INT46619

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Context Info
Confidence 0.73
First Reported 1982
Last Reported 2011
Negated 4
Speculated 7
Reported most in Body
Documents 80
Total Number 86
Disease Relevance 36.63
Pain Relevance 12.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
chondrocytes 15
macrophage 12
monocyte 7
osteoblasts 6
plasma 2
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 449 100.00 Very High Very High Very High
metalloproteinase 95 100.00 Very High Very High Very High
endometriosis 504 99.78 Very High Very High Very High
Migraine 6 99.68 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 44 99.64 Very High Very High Very High
Cluster headache 4 99.16 Very High Very High Very High
Angina 10 99.02 Very High Very High Very High
rheumatoid arthritis 38 98.60 Very High Very High Very High
spinal inflammation 4 98.48 Very High Very High Very High
Inflammation 501 96.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Leukemia 1 100.00 Very High Very High Very High
Cancer 722 99.84 Very High Very High Very High
Giant Cell Tumors 92 99.84 Very High Very High Very High
Renal Cancer 6 99.84 Very High Very High Very High
Osteoporosis 128 99.80 Very High Very High Very High
Endometriosis 672 99.78 Very High Very High Very High
Fibromyalgia 8 99.72 Very High Very High Very High
Pancreatitis 21 99.68 Very High Very High Very High
Headache 12 99.68 Very High Very High Very High
Colorectal Cancer 190 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed expression of M-CSF/ CSF-1 and c-fms, with time-dependent increase in both after the addition of estrogen.
Gene_expression (expression) of CSF-1 associated with fibromyalgia
1) Confidence 0.73 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.74 Pain Relevance 0.15
We showed expression of M-CSF/ CSF-1 and c-fms, with time-dependent increase in both after the addition of estrogen.
Gene_expression (expression) of M-CSF associated with fibromyalgia
2) Confidence 0.64 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.74 Pain Relevance 0.15
The effect of estrogen was investigated through the expression of RANKL, osteoprotegerin (OPG), M-CSF/CSF-1 and c-fms.
Spec (investigated) Gene_expression (expression) of M-CSF associated with fibromyalgia
3) Confidence 0.64 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.74 Pain Relevance 0.15
Plasma levels of interleukin (IL)-8, macrophage-colony stimulating factor (M-CSF) and monocyte chemoattractant protein-1 (MCP)-1 were measured by enzyme-linked immunosorbent assay.
Gene_expression (levels) of macrophage-colony stimulating factor in monocyte
4) Confidence 0.60 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11369010 Disease Relevance 0.46 Pain Relevance 0.59
The effect of estrogen was investigated through the expression of RANKL, osteoprotegerin (OPG), M-CSF/CSF-1 and c-fms.
Spec (investigated) Gene_expression (expression) of CSF-1 associated with fibromyalgia
5) Confidence 0.57 Published 2008 Journal Int. J. Mol. Med. Section Abstract Doc Link 18506373 Disease Relevance 0.74 Pain Relevance 0.15
Plasma levels of interleukin (IL)-8, macrophage-colony stimulating factor (M-CSF) and monocyte chemoattractant protein-1 (MCP)-1 were measured by enzyme-linked immunosorbent assay.
Gene_expression (levels) of M-CSF in monocyte
6) Confidence 0.52 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11369010 Disease Relevance 0.46 Pain Relevance 0.60
Increased M-CSF expression may be involved in neointima formation at injured vessels through activation of mononuclear phagocytes.
Gene_expression (expression) of M-CSF in mononuclear phagocytes associated with neointima
7) Confidence 0.52 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11369010 Disease Relevance 0.32 Pain Relevance 0.50
There were no increased plasma levels of interleukin-6 or macrophage colony-stimulating factor (M-CSF) during rhIL-3.
Neg (no) Gene_expression (levels) of macrophage colony-stimulating factor in macrophage
8) Confidence 0.47 Published 1993 Journal Ann. Hematol. Section Abstract Doc Link 8218538 Disease Relevance 0.72 Pain Relevance 0.28
not only affected the expression of RANKL, M-CSF, and OPG in chondrocytes, but may also affect the course of cell differentiation.
Gene_expression (expression) of M-CSF in chondrocytes
9) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
M-CSF and OPG are produced and released by activated osteoblasts, chondrocytes, and fibroblasts [2, 4–6].
Gene_expression (produced) of M-CSF in osteoblasts
10) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.08
-induced M-CSF gene expression on either of the days tested (Figure 4).

3.5.

Gene_expression (expression) of M-CSF
11) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
stimulation, whereas M-CSF expression decreased (data not shown).
Gene_expression (expression) of M-CSF
12) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.05 Pain Relevance 0.03
, whereas M-CSF expression decreased.
Gene_expression (expression) of M-CSF
13) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.24 Pain Relevance 0.12
showed the same effect for the expression of RANKL, M-CSF, and OPG for any culture period, while the control value changed in the long-term culture.
Gene_expression (expression) of M-CSF
14) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
-mediated reduction in M-CSF expression.
Gene_expression (expression) of M-CSF
15) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.05 Pain Relevance 0
is closely associated with the expression of M-CSF, RANKL, and OPG in osteoblasts and chondrocytes.
Gene_expression (expression) of M-CSF in osteoblasts
16) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.50 Pain Relevance 0.29
and celecoxib, a specific inhibitor of COX-2 [24, 25], on the expression of M-CSF, RANKL, and OPG in human chondrocytes, and the indirect effect of IL-1?
Gene_expression (expression) of M-CSF in chondrocytes
17) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.12 Pain Relevance 0.10
Therefore, these previous studies suggest that the effect of IL-1 on RANKL expression is the same in osteoblasts and chondrocytes; whereas the effect of IL-1 on OPG and M-CSF expression differs according to cell type and IL-1 subtype.
Gene_expression (expression) of M-CSF in chondrocytes
18) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
Consistent with the results obtained in the gene expression study, M-CSF protein expression was significantly lower in the presence of IL-1?
Gene_expression (expression) of M-CSF
19) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
, RANKL, M-CSF, and OPG gene expression was unaffected by the presence of celecoxib.
Gene_expression (expression) of M-CSF
20) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

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