INT46392

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.23
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
plasma 1
liver 1
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 93.32 High High
rheumatoid arthritis 1 91.36 High High
Arthritis 1 88.60 High High
spinal inflammation 1 87.44 High High
Potency 23 79.44 Quite High
headache 5 76.16 Quite High
Inflammatory response 1 75.60 Quite High
Pain 2 69.56 Quite High
spinal stenosis 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 4 97.08 Very High Very High Very High
Emphysema 5 95.28 Very High Very High Very High
INFLAMMATION 4 93.32 High High
Rheumatoid Arthritis 1 91.36 High High
Systemic Lupus Erythematosus 1 90.48 High High
Juvenile Chronic Polyarthritis 1 89.28 High High
Uveitis 1 88.16 High High
Low Back Pain 1 87.44 High High
Pulmonary Fibrosis 1 86.48 High High
Migraine Disorders 1 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Background materials supporting this case history include: a model for AAT function, genetics of AAT deficiency, pathophysiology of both liver and pulmonary diseases, and a summary of treatment options and prognosis for AAT deficient patients.
Regulation (model) of AAT in liver associated with pulmonary disease
1) Confidence 0.44 Published 2001 Journal Clin Lab Sci Section Abstract Doc Link 11760819 Disease Relevance 0.78 Pain Relevance 0.22
The exercise did not appear to significantly affect serum levels of alpha-1-antitrypsin and alpha-1-acid glycoprotein.
Regulation (affect) of alpha-1-antitrypsin
2) Confidence 0.31 Published 1995 Journal Eur J Appl Physiol Occup Physiol Section Abstract Doc Link 7588680 Disease Relevance 0.54 Pain Relevance 0.14
Other pharmacokinetic parameters determined for alpha1-PI included first observed peak plasma alpha1-PI concentration following drug infusion (Cmax), time to reach observed Cmax (tmax), terminal half-life (t1/2), observed plasma alpha1-PI trough concentration prior to the start of infusions (Ctrough), and average trough concentration of alpha1-PI at steady state (mean Ctrough).
Regulation (concentration) of alpha1-PI in plasma
3) Confidence 0.24 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2958874 Disease Relevance 0.07 Pain Relevance 0.10
Immunoregulation by alpha 1 antitrypsin.
Regulation (Immunoregulation) of antitrypsin
4) Confidence 0.01 Published 1982 Journal J Clin Lab Immunol Section Title Doc Link 6978407 Disease Relevance 0.85 Pain Relevance 0.22

General Comments

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