INT46460

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Context Info
Confidence 0.78
First Reported 1980
Last Reported 2010
Negated 6
Speculated 20
Reported most in Abstract
Documents 288
Total Number 339
Disease Relevance 135.51
Pain Relevance 305.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
neurons 23
peripheral nervous system 20
muscle 17
dorsal root ganglion 16
sperm 14
NAV1 (Homo sapiens)
NAV1 - V1298F (1) NAV1 - I693T (1)
Pain Link Frequency Relevance Heat
sodium channel 8062 100.00 Very High Very High Very High
Nav1.7 5736 100.00 Very High Very High Very High
tetrodotoxin 3045 100.00 Very High Very High Very High
nav1.8 1280 100.00 Very High Very High Very High
Paroxysmal extreme pain disorder 825 100.00 Very High Very High Very High
Nav1.9 719 100.00 Very High Very High Very High
Nav1.1 712 100.00 Very High Very High Very High
nav1.3 388 100.00 Very High Very High Very High
Nav1.2 365 100.00 Very High Very High Very High
Nav1.6 355 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1141 100.00 Very High Very High Very High
Erythermalgia 1052 100.00 Very High Very High Very High
Somatoform Disorder 864 100.00 Very High Very High Very High
Reprotox - General 1 253 100.00 Very High Very High Very High
Congenital Pain Insensitivity 35 99.92 Very High Very High Very High
Pulpitis 406 99.84 Very High Very High Very High
Nociception 249 99.84 Very High Very High Very High
Neuroblastoma 105 99.76 Very High Very High Very High
Headache 49 99.76 Very High Very High Very High
Injury 156 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results demonstrate the expression of Nav1.5 in human astrocytes and show that Nav1.5 expression is dynamic in these cells.
Gene_expression (expression) of Nav1 in astrocytes
1) Confidence 0.78 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.57 Pain Relevance 0.89
These results demonstrate the expression of Nav1.5 in human astrocytes and show that Nav1.5 expression is dynamic in these cells.
Gene_expression (expression) of Nav1 in astrocytes
2) Confidence 0.78 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.58 Pain Relevance 0.91
Nav1.5 was also expressed at high levels in astrocytes in tissue surrounding new and old cerebrovascular accidents and brain tumours.
Gene_expression (expressed) of Nav1 in astrocytes associated with stroke and brain tumor
3) Confidence 0.78 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.60 Pain Relevance 0.98
Our observations suggest that the upregulated expression of Nav1.5 in astrocytes may provide a compensatory mechanism, which supports sodium/potassium pump-dependent ionic homoeostasis in areas of central nervous system injury.
Gene_expression (expression) of Nav1 in central nervous system associated with nervous system injury and central nervous system
4) Confidence 0.78 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.59 Pain Relevance 0.84
Nav1.9 channels were expressed in membranes and cytoplasm of human trigeminal ganglion neurons, with the highest expression in small neuronal somata.
Gene_expression (expressed) of Nav1 in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion neurons and nav1.9
5) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17889684 Disease Relevance 0.52 Pain Relevance 1.63
Expression of Nav1.9 channels in human dental pulp and trigeminal ganglion.
Gene_expression (Expression) of Nav1 in dental pulp associated with ganglion cysts, trigeminal ganglion, neuropeptide and nav1.9
6) Confidence 0.78 Published 2007 Journal J Endod Section Title Doc Link 17889684 Disease Relevance 0.46 Pain Relevance 1.57
Immunocytochemistry was used to examine Nav1.9 channel expression in axons of symptomatic (painful) versus asymptomatic human dental pulp and to determine Nav1.9 expression levels in neuronal somata of the human trigeminal ganglion.
Spec (determine) Gene_expression (expression) of Nav1 in dental pulp associated with ganglion cysts, pain, trigeminal ganglion and nav1.9
7) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17889684 Disease Relevance 0.48 Pain Relevance 1.62
Nav1.9 expression in the trigeminal ganglion coupled with increased expression in symptomatic pulp might contribute to hypersensitivity of inflamed pulps and local anesthetic failure.
Gene_expression (expression) of Nav1 in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion, hypersensitivity, local anesthetic and nav1.9
8) Confidence 0.78 Published 2007 Journal J Endod Section Abstract Doc Link 17889684 Disease Relevance 0.53 Pain Relevance 1.59
Our results have shown increased expression of the Nav1.3 sodium channel in the spinal cord and thalamus.
