INT46615

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Context Info
Confidence 0.57
First Reported 1982
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.10
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
Anatomy Link Frequency
Lips 4
parathyroid 4
crest 2
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 93.60 High High
palliative 1 81.16 Quite High
Pain 10 67.36 Quite High
headache 10 62.76 Quite High
withdrawal 2 50.84 Quite High
fibrosis 110 20.56 Low Low
backache 11 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High
Disease 11 99.76 Very High Very High Very High
Parathyroid Cancer 6 96.12 Very High Very High Very High
Bone Cancer 37 93.28 High High
Hypercalcemia 99 90.64 High High
Recurrence 2 89.68 High High
Osteoporosis 190 88.40 High High
Malignant Neoplastic Disease 2 88.40 High High
Hypophosphatemia 2 84.20 Quite High
Apoptosis 5 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patho-physiologic observations suggested that the tumor secreted some humoral substances inhibiting 25-hydroxyvitamin D-1 alpha-hydroxylase activity, renal phosphate resorption, and parathyroid hormone production.
Negative_regulation (inhibiting) of Gene_expression (production) of parathyroid hormone in parathyroid associated with cancer
1) Confidence 0.57 Published 1996 Journal Pathol. Int. Section Abstract Doc Link 10846577 Disease Relevance 0.91 Pain Relevance 0.07
Furthermore, no abnormal histopathologic findings were reported in iliac crest biopsies after 12 and 18 months of PTH therapy in a subset of 40 women in the TOP trial18 and after 36 months in 14 patients in the TRES study.41
Negative_regulation (reported) of Gene_expression (therapy) of PTH in crest
2) Confidence 0.42 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971708 Disease Relevance 0.90 Pain Relevance 0.06
The failure of this tumor to produce parathyroid hormone may allow it to escape clinical attention until it has achieved an advanced state.
Negative_regulation (failure) of Gene_expression (produce) of parathyroid hormone in parathyroid associated with cancer
3) Confidence 0.42 Published 1982 Journal Cancer Section Abstract Doc Link 7053835 Disease Relevance 1.22 Pain Relevance 0.08
The present data confirm that both doses produced a significant suppression of PTH.
Negative_regulation (suppression) of Gene_expression (produced) of PTH
4) Confidence 0.40 Published 2004 Journal Nutr J Section Body Doc Link PMC506781 Disease Relevance 0 Pain Relevance 0
The decrease in intestinal calcium absorption and high prevalence of vitamin D insufficiency and deficiency seen in elderly men both contribute to elevated serum parathyroid hormone (PTH) levels and bone loss (Lips 2001).
Negative_regulation (loss) of Gene_expression (levels) of PTH in Lips
5) Confidence 0.39 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.75 Pain Relevance 0
At the time of discontinuation the rate of patients treated with refracted dose regimens, adopted after adverse events, was higher in PTH groups ?
Negative_regulation (higher) of Gene_expression (groups) of PTH
6) Confidence 0.37 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971708 Disease Relevance 0.29 Pain Relevance 0.12
The decrease in intestinal calcium absorption and high prevalence of vitamin D insufficiency and deficiency seen in elderly men both contribute to elevated serum parathyroid hormone (PTH) levels and bone loss (Lips 2001).
Negative_regulation (loss) of Gene_expression (levels) of serum parathyroid hormone in Lips
7) Confidence 0.34 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682396 Disease Relevance 0.76 Pain Relevance 0.03
Positive allosteric modulators decrease PTH production, while negative modulators increase it.
Negative_regulation (decrease) of Gene_expression (production) of PTH
8) Confidence 0.23 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.26 Pain Relevance 0.05

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