INT46582

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Context Info
Confidence 0.48
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 1.49
Pain Relevance 13.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
ventral 4
spinal 2
spinal cord 2
neurons 2
terminal portion 1
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 58 100.00 Very High Very High Very High
Morphine 53 100.00 Very High Very High Very High
Ventral tegmentum 42 100.00 Very High Very High Very High
Opioid 41 100.00 Very High Very High Very High
Spinal cord 14 100.00 Very High Very High Very High
Analgesic 5 100.00 Very High Very High Very High
opioid receptor 16 99.96 Very High Very High Very High
Central nervous system 2 99.60 Very High Very High Very High
Endogenous opioid 9 98.56 Very High Very High Very High
Antinociceptive 2 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 10 98.24 Very High Very High Very High
Stress 8 91.24 High High
Hyperphagia 1 90.32 High High
INFLAMMATION 2 75.76 Quite High
Pain 4 75.60 Quite High
Hyperalgesia 1 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NPFF-like material in superfusates recognized spinal NPFF receptors, suggesting that NPFF release in the spinal cord has a physiological role.
NPFF Binding (recognized) of in spinal associated with spinal cord
1) Confidence 0.48 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7891084 Disease Relevance 0.06 Pain Relevance 0.55
It was found that dansyl-PQRFamide and dansyl-RFamide also bound to NPFF receptors with Ki values of 6.1 and 73 nM, respectively.
NPFF Binding (bound) of
2) Confidence 0.48 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229791 Disease Relevance 0 Pain Relevance 0.45
It was proved to bind to its own receptors, namely NPFF(1) and NPFF(2) receptors, but did not bind to opioid receptors.
NPFF Binding (bind) of associated with opioid receptor
3) Confidence 0.48 Published 2010 Journal Peptides Section Abstract Doc Link 20381562 Disease Relevance 0 Pain Relevance 0.68
Recent studies have described the occurrence of another octapeptide, neuropeptide SF (NPSF) in the spinal cord and the cerebrospinal fluid and demonstrated its affinity for the NPFF receptors.
NPFF Binding (affinity) of in spinal cord associated with neuropeptide and spinal cord
4) Confidence 0.47 Published 2006 Journal Peptides Section Abstract Doc Link 16515821 Disease Relevance 0.34 Pain Relevance 0.83
Although both peptidomimetics were far more potent than FMRFa itself, they bound with lower affinity than FMRFa to rat spinal cord receptors for the mammalian FMRFa-like peptide, NPFF.
NPFF Binding (bound) of in spinal cord associated with spinal cord
5) Confidence 0.47 Published 1993 Journal Peptides Section Abstract Doc Link 8382812 Disease Relevance 0 Pain Relevance 0.28
Acid sensing ion channels were found to respond to RF-NH2 peptides including NPFF, raising the possibility that interaction of NPFF and acid sensing ion channels can modulate nociceptive activity.
NPFF Binding (interaction) of associated with nociception
6) Confidence 0.42 Published 2006 Journal Peptides Section Abstract Doc Link 16443306 Disease Relevance 0.54 Pain Relevance 0.61
It was proved to bind to its own receptors, namely NPFF(1) and NPFF(2) receptors, but did not bind to opioid receptors.
NPFF Binding (bind) of associated with opioid receptor
7) Confidence 0.42 Published 2010 Journal Peptides Section Abstract Doc Link 20381562 Disease Relevance 0 Pain Relevance 0.67
Among these antiopioids, neuropeptide FF (NPFF) is particularly interesting since both NPFF immunoreactive-like terminals and NPFF binding sites are located in the vicinity of the dopaminergic cell bodies within the ventral tegmental area (VTA) suggesting an interaction at this level.
NPFF Binding (interaction) of in ventral associated with ventral tegmentum and neuropeptide
8) Confidence 0.37 Published 2002 Journal Neuroscience Section Abstract Doc Link 11958872 Disease Relevance 0.09 Pain Relevance 1.10
The radioligand binding and G-protein coupling of NPFF receptors were not altered by chronic morphine treatment.
NPFF Binding (binding) of associated with morphine
9) Confidence 0.37 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229791 Disease Relevance 0 Pain Relevance 0.31
Among these antiopioids, neuropeptide FF (NPFF) is particularly interesting since both NPFF immunoreactive-like terminals and NPFF binding sites are located in the vicinity of the dopaminergic cell bodies within the ventral tegmental area (VTA) suggesting an interaction at this level.
