INT4643

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.01
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GHR) extracellular space (GHR) extracellular region (GHR)
plasma membrane (GHR) nucleus (GHR) cytoplasm (GHR)
Anatomy Link Frequency
plasma 1
liver 1
internal 1
GHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 13 100.00 Very High Very High Very High
Clonidine 9 98.88 Very High Very High Very High
transdermal 2 98.68 Very High Very High Very High
cytokine 9 91.44 High High
Inflammation 55 86.36 High High
Morphine 4 82.44 Quite High
fibrosis 5 81.36 Quite High
Inflammatory response 4 77.08 Quite High
headache 7 54.40 Quite High
Potency 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 84 99.84 Very High Very High Very High
Hypertension 1 98.00 Very High Very High Very High
Apoptosis 11 97.48 Very High Very High Very High
Spinal Cord Injury 62 97.20 Very High Very High Very High
Death 11 96.72 Very High Very High Very High
Renal Disease 12 95.60 Very High Very High Very High
Toxicity 181 91.24 High High
INFLAMMATION 60 86.36 High High
Fibrosis 5 81.36 Quite High
Renal Failure 2 80.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In healthy individuals, the kidney accounts for about 50% of the total MCR,23 and it is less than this in patients with renal disease,24 whereas extrarenal elimination (mostly via the liver) does not seem to differ significantly between the two groups.23 However, the situation is made more complex by the fact that GH also exists (reversibly) bound to GHBP, which is decreased in ESRD patients; the relative amounts of bound GH will most likely also correlate with the GH elimination rate.
Negative_regulation (decreased) of GHBP in liver associated with chronic renal failure and renal disease
1) Confidence 0.45 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.52 Pain Relevance 0.05
Down-regulation of GHR implies that growth and proliferation are inhibited, and that apoptosis and cell death are prevalent.
Negative_regulation (regulation) of GHR associated with apoptosis and death
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.81 Pain Relevance 0.28
IGFBP-I was also significantly greater in ESRD patients at baseline, as has been previously reported,13 whereas baseline GHBP was significantly reduced.
Negative_regulation (reduced) of GHBP associated with chronic renal failure
3) Confidence 0.40 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.55 Pain Relevance 0
Profound growth failure despite elevated GH levels in GH receptor deficiency (GHRD) results from reduced insulin-like growth factor-I (IGF-I) synthesis.
Negative_regulation (deficiency) of GH receptor deficiency
4) Confidence 0.30 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7686916 Disease Relevance 0.14 Pain Relevance 0
Injected animals in He-O2 at 1 ATA showed no changes from those in ambient air, but animals injected and exposed to 11 ATA did not have a decreased serum protein level or an increase in potassium.
Negative_regulation (decreased) of serum protein
5) Confidence 0.27 Published 1976 Journal Aviat Space Environ Med Section Abstract Doc Link 1252207 Disease Relevance 0 Pain Relevance 0.30
binding protein (GHBP) to binding site 1, was estimated to reveal
Negative_regulation (reveal) of GHBP
6) Confidence 0.07 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.20 Pain Relevance 0
After processing, we estimate each sample contained a mixture of approximately 1 mg of internal standard and 1 mg of depleted serum protein.


Negative_regulation (depleted) of serum protein in internal
7) Confidence 0.03 Published 2009 Journal Journal of Proteome Research Section Body Doc Link PMC2652408 Disease Relevance 0.31 Pain Relevance 0
In eight hypertensive patients treated with transdermal clonidine for one year, there was plasma dilution, as shown by a reduction in serum sodium, hemoglobin, and serum protein levels.
Negative_regulation (reduction) of serum protein in plasma associated with transdermal, hypertension and clonidine
8) Confidence 0.03 Published 1989 Journal Int J Artif Organs Section Abstract Doc Link 2744881 Disease Relevance 0.10 Pain Relevance 0.35
The test drug is exposed to the cell system in the presence of decreasing amounts of serum protein (Fig. 13).
Negative_regulation (decreasing) of serum protein
9) Confidence 0.02 Published 2010 Journal Combinatorial Chemistry & High Throughput Screening Section Body Doc Link PMC2908937 Disease Relevance 0.30 Pain Relevance 0
Total serum protein level (g/100ml) significantly increased following caffeination as well as during co-administration of caffeinated paracetamol and Vitamin E; and significantly decreased during co-administration of paracetamol and vitamin A.
Negative_regulation (decreased) of serum protein associated with paracetamol
10) Confidence 0.00 Published 2007 Journal Niger J Physiol Sci Section Abstract Doc Link 18379621 Disease Relevance 0.07 Pain Relevance 1.03

General Comments

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