INT46389

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Context Info
Confidence 0.23
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 8.29
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Anatomy Link Frequency
head 2
hepatocytes 1
cleavage 1
nucleus 1
neutrophils 1
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 29 99.54 Very High Very High Very High
intrathecal 4 99.40 Very High Very High Very High
Inflammation 220 97.68 Very High Very High Very High
Nicotine 1 95.64 Very High Very High Very High
alcohol 3 95.36 Very High Very High Very High
ischemia 56 90.40 High High
rheumatoid arthritis 301 89.20 High High
cytokine 48 88.04 High High
spinal inflammation 1 84.56 Quite High
Arthritis 45 82.88 Quite High
Disease Link Frequency Relevance Heat
Stress 16 99.72 Very High Very High Very High
Hypersensitivity 5 99.70 Very High Very High Very High
INFLAMMATION 254 99.36 Very High Very High Very High
Brain Injury 82 97.72 Very High Very High Very High
Injury 268 95.84 Very High Very High Very High
Hypoxia 3 95.56 Very High Very High Very High
Nicotine Addiction 2 95.28 Very High Very High Very High
Apoptosis 45 94.24 High High
Targeted Disruption 94 94.16 High High
Age-related Macular Degeneration 65 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, chronic ethanol consumption upregulates CFB but downregulates CFH in mice [87].
Positive_regulation (upregulates) of CFB
1) Confidence 0.23 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 1.34 Pain Relevance 0.19
Biotinylated citrullinated fibrinogen (CFb) was produced as previously reported [43] and tested for specificity using pooled sera from three ACPA+ and three ACPA?
Positive_regulation (citrullinated) of CFb
2) Confidence 0.17 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.09 Pain Relevance 0.04
CFb was then biotinylated using NHS-LC biotin (Pierce Biotechnology).
Positive_regulation (biotinylated) of CFb
3) Confidence 0.17 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.10 Pain Relevance 0.05
In clinical studies on TBI patients, we have reported elevated levels of the crucial components required for alternative pathway complement activation, factor B and C3, in the CSF of severely head-injured patients [37].
Positive_regulation (activation) of factor B in head associated with brain injury
4) Confidence 0.16 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.85 Pain Relevance 0.13
The observation of elevated factor B levels in the intrathecal compartment of severely head-injured patients further supports the pharmacological concept of a specific inhibition of factor B [49].
Positive_regulation (elevated) of factor B in head associated with intrathecal
5) Confidence 0.13 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 0.28 Pain Relevance 0.12
Transcriptional regulators of genes involved in the inflammatory response, for example, nuclear factor-kB (NF-kB) are activated by ER stress [134].
Positive_regulation (activated) of factor-kB associated with stress and inflammatory response
6) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.77 Pain Relevance 0.30
The chemotactic effects of C5a-C5aR ligation then attracts neutrophils to sites of inflammation to produce properdin, which, upon binding to C3b-IgG complexes, enhances the association with factor B, leading to stabilization of the alternative pathway C3 convertase and amplification of the alternative pathway C3 consumption.
Positive_regulation (stabilization) of convertase in neutrophils associated with inflammation
7) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175042 Disease Relevance 0.70 Pain Relevance 0.26
As shown with human C4bp the mouse C4bp binds both mouse C4b in vivo and in vitro [25,27], and mouse C4 is unable to form a functional C3 convertase when bound to C4bp [27].
Neg (unable) Positive_regulation (functional) of convertase
8) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.52 Pain Relevance 0
Functionally, C4bp limits complement activation by blocking the formation of and promoting the decay of the classical pathway C3 convertase.
Positive_regulation (promoting) of convertase
9) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.54 Pain Relevance 0.08
The effect of IxAC proteins may therefore be explained by a decreased stability of C3 convertase due to blocking of properdin.
Positive_regulation (stability) of convertase
10) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.09 Pain Relevance 0
We investigated the effect of I. ricinus IxAC proteins on the cleavage of factor B and on the production of C3a in the AP assay.
Positive_regulation (cleavage) of factor B in cleavage
11) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.22 Pain Relevance 0.05
Approximately 10 times less bound Bb was detected in the absence of properdin than in its presence (Figure 8A).
Positive_regulation (absence) of properdin
12) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
On the other hand, the half-life of C3 convertase is increased at least 10-fold by properdin [11].
Positive_regulation (increased) of convertase
13) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Components of C3 convertase (i.e.
Positive_regulation (Components) of convertase
14) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Enzyme-linked Immunosorbent assay for measuring the binding of recombinant IxAC to components of C3 convertase
Positive_regulation (components) of convertase
15) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Deposition of C3b and fB on agarose-coated microplates was used to measure AP activation and C3 convertase formation.
Positive_regulation (activation) of convertase
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
We also studied the effect of I. ricinus IxACs on the formation and stability of the alternative pathway C3 convertase (C3bBbP).
Positive_regulation (stability) of convertase
17) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
Positive_regulation (activation) of and B
18) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2940888 Disease Relevance 0.14 Pain Relevance 0
These patients also have accelerated delayed hypersensitivity responses and increased levels of factor B, C3 and C5 but normal levels of immunoglobulin and other complement components.
Positive_regulation (increased) of factor B associated with hypersensitivity
19) Confidence 0.02 Published 1982 Journal J Clin Lab Immunol Section Abstract Doc Link 6978407 Disease Relevance 0.86 Pain Relevance 0.21
The activation of this pathway has been linked to the activation and nuclear translocation of nuclear factor-kB (NFkB), which once in the nucleus, can lead to the up-regulation of neuroprotective genes (e.g., the caspase inhibitors: X-linked inhibitor of apoptosis proteins, XIAP, and cellular inhibitor of apoptosis proteins-2, c-IAP2) [32].
Positive_regulation (activation) of factor-kB in nucleus associated with apoptosis
20) Confidence 0.02 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.72 Pain Relevance 0.07

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