INT4656

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Context Info
Confidence 0.77
First Reported 1976
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 49
Total Number 58
Disease Relevance 5.28
Pain Relevance 46.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
liver 3
plasma 2
urine 2
blood 1
platelet 1
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 622 100.00 Very High Very High Very High
5HT 1 100.00 Very High Very High Very High
addiction 5 99.32 Very High Very High Very High
Bile 31 98.94 Very High Very High Very High
Inflammation 1 83.08 Quite High
Analgesic 1 81.64 Quite High
anesthesia 1 76.40 Quite High
agonist 1 65.44 Quite High
aspirin 3 29.68 Quite Low
Pain 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 32 98.28 Very High Very High Very High
Necrosis 7 98.24 Very High Very High Very High
Methemoglobinemia 1 98.12 Very High Very High Very High
Weight Loss 10 98.00 Very High Very High Very High
Targeted Disruption 3 96.60 Very High Very High Very High
Nephrotoxicity 18 94.92 High High
Stress 11 93.48 High High
Breast Cancer 2 90.60 High High
INFLAMMATION 1 83.08 Quite High
Toxicity 5 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A two factor, three level (3(2)) full factorial study design was used to optimize the ratios of AMCE and EC, and the release of APAP from the wax matrix was evaluated using a stationary disk in accordance with the paddle method.
Localization (release) of APAP associated with paracetamol
1) Confidence 0.77 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.58
Therefore, the present study demonstrated that the incorporation of AMCE and EC into a wax matrix system enabled the appropriate release of APAP as a means of taste masking.
Localization (release) of APAP associated with paracetamol
2) Confidence 0.77 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.71
Tablet erosion studies indicated that the amount of APAP released was linearly related to the percentage of tablet weight loss.
Localization (released) of APAP associated with paracetamol and weight loss
3) Confidence 0.77 Published 1997 Journal Pharm Dev Technol Section Abstract Doc Link 9552442 Disease Relevance 0.19 Pain Relevance 0.96
For the combined excretion of APAP-cysteine and APAP-mercapturate, the k(m) was 0.303 mmol/L (0.131-0.475) and the V(max) was 0.004 mmol/h per kg (0.002-0.005). 4.
Localization (excretion) of APAP associated with paracetamol
4) Confidence 0.68 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18759860 Disease Relevance 0 Pain Relevance 0.76
For the combined excretion of APAP-cysteine and APAP-mercapturate, the k(m) was 0.303 mmol/L (0.131-0.475) and the V(max) was 0.004 mmol/h per kg (0.002-0.005). 4.
Localization (excretion) of APAP associated with paracetamol
5) Confidence 0.68 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18759860 Disease Relevance 0 Pain Relevance 0.75
Urinary excretion of unchanged APAP, APAP-sulfate, and APAP-glucuronide was complete within 30 hr at all ages.
Localization (excretion) of APAP associated with paracetamol
6) Confidence 0.68 Published 1976 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 1261167 Disease Relevance 0 Pain Relevance 0.79
As expected, the percent release of APAP from coated core tablets was highly pH dependent.
Localization (release) of APAP associated with paracetamol
7) Confidence 0.68 Published 2002 Journal AAPS PharmSciTech Section Abstract Doc Link 12916927 Disease Relevance 0 Pain Relevance 0.28
Urinary excretion of unchanged APAP, APAP-sulfate, and APAP-glucuronide was complete within 30 hr at all ages.
Localization (excretion) of APAP associated with paracetamol
8) Confidence 0.68 Published 1976 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 1261167 Disease Relevance 0 Pain Relevance 0.79
Overall, the results of this study indicated that PE, as a co-active in the formulation, modified the matrix, and hence retarded APAP release.
Localization (release) of APAP associated with paracetamol
9) Confidence 0.68 Published 1997 Journal Pharm Dev Technol Section Abstract Doc Link 9552442 Disease Relevance 0.18 Pain Relevance 0.67
Furthermore, using multiple regression analysis, the optimum ratio of APAP:AMCE:EC:GM was found to be 30:7:10:53, and the release pattern of APAP from the optimum wax formulation nearly complied with the desired criteria.
Localization (release) of APAP associated with paracetamol
10) Confidence 0.67 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.92
In multiple regression analysis, the release of APAP at pH 4.0 was found to increase markedly as the concentration of AMCE increased, whereas the release of APAP at pH 6.5 decreased as the EC concentration increased, even when a high level of AMCE was incorporated.
Localization (release) of APAP associated with paracetamol
11) Confidence 0.67 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.93
Using principle component analysis, it was found that the viscosity of the matrix affects the pH-dependent release of APAP at pH 4.0 and pH 6.5.
Localization (release) of APAP associated with paracetamol
12) Confidence 0.67 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.93
In multiple regression analysis, the release of APAP at pH 4.0 was found to increase markedly as the concentration of AMCE increased, whereas the release of APAP at pH 6.5 decreased as the EC concentration increased, even when a high level of AMCE was incorporated.
Localization (release) of APAP associated with paracetamol
13) Confidence 0.67 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.87
In contrast, the excretion of APAP-NAC did not exhibit dependence on APAP-GSH concentration.
Localization (excretion) of APAP-NAC associated with addiction
14) Confidence 0.64 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2871175 Disease Relevance 0 Pain Relevance 0.19
APAP-NAC was excreted by a probenecid sensitive transport mechanism whereas APAP-CYS excretion appeared to be related only to glomerular filtration.
Localization (excretion) of APAP-CYS
15) Confidence 0.64 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2871175 Disease Relevance 0 Pain Relevance 0.18
However, as the concentration of APAP-GSH was increased so did the excretion of APAP-CYS.
Localization (excretion) of APAP-CYS
16) Confidence 0.64 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2871175 Disease Relevance 0 Pain Relevance 0.19
CFB pretreatment did not affect bile flow rate, nor did it affect the cumulative biliary excretion of APAP and its conjugated metabolites. 4.
Localization (excretion) of APAP in bile associated with paracetamol and bile
17) Confidence 0.61 Published 2000 Journal Xenobiotica Section Abstract Doc Link 11197064 Disease Relevance 0 Pain Relevance 1.01
APAP-NAC was excreted by a probenecid sensitive transport mechanism whereas APAP-CYS excretion appeared to be related only to glomerular filtration.
Localization (excreted) of APAP-NAC
18) Confidence 0.60 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2871175 Disease Relevance 0 Pain Relevance 0.18
At pH 1.16, a decline in the percentage of APAP released occurred after 18 hours.
Localization (released) of APAP associated with paracetamol
19) Confidence 0.59 Published 1997 Journal Pharm Dev Technol Section Abstract Doc Link 9552442 Disease Relevance 0.13 Pain Relevance 0.98
Urinary excretion of unchanged APAP, APAP-sulfate, and APAP-glucuronide was complete within 30 hr at all ages.
Localization (excretion) of APAP associated with paracetamol
20) Confidence 0.59 Published 1976 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 1261167 Disease Relevance 0 Pain Relevance 0.80

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