NPFF Binding (interesting) of in ventral associated with ventral tegmentum and neuropeptide
10) Confidence 0.33 Published 2002 Journal Neuroscience Section Abstract Doc Link 11958872 Disease Relevance 0.09 Pain Relevance 0.90
Among these antiopioids, neuropeptide FF (NPFF) is particularly interesting since both NPFF immunoreactive-like terminals and NPFF binding sites are located in the vicinity of the dopaminergic cell bodies within the ventral tegmental area (VTA) suggesting an interaction at this level.
neuropeptide FF Binding (interesting) of in ventral associated with ventral tegmentum and neuropeptide
11) Confidence 0.33 Published 2002 Journal Neuroscience Section Abstract Doc Link 11958872 Disease Relevance 0.09 Pain Relevance 0.90
Many of the behavioral effects of NPFF have also been observed with the invertebrate neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide), which binds to NPFF receptors because of its low homology to the C-terminal portion of NPFF.
NPFF Binding (binds) of in terminal portion associated with neuropeptide
12) Confidence 0.32 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229791 Disease Relevance 0 Pain Relevance 0.56
Interaction between neuropeptide FF and opioids in the ventral tegmental area in the behavioral response to novelty.
neuropeptide FF Binding (Interaction) of in ventral associated with ventral tegmentum, neuropeptide and opioid
13) Confidence 0.31 Published 2002 Journal Neuroscience Section Title Doc Link 11958872 Disease Relevance 0.09 Pain Relevance 0.95
It was found that FMRFamide (Ki = 1.8 nM) bound with lower affinity than NPFF (0.26 nM) but it was about 7-fold more potent than PQRFamide (12 nM).
NPFF Binding (bound) of
14) Confidence 0.31 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8229791 Disease Relevance 0 Pain Relevance 0.53
In addition, they suggest that reciprocal excitatory interactions between opioids and opioid-modulatory factors (such as NPFF) participate in the physiological control of nociception.
NPFF Binding (interactions) of associated with nociception and opioid
15) Confidence 0.31 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471085 Disease Relevance 0.10 Pain Relevance 0.98
In the present study, we have used the hippocampal response to opioids to examine the potential interactions between morphine and NPFF in vitro.
NPFF Binding (interactions) of associated with opioid and morphine
16) Confidence 0.31 Published 1997 Journal Brain Res. Section Abstract Doc Link 9098532 Disease Relevance 0 Pain Relevance 0.99
Several high-affinity analogs of neuropeptide FF (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2, NPFF) exhibiting both supraspinal anti-opioid and spinal analgesic activities were studied for their abilities to interact with specific mu, delta, and kappa opioid binding in the rat spinal cord.
NPFF Binding (interact) of in spinal associated with analgesic, neuropeptide, opioid and spinal cord
17) Confidence 0.31 Published 1998 Journal Peptides Section Abstract Doc Link 9622028 Disease Relevance 0 Pain Relevance 0.73
These results suggest that NPFF-induced satiety has a relationship with mu and kappa but not delta subtypes of opioid receptors, and since NPFF does not bind opioid receptors itself NPFF-associated satiety is likely mediated by effects on opioid receptor ligands such as NPY and beta-endorphin.
NPFF Neg (not) Binding (bind) of associated with opioid receptor
18) Confidence 0.23 Published 2008 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 18823989 Disease Relevance 0.09 Pain Relevance 0.67
By promoting NPFF-MOP receptor heteromerization, 1DMe could disrupt the domain organization of MOP receptors in the membrane, resulting in a reduction of opioid response.
NPFF Binding (heteromerization) of associated with opioid
19) Confidence 0.16 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17224450 Disease Relevance 0 Pain Relevance 0.93
It is suggested that neurons in the rat central nervous system have receptors for FMRFamide that normally bind endogenous material with FMRFamide immunoreactivity.
FMRFamide Binding (bind) of in neurons associated with central nervous system
20) Confidence 0.09 Published 1981 Journal Peptides Section Abstract Doc Link 7045830 Disease Relevance 0 Pain Relevance 0.19

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