INT46533

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.18
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ces1c) endoplasmic reticulum (Ces1c)
Anatomy Link Frequency
spermatozoa 3
heads 2
plasma 1
cranial nerve X 1
cauda epididymis 1
Ces1c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 1 95.80 Very High Very High Very High
Enkephalin 6 93.24 High High
medulla 1 85.88 High High
headache 1 17.04 Low Low
addiction 14 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sperm Disorder 24 74.48 Quite High
Targeted Disruption 48 54.80 Quite High
Death 12 40.24 Quite Low
Congenital Anomalies 19 38.80 Quite Low
Headache 2 17.04 Low Low
Alopecia 1 16.24 Low Low
Nasopharyngitis 1 15.44 Low Low
Arthralgia 1 11.68 Low Low
Diarrhoea 1 10.40 Low Low
Male Infertility 12 7.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At week 36 (12 weeks after completion of active treatment), plasma E1, E2, and E1S concentrations had returned to near baseline for the three active-treatment groups and were again similar to those observed in the placebo group.


E1 Binding (returned) of in plasma
1) Confidence 0.12 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206728 Disease Relevance 0 Pain Relevance 0
Indirect immunofluorescence assay further validated that the HongrES1 protein is secreted into the lumen of the cauda epididymis and is bound to sperm (Figure 1I).
HongrES1 Binding (bound) of in cauda epididymis
2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
As expected, the number of spermatozoa bound with HongrES1 protein in the RNAi-treated rats decreased down to about 60% of the scrambled control as shown in Figures 4C and 4D.
HongrES1 Binding (bound) of in spermatozoa
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.13 Pain Relevance 0
Our results suggest a clear role for HongrES1 protein, spermatozoa would bind HongrES1 on their heads and this protein would act by timing capacitation to take place in the right time and place.
HongrES1 Binding (bind) of in heads
4) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
When cauda epididymal spermatozoa that are bound by HongrES1 were incubated in capacitation medium, the binding immunofluorescence signal attenuated gradually and disappeared (Figure 3D, 3E and 3F).
HongrES1 Binding (bound) of in spermatozoa
5) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
Our results suggest a clear role for HongrES1 protein, spermatozoa would bind HongrES1 on their heads and this protein would act by timing capacitation to take place in the right time and place.
HongrES1 Binding (bind) of in heads
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0 Pain Relevance 0
This strongly suggests that changes in HongrES1 protein binding are involved in sperm capacitation and/or the acrosome reaction in vitro.
HongrES1 Binding (binding) of in sperm
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2606034 Disease Relevance 0.05 Pain Relevance 0
Immunoreactive cell bodies were found in the telencephalon, diencephalon, and mesencephalon in areas as yet uncharacterized as discrete nuclei in birds (E-1, E-2, E-3, E-4, E-5); further cells were located in the diencephalic nucleus spiriformis lateralis, the midbrain medial intercollicular nucleus (E-6), the nucleus mesencephalicus lateralis, pars dorsalis, the Edinger-Westphal nucleus and dorsal occulomotor nucleus; and in the nucleus of cranial nerve X and an uncharacterized area in the dorsolateral medulla (E-7).
E-1 Binding (birds) of in cranial nerve X associated with medulla and midbrain
8) Confidence 0.03 Published 1981 Journal J. Comp. Neurol. Section Abstract Doc Link 7024329 Disease Relevance 0 Pain Relevance 0.34
Among other possibilities, several carboxylates help to coordinate transported Na and K ions in the binding pockets and thus may be expected to change their accessibility between E1 and E2 major conformations.
E1 Binding (accessibility) of
9) Confidence 0.03 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2894553 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox