INT46605

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Context Info
Confidence 0.49
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.33
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
muscle 2
extracellular matrix 2
heart 2
myocardium 1
sinoatrial node 1
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 16 100.00 Very High Very High Very High
Pain 10 99.64 Very High Very High Very High
depression 28 98.44 Very High Very High Very High
Pain threshold 6 96.64 Very High Very High Very High
Action potential 319 96.04 Very High Very High Very High
Peripheral nervous system 3 89.52 High High
Central nervous system 3 56.00 Quite High
analgesia 4 48.32 Quite Low
metalloproteinase 44 13.96 Low Low
fibrosis 22 9.72 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 60 100.00 Very High Very High Very High
Anxiety Disorder 31 100.00 Very High Very High Very High
Stress 30 100.00 Very High Very High Very High
Hypertrophy 66 99.56 Very High Very High Very High
Heart Rate Under Development 99 99.16 Very High Very High Very High
Depression 30 98.44 Very High Very High Very High
Pain 14 96.68 Very High Very High Very High
Targeted Disruption 11 96.20 Very High Very High Very High
Mitochondrial Disorders 39 95.84 Very High Very High Very High
Muscular Atrophy 6 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of stimulation of acupuncture loci Nei-Kuan (EH-6), Tsu-San-Li (St-36), San-Yin-Chiao (Sp-6) and Chu-Chih (LI-11) on cutaneous circulation and/or pain threshold were assessed in eight normal adults.
Positive_regulation (stimulation) of San associated with pain threshold and acupuncture
1) Confidence 0.49 Published 1981 Journal Am. J. Chin. Med. Section Abstract Doc Link 7053029 Disease Relevance 0.31 Pain Relevance 0.30
Effects of needle stimulation of acupuncture loci Nei-Kuan (EH-6), Tsu-San-Li (St-36), San-Yin-Chiao (Sp-6) and Chu-Chih (LI-11) on cutaneous temperature and pain threshold in normal adults.
Positive_regulation (stimulation) of San associated with pain, pain threshold and acupuncture
2) Confidence 0.49 Published 1981 Journal Am. J. Chin. Med. Section Title Doc Link 7053029 Disease Relevance 0.46 Pain Relevance 0.51
Interestingly, in the guinea pig, the increase of the SAN is greater than can be explained by any increase in heart size [27].
Positive_regulation (increase) of SAN in heart
3) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.09 Pain Relevance 0.12
What are the functional correlates of the increase in the SAN?
Positive_regulation (increase) of SAN
4) Confidence 0.19 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.10 Pain Relevance 0.08
In old animals, cell diameter was significantly increased by 38% and 23% in the SAN and atrial muscle, respectively (Fig. 6C).
Positive_regulation (increased) of SAN in muscle
5) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.13 Pain Relevance 0.06
Calculation shows that the increase in SAN cell diameter of 38% is expected to increase the volume of the SAN by 90% and this is similar to that observed experimentally (97%).


Positive_regulation (increase) of SAN
6) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.15 Pain Relevance 0
It is concluded that the age-dependent decline in SAN function is associated with a structural remodelling of the SAN: an increase in SAN tissue, a hypertrophy of the SAN cells and a remodelling of the extracellular matrix.
Positive_regulation (increase) of SAN in extracellular matrix associated with hypertrophy
7) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.27 Pain Relevance 0
It is concluded that the age-dependent decline in SAN function is associated with a structural remodelling of the SAN: an increase in SAN tissue, a hypertrophy of the SAN cells and a remodelling of the extracellular matrix.
Positive_regulation (increase) of SAN in extracellular matrix associated with hypertrophy
8) Confidence 0.14 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.27 Pain Relevance 0
However, the increase in SAN tissue lacking expression of Nav1.5 cannot explain the age-dependent decrease in the intrinsic heart rate, because blockade of Nav1.5 by 2 ?
Positive_regulation (increase) of SAN in heart
9) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.34 Pain Relevance 0.04
Calculation shows that the increase in SAN cell diameter of 38% is expected to increase the volume of the SAN by 90% and this is similar to that observed experimentally (97%).


Positive_regulation (increase) of SAN
10) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.14 Pain Relevance 0.03
The increase in SAN tissue lacking expression of Nav1.5 possibly could help explain the increase in the SAN conduction time observed in the elderly and SAN exit block in sick sinus syndrome [30] if the SAN action potential has to propagate a greater distance from the leading pacemaker site in the SAN through tissue lacking Nav1.5 to reach the surrounding atrial muscle [2].
Positive_regulation (increase) of SAN in muscle associated with action potential and heart rate under development
11) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.31 Pain Relevance 0.05
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Positive_regulation (increase) of SAN in myocardium
12) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.07 Pain Relevance 0.16
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age – there is a decrease in the intrinsic heart rate (heart rate in absence of autonomic tone) and an increase in the SAN conduction time [2].
Positive_regulation (increase) of SAN in sinoatrial node
13) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.53 Pain Relevance 0.03
A preliminary examination of pedigree data showed that all affected dogs could be traced back to a female on the maternal side that lived in the 1970s, suggesting that SAN could be caused by a mutation in the mitochondrial genome (mtDNA).
Positive_regulation (caused) of SAN associated with neuropathic pain
14) Confidence 0.06 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2683749 Disease Relevance 1.02 Pain Relevance 0.15
We here show that SAN in golden retrievers is caused by a mutation in the mitochondrial tRNATyr gene.
Positive_regulation (caused) of SAN associated with neuropathic pain
15) Confidence 0.06 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2683749 Disease Relevance 0.46 Pain Relevance 0
In this study, we report the identification and characterization of the mutation causing SAN, a single base pair deletion in the mitochondrial tRNATyr gene.
Positive_regulation (causing) of SAN associated with neuropathic pain
16) Confidence 0.05 Published 2009 Journal PLoS Genetics Section Abstract Doc Link PMC2683749 Disease Relevance 0.99 Pain Relevance 0.10
Twenty-one of 33 randomized and nonrandomized trials reported that 1 hour to 1 year of regular Tai Chi significantly increased psychological well-being including reduction of stress (effect size [ES], 0.66; 95% confidence interval [CI], 0.23 to 1.09), anxiety (ES, 0.66; 95% CI, 0.29 to 1.03), and depression (ES, 0.56; 95% CI, 0.31 to 0.80), and enhanced mood (ES, 0.45; 95% CI, 0.20 to 0.69) in community-dwelling healthy participants and in patients with chronic conditions.
Positive_regulation (increased) of anxiety associated with stress, depression and anxiety disorder
17) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Abstract Doc Link PMC2893078 Disease Relevance 0.69 Pain Relevance 0.11

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