INT4652

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Context Info
Confidence 0.32
First Reported 1976
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 7.41
Pain Relevance 5.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 5
chondrocytes 1
NAc 1
projection neurons 1
neurons 1
CB (Mus musculus)
Pain Link Frequency Relevance Heat
cva 7 100.00 Very High Very High Very High
depression 3 100.00 Very High Very High Very High
Adelta 1 100.00 Very High Very High Very High
Spinal cord 5 99.90 Very High Very High Very High
Nucleus accumbens 5 99.68 Very High Very High Very High
Fibrositis 2 99.56 Very High Very High Very High
Pyramidal cell 160 99.50 Very High Very High Very High
Nerve growth factor 9 98.72 Very High Very High Very High
Myofascial pain syndrome 2 98.08 Very High Very High Very High
Thalamus 78 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 51 100.00 Very High Very High Very High
Cv General 3 Under Development 7 100.00 Very High Very High Very High
Depression 3 100.00 Very High Very High Very High
Sleep Disorders 4 99.56 Very High Very High Very High
Tauopathy 120 99.28 Very High Very High Very High
Increased Venous Pressure Under Development 5 99.12 Very High Very High Very High
Pressure And Volume Under Development 6 98.68 Very High Very High Very High
Systemic Lupus Erythematosus 2 98.56 Very High Very High Very High
Myofascial Pain Syndromes 2 98.08 Very High Very High Very High
Hyperalgesia 2 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GEO data mining revealed that fibroblasts, myofibroblasts, chondrocytes and synoviocytes expressed CB(1), CB(2) and eCB ligand-metabolizing enzymes.
Gene_expression (expressed) of eCB in chondrocytes
1) Confidence 0.32 Published 2008 Journal J Bodyw Mov Ther Section Abstract Doc Link 19083670 Disease Relevance 0.76 Pain Relevance 0.58
However, expression of the eCB system in myofascial tissues has not been established.
Gene_expression (expression) of eCB
2) Confidence 0.28 Published 2008 Journal J Bodyw Mov Ther Section Abstract Doc Link 19083670 Disease Relevance 0.50 Pain Relevance 0.50
In the absence of CB, fMet-Leu-Phe and PAF were much less effective.
Neg (absence) Gene_expression (absence) of CB
3) Confidence 0.02 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2552328 Disease Relevance 0 Pain Relevance 0.85
We evaluated on lumbar spinal cord the expression of microglial (ED-1), astrocytic (GFAP and S-100beta), and C- and Adelta-fibers (SubP, IB-4 and Cb) markers.
Gene_expression (expression) of Cb in spinal cord associated with adelta and spinal cord
4) Confidence 0.02 Published 2010 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 19585233 Disease Relevance 0.88 Pain Relevance 1.00
Thalamic nuclei in primates have two major neurochemical classes of projection neurons, distinguished by their expression of the calcium binding protein parvalbumin (PV) or calbindin (CB) [18], [19].
Gene_expression (expression) of CB in projection neurons associated with pyramidal cell
5) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1952177 Disease Relevance 0 Pain Relevance 0.05
CB and PV are expressed in distinct classes of projection neurons in the thalamus and distinct neurochemical classes of inhibitory neurons in the cortex.
Gene_expression (expressed) of CB in neurons associated with pyramidal cell and thalamus
6) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1952177 Disease Relevance 0 Pain Relevance 0.21
Nevertheless, the time-scale of spreading was very slow and resulted in typical tauopathy with aggregates and tangles, while neuro-degeneration was minimal or absent [44].
Neg (absent) Gene_expression (absent) of neuro-degeneration associated with tauopathy
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 1.12 Pain Relevance 0.04
A final important point concerns the question why AAV-based models are more powerful in producing neuro-degeneration than transgenic models expressing the same wild-type Tau4R isoform [41] or Tau.P301L mutant [23] at similar near-physiological levels.
Gene_expression (producing) of neuro-degeneration associated with targeted disruption
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 1.08 Pain Relevance 0.03
A final important point concerns the question why AAV-based models are more powerful in producing neuro-degeneration than transgenic models expressing the same wild-type Tau4R isoform [41] or Tau.P301L mutant [23] at similar near-physiological levels.
Gene_expression (expressing) of neuro-degeneration associated with targeted disruption
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 1.08 Pain Relevance 0.03
Fentanyl (25 and 100 micrograms/kg iv) produced dose dependent depression of cerebral blood flow (CBF), measured by radioactive microspheres, and cerebral oxygen consumption (CMRO2).
Gene_expression (produced) of cerebral blood flow in blood associated with depression
10) Confidence 0.00 Published 1985 Journal Life Sci. Section Abstract Doc Link 3999926 Disease Relevance 0.10 Pain Relevance 0.69
To address this issue, we explored the effect of drug self-administration on interstitial eCB levels in the nucleus accumbens (NAc) shell using in vivo microdialysis.
Gene_expression (levels) of eCB in NAc associated with nucleus accumbens
11) Confidence 0.00 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17409233 Disease Relevance 0 Pain Relevance 0.52
In this study, volumetric three-dimensional (3D) gradient and spin echo (GRASE) ASL was used to produce cerebral blood flow (CBF) and arterial arrival time (AAT) maps during rest and during an infusion of remifentanil.
Gene_expression (produce) of cerebral blood flow in blood associated with ultiva
12) Confidence 0.00 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 18506198 Disease Relevance 0 Pain Relevance 0.27
Alterations in behavior, brain electrical activity, cerebral blood flow, and intracranial pressure produced by triethyl tin sulfate induced cerebral edema.
Gene_expression (produced) of cerebral blood flow in blood associated with pressure and volume under development and cva
13) Confidence 0.00 Published 1976 Journal Stroke Section Title Doc Link 1258101 Disease Relevance 0.84 Pain Relevance 0.42
We studied the patterns of cerebral blood flow (CBF), over time, in patients with systemic lupus erythematosus and varying neurologic manifestations including headache, stroke, psychosis, and encephalopathy.
Gene_expression (patterns) of cerebral blood flow in blood associated with encephalopathy, psychosis, stroke, headache, systemic lupus erythematosus and neurologic manifestations
14) Confidence 0.00 Published 1990 Journal Neurology Section Abstract Doc Link 2296389 Disease Relevance 0.95 Pain Relevance 0.16
BACKGROUND: Recent work in animals suggests that nitric oxide may play a role in the cerebral blood flow (CBF) changes produced by anesthetics, particularly the vasodilation seen with volatile anesthetics.
Gene_expression (produced) of cerebral blood flow in blood associated with increased venous pressure under development
15) Confidence 0.00 Published 1994 Journal Anesthesiology Section Abstract Doc Link 7517107 Disease Relevance 0.10 Pain Relevance 0.22

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