INT46453

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Context Info
Confidence 0.03
First Reported 1980
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.65
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Pprc1) nucleus (Pprc1)
Anatomy Link Frequency
blood 1
neurons 1
kidney 1
Pprc1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 96.64 Very High Very High Very High
withdrawal 5 95.28 Very High Very High Very High
narcan 2 94.32 High High
Morphine 5 93.48 High High
Nucleus accumbens 2 92.84 High High
Locus ceruleus 1 90.52 High High
Ventral tegmentum 1 89.72 High High
Hippocampus 1 88.76 High High
addiction 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1 91.92 High High
Stress 1 86.72 High High
Hypertension 4 83.52 Quite High
Targeted Disruption 2 75.28 Quite High
Breast Cancer 7 48.12 Quite Low
Prostate Cancer 20 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Ovarian Cancer 2 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no significant correlation between the age-related changes in PRC and those in renal blood flow or its intrarenal distribution.
Regulation (changes) of PRC in blood
1) Confidence 0.03 Published 1980 Journal Pediatr. Res. Section Abstract Doc Link 6990367 Disease Relevance 0 Pain Relevance 0.09
Ether had no effect on PRC in TGR(mREN2)27.
Neg (no) Regulation (effect) of PRC
2) Confidence 0.02 Published 1996 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 8886477 Disease Relevance 0.65 Pain Relevance 0.10
Our results indicate that the expression levels of aldolase C and PRC8 proteins were altered in a time- and region-specific manner, and suggest that they could be implicated in the molecular changes underlying adaptations of neurons observed with chronic morphine treatment.
Regulation (altered) of PRC8 in neurons associated with morphine
3) Confidence 0.01 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345208 Disease Relevance 0 Pain Relevance 0.72
MAK (Male Germ Cell-Associated Kinase) is a recently identified AR coactivator [30] that initially has been found to be strongly androgen-regulated in mice kidney [31].
Regulation (regulated) of coactivator in kidney
4) Confidence 0.00 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2518564 Disease Relevance 0 Pain Relevance 0

General Comments

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