INT46518

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Context Info
Confidence 0.65
First Reported 1980
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.31
Pain Relevance 6.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mtr) intracellular (Mtr) cytoplasm (Mtr)
Anatomy Link Frequency
corpus striatum 3
ileum 2
SPN 1
brain 1
nucleus 1
Mtr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 61 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 100.00 Very High Very High Very High
narcan 14 99.56 Very High Very High Very High
Morphine 6 99.30 Very High Very High Very High
Endogenous opioid 7 96.32 Very High Very High Very High
Neuropeptide 7 95.98 Very High Very High Very High
Neuritis 4 95.56 Very High Very High Very High
Hippocampus 1 89.36 High High
Multiple sclerosis 3 84.92 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 98.20 Very High Very High Very High
Optic Neuritis 4 95.80 Very High Very High Very High
Demyelinating Disease 4 84.92 Quite High
Congenital Anomalies 3 80.32 Quite High
Depression 2 73.80 Quite High
Headache 4 56.64 Quite High
Increased Venous Pressure Under Development 1 55.68 Quite High
Ganglion Cysts 2 52.52 Quite High
Syndrome 1 45.20 Quite Low
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intrinsic MTR decrease seen in patients suggests that there are structural changes in the visual cortex following an attack of optic neuritis.
Localization (decrease) of MTR in optic associated with optic neuritis and neuritis
1) Confidence 0.65 Published 2006 Journal Brain Section Abstract Doc Link 16495327 Disease Relevance 0.60 Pain Relevance 0.44
Methionine-enkephalin, as measured by radioimmunoassay, was shown to be released from tissues maintained at an intraluminal pressure of O cm water (resting conditions).
Localization (released) of Methionine-enkephalin associated with enkephalin
2) Confidence 0.64 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7227458 Disease Relevance 0 Pain Relevance 0.44
Peristalsis abolishes the release of methionine-enkephalin from guinea-pig ileum in vitro.
Localization (release) of methionine-enkephalin in ileum associated with enkephalin
3) Confidence 0.56 Published 1981 Journal Eur. J. Pharmacol. Section Title Doc Link 7227458 Disease Relevance 0 Pain Relevance 0.61
The release of methionine-enkephalin from superfused guinea-pig ileum has been demonstrated.
Localization (release) of methionine-enkephalin in ileum associated with enkephalin
4) Confidence 0.56 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7227458 Disease Relevance 0 Pain Relevance 0.41
Increased intraluminal pressure (5 cm water) induced peristalsis and abolished the release of methionine-enkephalin.
Localization (release) of methionine-enkephalin associated with enkephalin
5) Confidence 0.49 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7227458 Disease Relevance 0 Pain Relevance 0.45
Effects of morphine and naloxone on the K+-stimulated release of methionine-enkephalin from slices of rat corpus striatum.
Localization (release) of methionine-enkephalin in corpus striatum associated with narcan, enkephalin and morphine
6) Confidence 0.13 Published 1980 Journal Brain Res. Section Title Doc Link 7370786 Disease Relevance 0.07 Pain Relevance 1.41
Methionine-enkephalin (ME) released from superfused slices of rat corpus striatum was estimated by radioimmunoassay (RIA).
Localization (released) of Methionine-enkephalin in corpus striatum associated with enkephalin
7) Confidence 0.13 Published 1980 Journal Brain Res. Section Abstract Doc Link 7370786 Disease Relevance 0.05 Pain Relevance 0.71
Methionine enkephalin release was evoked by depolarization of slices from rat striatum with potassium.
Localization (release) of Methionine enkephalin in striatum associated with enkephalin
8) Confidence 0.09 Published 1981 Journal Science Section Abstract Doc Link 7015510 Disease Relevance 0 Pain Relevance 0.32
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Localization (released) of methionine enkephalin in brain associated with enkephalin
9) Confidence 0.08 Published 1981 Journal Science Section Title Doc Link 7015510 Disease Relevance 0 Pain Relevance 0.70
Inhibition of other known enkephalin-hydrolyzing enzymes--aminopeptidase by 0.1 mM puromycin or angiotensin-converting enzyme by 1 microM captopril--did not significantly enhance the recovery of released methionine enkephalin.
Localization (released) of methionine enkephalin associated with enkephalin
10) Confidence 0.08 Published 1981 Journal Science Section Abstract Doc Link 7015510 Disease Relevance 0 Pain Relevance 0.52
The decrease of the immunoreactivity in the ipsilateral side (stimulated) suggests that methionine enkephalin, neurotensin and somatostatin 28 are released in the caudal trigeminal nucleus after electrical stimulation of the trigeminal ganglion; 2.
Localization (released) of methionine enkephalin in nucleus
11) Confidence 0.08 Published 2002 Journal Rev Neurol Section Body Doc Link 12080490 Disease Relevance 0.16 Pain Relevance 0
To explore coexpression of ChAT and neuropeptides in somata and axon processes of SPN, we investigated, using immunohistochemistry, retrograde labeling, confocal analysis, and tridimensional reconstruction, whether ChAT and the peptides neurotensin, methionine-ENK, somatostatin, calcitonin gene-related peptide, and vasoactive intestinal peptide colocalize in somata, axons fibers, and boutons of cat SPN.
Localization (colocalize) of methionine-ENK in SPN associated with somatostatin, neuropeptide, urological neuroanatomy, enkephalin and calcitonin gene-related peptide
12) Confidence 0.00 Published 2006 Journal Synapse Section Abstract Doc Link 16786529 Disease Relevance 0.42 Pain Relevance 0.54

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