INT46530

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 11.23
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pthlh) Golgi apparatus (Pthlh) nucleolus (Pthlh)
nucleus (Pthlh) intracellular (Pthlh) cellular_component (Pthlh)
Anatomy Link Frequency
parathyroid 6
macrophages 2
epithelial cells 2
neuronal 1
lung 1
Pthlh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 4 98.44 Very High Very High Very High
Pain 3 98.16 Very High Very High Very High
imagery 1 95.76 Very High Very High Very High
monoamine 1 95.28 Very High Very High Very High
opioid receptor 3 94.52 High High
Dopamine 1 94.40 High High
Serotonin 1 93.36 High High
agonist 2 89.84 High High
Thalamus 1 83.08 Quite High
Enkephalin 1 76.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 19 99.98 Very High Very High Very High
Bladder Cancer 3 99.98 Very High Very High Very High
Metastasis 8 99.62 Very High Very High Very High
Hypercalcemia 32 99.58 Very High Very High Very High
Congenital Anomalies 2 99.04 Very High Very High Very High
Malignant Neoplastic Disease 17 98.88 Very High Very High Very High
Osteoporosis 8 98.72 Very High Very High Very High
Low Back Pain 4 98.44 Very High Very High Very High
Renal Cancer 9 98.36 Very High Very High Very High
Paraneoplastic Syndromes 4 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although it is robustly expressed in fetal lung, PTHrP expression has not been assigned to alveolar epithelial cells in adult lung.
Gene_expression (expression) of PTHrP in lung
1) Confidence 0.78 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.19 Pain Relevance 0
Immunoassay of cell extracts demonstrated that freshly isolated type II cells contained PTHrP (136 pg/10(7) cells), whereas freshly isolated alveolar macrophages and cultured macrophages did not express PTHrP.
Neg (not) Gene_expression (express) of PTHrP in macrophages
2) Confidence 0.78 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.15 Pain Relevance 0.14
We have shown that PTHrP is expressed in the adult rat lung and by cultured rat alveolar type II epithelial cells with sensitive and specific immunoassays and immunohistochemical techniques.
Gene_expression (expressed) of PTHrP in epithelial cells
3) Confidence 0.78 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.18 Pain Relevance 0
Immunoassay of cell extracts demonstrated that freshly isolated type II cells contained PTHrP (136 pg/10(7) cells), whereas freshly isolated alveolar macrophages and cultured macrophages did not express PTHrP.
Gene_expression (contained) of PTHrP in macrophages
4) Confidence 0.68 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 7946399 Disease Relevance 0.16 Pain Relevance 0.12
Alveolar epithelial cells express and secrete parathyroid hormone-related protein.
Gene_expression (express) of hormone-related protein in epithelial cells
5) Confidence 0.53 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Title Doc Link 7946399 Disease Relevance 0.19 Pain Relevance 0.11
The back pain and biochemical abnormalities presented as hypercalcemia and elevated plasma levels of the parathyroid hormone-related protein (PTH-rP) that returned to normal indices with increasing BMD after weaning.
Gene_expression (levels) of PTH-rP in parathyroid associated with congenital anomalies, hypercalcemia and backache
6) Confidence 0.52 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.46 Pain Relevance 0.19
The back pain and biochemical abnormalities presented as hypercalcemia and elevated plasma levels of the parathyroid hormone-related protein (PTH-rP) that returned to normal indices with increasing BMD after weaning.
Gene_expression (levels) of parathyroid hormone-related protein in parathyroid associated with congenital anomalies, hypercalcemia and backache
7) Confidence 0.52 Published 1999 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 10067016 Disease Relevance 0.46 Pain Relevance 0.19
Malignancy-associated hypercalcemia (MAH) is caused by tumor over-production of parathyroid hormone-related protein (PTHrP), or by locally enhanced bone resorption in metastatic lesions of solid cancers.
Gene_expression (production) of parathyroid hormone-related protein in parathyroid associated with malignant neoplastic disease, cancer and hypercalcemia
8) Confidence 0.42 Published 2006 Journal Clin Calcium Section Abstract Doc Link 16582519 Disease Relevance 1.18 Pain Relevance 0.06
The patients with HHM who were administrated drugs such as bisphosphonate and calcitonin showed a reduction in their Ca and PTH-rP levels, and the six of ten EORTC QLQ-C30 subscales (emotional functioning, cognitive functioning, fatigue, dyspnoea, nausea/vomiting and appetite loss) were also improved after the anti-hypercalcemic therapy.
Gene_expression (levels) of PTH-rP associated with appetite loss, cognitive disorder, malignant neoplastic disease, vomiting, fatigue and dyspnea
9) Confidence 0.31 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 12729778 Disease Relevance 1.99 Pain Relevance 0.06
The patients with HHM who were administrated drugs such as bisphosphonate and calcitonin showed a reduction in their Ca and PTH-rP levels, and the six of ten EORTC QLQ-C30 subscales (emotional functioning, cognitive functioning, fatigue, dyspnoea, nausea/vomiting and appetite loss) were also improved after the anti-hypercalcemic therapy.
Gene_expression (levels) of PTH-rP associated with appetite loss, cognitive disorder, malignant neoplastic disease, vomiting, fatigue and dyspnea
10) Confidence 0.31 Published 2003 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 12729778 Disease Relevance 1.99 Pain Relevance 0.06
There is convincing evidence that RCC tumor cells elaborate proteins that serve as mediators of endocrine (eg, ectopic production of parathyroid hormone-related protein or erythropoietin) as well as nonendocrine paraneoplastic syndromes.
Gene_expression (production) of parathyroid hormone-related protein in parathyroid associated with cancer, renal cancer and paraneoplastic syndromes
11) Confidence 0.23 Published 1996 Journal Semin. Urol. Oncol. Section Abstract Doc Link 8946620 Disease Relevance 1.23 Pain Relevance 0
[A case of bladder tumor producing granulocyte-colony stimulation factor and parathyroid hormone-related protein].
Gene_expression (producing) of parathyroid hormone-related protein in parathyroid associated with bladder cancer
12) Confidence 0.16 Published 2001 Journal Hinyokika Kiyo Section Title Doc Link 11828777 Disease Relevance 0.62 Pain Relevance 0.15
The neuronal changes in SA animals were correlated with elevated adrenocorticotrophic hormone (ACTH) (64% and 104%) and glucocorticoid production (198% and 79%) compared with YH and YS groups, respectively.
Gene_expression (production) of adrenocorticotrophic hormone in neuronal
13) Confidence 0.05 Published 2009 Journal Brain Behav. Immun. Section Abstract Doc Link 19467321 Disease Relevance 0.15 Pain Relevance 0.31
Bone-derived TGFbeta plays an integral role in promoting the development and progression of osteolytic bone metastases by inducing tumor production of parathyroid hormone-related protein (PTHrP), a known stimulator of osteoclastic bone resorption.
Gene_expression (production) of hormone-related protein in parathyroid associated with cancer, hypercalcemia, osteoporosis and metastasis
14) Confidence 0.02 Published 2000 Journal Crit. Rev. Eukaryot. Gene Expr. Section Abstract Doc Link 11186331 Disease Relevance 1.97 Pain Relevance 0.05
Prolactin is a protein hormone synthesized and secreted by the anterior pituitary gland.
Gene_expression (synthesized) of protein hormone in gland
15) Confidence 0.01 Published 1981 Journal Am J Psychiatry Section Abstract Doc Link 7023253 Disease Relevance 0.29 Pain Relevance 0.24

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