INT46409

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Context Info
Confidence 0.29
First Reported 1982
Last Reported 1982
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 4.76
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (NDUFA5) mitochondrion (NDUFA5) small molecule metabolic process (NDUFA5)
Anatomy Link Frequency
anterior 1
skin 1
NDUFA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 9 99.72 Very High Very High Very High
spondylitis 2 98.58 Very High Very High Very High
spinal inflammation 10 83.52 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 9 99.72 Very High Very High Very High
Genetic Predisposition To Disease 2 99.26 Very High Very High Very High
Syndrome 11 99.22 Very High Very High Very High
Seronegative Spondarthritis 25 98.58 Very High Very High Very High
Uveitis 6 96.16 Very High Very High Very High
Disease 2 83.04 Quite High
Arthropathy 3 77.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on these findings and previous reports, we conclude that (i) AAU is a manifestation of Bechterew's syndrome in HLA B27 positive patients, (ii) HLA B27 negative patients without any obvious accompanying manifestations may suffer from psoriatic spondylitis, and (iii) genetic predisposition to psoriasis in persons who are HLA B13, B17 and B37 negative, may interact with the genetic predisposition to Bechterew's syndrome in HLA B27 positive persons and produce Bechterew's syndrome with psoriasis or psoriasis-like skin eruptions.
Neg (negative) Gene_expression (negative) of B13 in skin associated with seronegative spondarthritis, psoriasis, spondylitis, syndrome, genetic predisposition to disease and uveitis
1) Confidence 0.29 Published 1982 Journal Clin. Genet. Section Abstract Doc Link 6980067 Disease Relevance 2.54 Pain Relevance 0.68
When these new findings are added to the previous observations that acute anterior uveitis probably is a clinical, sex-influenced characteristic of HLA B27 positive Bechterew's syndrome, that HLA B27 negative patients with Bechterew's syndrome frequently had psoriasis and were HLA B13 and B17 negative, and that psoriasis was frequent in HLA B27 positive patients as well, we tentatively conclude that different and interacting genetic mechanisms may be involved in the etiology of Bechterew's syndrome.
Neg (negative) Gene_expression (negative) of B13 in anterior associated with seronegative spondarthritis, psoriasis, syndrome and uveitis
2) Confidence 0.29 Published 1982 Journal Clin. Genet. Section Abstract Doc Link 6983935 Disease Relevance 2.22 Pain Relevance 0.50

General Comments

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