INT4658

Context Info Confidence 0.48 First Reported 1976 Last Reported 2010 Negated 2 Speculated 16 Reported most in Abstract Documents 188 Total Number 203 Disease Relevance 25.96 Pain Relevance 136.24

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1) signal transducer activity (OPRM1)

Anatomy Link Frequency brain 7 plasma 5 tail 3 immune cells 3 SH-SY5Y 2 OPRM1 (Homo sapiens) OPRM1 - A118G (2) OPRM1 - S268P (1)

Pain Link Frequency Relevance Heat opioid receptor 2713 100.00 narcan 1519 100.00 mu opioid receptor 1334 100.00 Opioid 1289 100.00 Morphine 1120 100.00 antagonist 591 100.00 Pain 562 100.00 agonist 374 100.00 opiate 238 100.00 substance P 91 100.00

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 12 100.00 Nociception 140 99.84 Suicidal Behaviour 7 99.84 Syndrome 41 99.82 Pain 599 99.76 Nicotine Addiction 384 99.76 Opiate Addiction 32 99.76 Immunodeficiency 7 99.64 Epilepsy 2 99.60 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 218 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mu opioid receptor (MOR) is the main site of interaction for major clinical analgesics, particularly morphine.

MOR Binding (interaction) of associated with analgesic, mu opioid receptor and morphine

1) Confidence 0.48 Published 2010 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19438807 Disease Relevance 0 Pain Relevance 0.50

Mu opioid receptor (MOR) is the main site of interaction for major clinical analgesics, particularly morphine.

Mu opioid receptor Binding (interaction) of associated with analgesic, mu opioid receptor and morphine

2) Confidence 0.48 Published 2010 Journal J. Cell. Mol. Med. Section Abstract Doc Link 19438807 Disease Relevance 0 Pain Relevance 0.50

These data suggest that MOR ligands, such as naloxone, can cross the plasma membrane and MOR1K is a functional intracellular receptor that binds MOR ligands.

MOR1K Binding (binds) of in plasma associated with narcan and opioid receptor

3) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.06 Pain Relevance 0.67

As intracellular localization of several receptor systems does not prevent receptor-mediated signalling [34,35], we examined whether the intracellulary localized MOR1K binds MOR ligands using flow cytometry [36] to measure binding of fluorescently labeled naloxone (Fig.1D-E).

MOR1K Spec (whether) Binding (binds) of associated with narcan and opioid receptor

4) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.19 Pain Relevance 0.37

OBJECTIVE: 11C-carfentanil is a radiopharmaceutical that selectively binds the mu-opiate receptor of the central nervous system.

mu-opiate receptor Binding (binds) of in central nervous system associated with central nervous system and opiate

5) Confidence 0.48 Published 2009 Journal Nucl Med Commun Section Abstract Doc Link 19242386 Disease Relevance 0 Pain Relevance 0.23

We found, however, that opiate receptor binding is high in the fetal and infant inferior olive, in comparison to low binding reported in this site in adult humans, primates, and rodents.

opiate receptor Binding (binding) of in inferior olive associated with opiate

6) Confidence 0.48 Published 1990 Journal J. Comp. Neurol. Section Abstract Doc Link 2153713 Disease Relevance 0.09 Pain Relevance 1.25

Sufentanil is the most potent of the opioids currently available for use in man, it has a very high binding affinity for the mu-opioid receptor.

mu-opioid receptor Binding (affinity) of associated with opioid receptor and opioid

7) Confidence 0.48 Published 1991 Journal Agressologie Section Abstract Doc Link 1688220 Disease Relevance 0 Pain Relevance 0.64

The relative potency of the analgesic effect is related to the characteristics of the opiate receptor interaction (KD, Ki).

opiate receptor Binding (interaction) of associated with analgesic, opiate and potency

8) Confidence 0.48 Published 1991 Journal Agressologie Section Abstract Doc Link 1688220 Disease Relevance 0 Pain Relevance 0.67

The failure of naloxone to inhibit morphine-induced histamine release suggests that histamine release by morphine is not dependent on opiate receptor binding or activation.

