Confidence 0.02 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.09 Pain Relevance 0

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