Gene_expression (expression) of Nav1 in thalamus associated with nav1.3, sodium channel, thalamus and spinal cord
9) Confidence 0.78 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17618978 Disease Relevance 0.75 Pain Relevance 1.21
This review provides an overview of the NaV1 channel subtypes that are preferentially expressed in nociceptive neurons, the assay technologies used to develop NaV1 channel blockers, and a summary of recent advances in the development of subtype-selective and novel state-dependent NaV1 channel blockers.
Gene_expression (expressed) of NaV1 in neurons associated with nociception
10) Confidence 0.78 Published 2009 Journal Curr Opin Drug Discov Devel Section Abstract Doc Link 19736626 Disease Relevance 0.54 Pain Relevance 0.90
This channel is co-expressed with Nav1.8, which sustains the initial action potential; Nav1.3 is an embrionary channel which is expressed in neurons after injury, as in neuropathic conditions.
Gene_expression (co-expressed) of Nav1 in neurons associated with nav1.3, action potential, neuropathic pain, injury and nav1.8
11) Confidence 0.78 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.08 Pain Relevance 1.73
Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.
Gene_expression (expression) of Nav1 associated with pain, nav1.3, trigeminal neuralgia, sodium channel, nav1.8 and nav1.7
12) Confidence 0.78 Published 2009 Journal Neuroscience Section Title Doc Link 19699781 Disease Relevance 1.07 Pain Relevance 2.15
The aim of this study was to investigate the expression of Nav1.3, Nav1.7 and Nav1.8 by RT-PCR in patients with TN, compared to controls.
Spec (investigate) Gene_expression (expression) of Nav1 associated with nav1.3, trigeminal neuralgia, nav1.8 and nav1.7
13) Confidence 0.78 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.14 Pain Relevance 2.06
The aim of this study was to investigate the expression of Nav1.3, Nav1.7 and Nav1.8 by RT-PCR in patients with TN, compared to controls.
Spec (investigate) Gene_expression (expression) of Nav1 associated with nav1.3, trigeminal neuralgia, nav1.8 and nav1.7
14) Confidence 0.78 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.14 Pain Relevance 2.06
The aim of this study was to investigate the expression of Nav1.3, Nav1.7 and Nav1.8 by RT-PCR in patients with TN, compared to controls.
Spec (investigate) Gene_expression (expression) of Nav1 associated with nav1.3, trigeminal neuralgia, nav1.8 and nav1.7
15) Confidence 0.78 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.14 Pain Relevance 2.06
Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.
Gene_expression (expression) of Nav1 associated with pain, nav1.3, trigeminal neuralgia, sodium channel, nav1.8 and nav1.7
16) Confidence 0.78 Published 2009 Journal Neuroscience Section Title Doc Link 19699781 Disease Relevance 1.08 Pain Relevance 2.17
Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.
Gene_expression (expression) of Nav1 associated with pain, nav1.3, trigeminal neuralgia, sodium channel, nav1.8 and nav1.7
17) Confidence 0.78 Published 2009 Journal Neuroscience Section Title Doc Link 19699781 Disease Relevance 1.07 Pain Relevance 2.16
This channel is co-expressed with Nav1.8, which sustains the initial action potential; Nav1.3 is an embrionary channel which is expressed in neurons after injury, as in neuropathic conditions.
Gene_expression (expressed) of Nav1 in neurons associated with nav1.3, action potential, neuropathic pain, injury and nav1.8
18) Confidence 0.78 Published 2009 Journal Neuroscience Section Abstract Doc Link 19699781 Disease Relevance 1.12 Pain Relevance 1.86
Nav1.9 was expressed in trigeminal ganglion neuronal somata (small and medium sized), and also along trigeminal afferent fibres and the terminal branches within lip skin and dental pulp.
Gene_expression (expressed) of Nav1 in neuronal associated with ganglion cysts, trigeminal ganglion and nav1.9
19) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 0.60 Pain Relevance 1.60
It is unlikely that extracting teeth, or taking tongue biopsies, under local or general anaesthesia will affect Nav channel expression; the acute effects of anaesthetics would not be expected to alter Nav channel levels in the short term, as Nav channels are synthesized in cell bodies and axonally transport to the nerve terminals where they are inserted into membranes, a process with a turnover of several days.
Gene_expression (expression) of Nav in teeth
20) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 0.57 Pain Relevance 0.97

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