opiate receptor Binding (binding) of associated with narcan, opiate and morphine

9) Confidence 0.48 Published 1985 Journal Anesthesiology Section Abstract Doc Link 2578752 Disease Relevance 0 Pain Relevance 1.14

To better understand structural requirements for a mu ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with the mu opioid receptor, we have described in the previous article (Le Bourdonnec, B. et al.

mu opioid receptor Binding (interact) of associated with mu opioid receptor

10) Confidence 0.48 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 17149859 Disease Relevance 0 Pain Relevance 0.35

In this study the authors examined age- and gender-associated variations in mu-opioid receptor binding with positron emission tomography (PET).

mu-opioid receptor Spec (examined) Binding (binding) of associated with positron emission tomography and opioid receptor

11) Confidence 0.48 Published 1999 Journal Am J Psychiatry Section Abstract Doc Link 10360121 Disease Relevance 0 Pain Relevance 0.28

Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving.

mu opioid receptor Binding (binding) of associated with mu opioid receptor and cocaine

12) Confidence 0.47 Published 1996 Journal Nat. Med. Section Title Doc Link 8898749 Disease Relevance 0 Pain Relevance 0.88

In this study we examined mu opioid receptor binding in ten cocaine-dependent men and seven nonaddicted controls using positron emission tomography and [11C] carfentanil.

mu opioid receptor Spec (examined) Binding (binding) of associated with positron emission tomography, mu opioid receptor and cocaine

13) Confidence 0.47 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8898749 Disease Relevance 0 Pain Relevance 0.83

The upregulation of mu opioid receptor binding persisted after 4 weeks of monitored cocaine abstinence.

mu opioid receptor Binding (binding) of associated with mu opioid receptor and cocaine

14) Confidence 0.47 Published 1996 Journal Nat. Med. Section Abstract Doc Link 8898749 Disease Relevance 0 Pain Relevance 0.92

We found that a clinically used TP extract bound to the mu-opiate receptor with a high affinity (K(i)=9.7+/-1.6microg/ml).

mu-opiate receptor Binding (bound) of associated with opiate

15) Confidence 0.47 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17350196 Disease Relevance 0.09 Pain Relevance 0.52

Peptoid trimer CHIR 2279 binds to the alpha 1-adrenergic receptor with a Ki of 5 nM, and trimer CHIR 4531 binds to the mu-opiate receptor with a Ki of 6 nM.

mu-opiate receptor Binding (binds) of associated with opiate

16) Confidence 0.47 Published 1994 Journal J. Med. Chem. Section Abstract Doc Link 8064796 Disease Relevance 0 Pain Relevance 0.10

Naloxonazine binds irreversibly to the mu 1-opioid receptor subtype and reversibly to the mu 2-opioid receptor subtype.

mu 1-opioid Binding (binds) of associated with opioid receptor

17) Confidence 0.47 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7805771 Disease Relevance 0.10 Pain Relevance 0.49

Interaction of the mu-opioid receptor (MOP) with selected ligands was investigated in live cells using advanced imaging by confocal laser scanning microscopy integrated with fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

mu-opioid receptor Binding (Interaction) of associated with opioid receptor and imagery

18) Confidence 0.47 Published 2008 Journal FASEB J. Section Abstract Doc Link 18587007 Disease Relevance 0 Pain Relevance 0.32

Interaction of the mu-opioid receptor (MOP) with selected ligands was investigated in live cells using advanced imaging by confocal laser scanning microscopy integrated with fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy.

MOP Binding (Interaction) of associated with opioid receptor and imagery

19) Confidence 0.47 Published 2008 Journal FASEB J. Section Abstract Doc Link 18587007 Disease Relevance 0 Pain Relevance 0.32

In the nervous system, the interaction of opioids like heroin and morphine with the G protein-coupled Mu-opioid receptor (MOR) provokes the development of tolerance to these opioids, as well as physical dependence.

MOR Binding (interaction) of in nervous system associated with physical dependence, tolerance, opioid receptor, opioid and morphine

20) Confidence 0.47 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630721 Disease Relevance 0.17 Pain Relevance 1.04

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