INT4647

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2010
Negated 4
Speculated 4
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 5.28
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hbb)
Anatomy Link Frequency
blood 6
erythrocytes 1
heart 1
Hbb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 14 100.00 Very High Very High Very High
cva 41 99.36 Very High Very High Very High
imagery 33 97.64 Very High Very High Very High
halothane 9 96.72 Very High Very High Very High
antidepressant 16 96.32 Very High Very High Very High
Inflammation 20 95.76 Very High Very High Very High
Analgesic 1 95.72 Very High Very High Very High
fluoxetine 1 94.56 High High
depression 48 93.84 High High
ischemia 36 86.84 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 41 99.36 Very High Very High Very High
Anaemia 49 99.18 Very High Very High Very High
Diabetes Mellitus 123 98.78 Very High Very High Very High
Chronic Renal Failure 62 98.40 Very High Very High Very High
INFLAMMATION 18 95.76 Very High Very High Very High
Infection 8 94.64 High High
Depression 64 93.84 High High
Peripheral Arterial Disease 1 92.60 High High
Coronary Artery Disease 16 86.84 High High
Stress 18 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic administration of a small dose to the rat for 70 days had no effect on blood glucose, blood urea nitrogen, hemoglobin, or microhematocrit values.
Neg (no) Regulation (effect) of hemoglobin in blood
1) Confidence 0.60 Published 1976 Journal J Pharm Sci Section Abstract Doc Link 1255412 Disease Relevance 0.07 Pain Relevance 0.10
Changes in hemoglobin oxygenation and concentration were measured using optical imaging spectroscopy, and cerebral blood flow changes were measured using laser Doppler flowmetry.
Regulation (Changes) of hemoglobin in blood associated with imagery
2) Confidence 0.45 Published 2006 Journal Neuroimage Section Abstract Doc Link 16725349 Disease Relevance 0.09 Pain Relevance 0.17
The effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) and other hemoglobin-related substances on arterial blood pressure (ABP) and heart rate (HR) were examined.
Spec (examined) Regulation (effects) of hemoglobin in heart
3) Confidence 0.33 Published 1995 Journal Artif Organs Section Abstract Doc Link 7763190 Disease Relevance 0 Pain Relevance 0
Effects of pyridoxalated hemoglobin polyoxyethylene conjugate and other hemoglobin-related substances on arterial blood pressure in anesthetized and conscious rats.
Regulation (Effects) of hemoglobin in blood associated with anesthesia
4) Confidence 0.25 Published 1995 Journal Artif Organs Section Title Doc Link 7763190 Disease Relevance 0 Pain Relevance 0.10
However, the levels of albumin, total bilirubin, creatinine, the mean corpuscular volume, the mean corpuscular hemoglobin, and the mean corpuscular hemoglobin concentration were not statistically influenced.
Neg (not) Regulation (influenced) of hemoglobin
5) Confidence 0.12 Published 2003 Journal J Trace Elem Med Biol Section Abstract Doc Link 12755499 Disease Relevance 0.28 Pain Relevance 0.65
Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides, and cholesterol levels in blood of streptozotocin-treated diabetic rats.
Regulation (Effect) of hemoglobin in blood associated with diabetes mellitus
6) Confidence 0.07 Published 2007 Journal Free Radic. Biol. Med. Section Title Doc Link 17854708 Disease Relevance 0.33 Pain Relevance 0.10
This study examined the effect of chromium niacinate (Cr-N) or chromium picolinate (Cr-P) supplementation on lipid peroxidation (LP), TNF-alpha, IL-6, C-reactive protein (CRP), glycosylated hemoglobin (HbA(1)), cholesterol, and triglycerides (TG) in diabetic rats.
Spec (examined) Regulation (effect) of hemoglobin associated with diabetes mellitus
7) Confidence 0.05 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17854708 Disease Relevance 0.34 Pain Relevance 0.08
Effect on Glycosylated Hemoglobin
Regulation (Effect) of Hemoglobin
8) Confidence 0.05 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2907017 Disease Relevance 0.33 Pain Relevance 0
The equation for rCMRO2 was derived based on direct measurements of changes in CBF, deoxyhemoglobin and total hemoglobin in the venous compartment.
Regulation (changes) of hemoglobin
9) Confidence 0.04 Published 2010 Journal Frontiers in Neuroenergetics Section Body Doc Link PMC2922941 Disease Relevance 0.07 Pain Relevance 0.03
In a study with sertraline, glycosylated hemoglobin (HbA1c) levels were reduced during treatment, but did not differ between the sertraline and placebo groups,15,16 whereas no significant reduction in HbA1c levels was observed in patients treated with fluoxetine or paroxetine, although their depressive symptoms were significantly improved.17 Similarly, although escitalopram resulted in a significant reduction of depression score, there was only a small and nonsignificant reduction in fasting blood glucose (FBG) levels and HbA1c levels.18 It would thus appear that selective serotonin reuptake inhibitors (SSRIs) do not have any major effect on metabolic control, even when they produce a significant effect on depressive symptoms.
Neg (not) Regulation (differ) of hemoglobin in blood associated with depression, ssri and fluoxetine
10) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2819761 Disease Relevance 1.91 Pain Relevance 0.72
Although hemoglobin levels of erythrocytes were not affected, methemoglobin concentration was significantly increased in hypercholesterolemic rats.
Neg (not) Regulation (affected) of hemoglobin in erythrocytes
11) Confidence 0.02 Published 2004 Journal Int J Vitam Nutr Res Section Abstract Doc Link 15296079 Disease Relevance 0 Pain Relevance 0.21
The goals of this study were to determine the effects of recombinant human hemoglobin (rHb1.1, 1 g/kg i.v.) on systemic hemodynamics, regional blood flows, and regional vascular resistances in rats.
Spec (determine) Regulation (effects) of hemoglobin in blood
12) Confidence 0.02 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9436806 Disease Relevance 0 Pain Relevance 0.12
In addition to its antianginal action in diabetic patients with chronic angina, ranolazine may have favorable effects on glycated hemoglobin levels.



Spec (may) Regulation (effects) of hemoglobin associated with diabetes mellitus and cva
13) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2597754 Disease Relevance 0.85 Pain Relevance 0.29
The integration of ESA and intravenous iron therapy into anemia management allowed attainment of target hemoglobin values in the majority of pediatric and adult CKD and ESRD patients.



Regulation (values) of hemoglobin associated with chronic renal failure and anaemia
14) Confidence 0.01 Published 2007 Journal Pediatr Nephrol Section Abstract Doc Link PMC1805051 Disease Relevance 1.01 Pain Relevance 0.09

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