INT46621

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.53
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSF1) cell proliferation (CSF1) extracellular space (CSF1)
extracellular region (CSF1) plasma membrane (CSF1)
Anatomy Link Frequency
macrophages 12
granulocyte 4
chondrocytes 2
plasma 2
mononuclear phagocytes 2
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 82 100.00 Very High Very High Very High
Migraine 6 99.68 Very High Very High Very High
Cluster headache 4 99.16 Very High Very High Very High
rheumatoid arthritis 35 98.60 Very High Very High Very High
endometriosis 168 97.92 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 11 97.04 Very High Very High Very High
Inflammation 126 86.88 High High
headache 3 85.84 High High
midbrain 1 84.20 Quite High
chemokine 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Colorectal Cancer 190 99.84 Very High Very High Very High
Headache 9 99.68 Very High Very High Very High
Giant Cell Tumors 23 99.34 Very High Very High Very High
Neointima 1 99.20 Very High Very High Very High
Cluster Headache 4 99.16 Very High Very High Very High
Rheumatoid Arthritis 35 98.60 Very High Very High Very High
Endometriosis 224 97.92 Very High Very High Very High
Cardiovascular Disease 4 96.80 Very High Very High Very High
Carcinoid 2 95.84 Very High Very High Very High
Cancer 133 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased M-CSF expression may be involved in neointima formation at injured vessels through activation of mononuclear phagocytes.
Positive_regulation (Increased) of Gene_expression (expression) of M-CSF in mononuclear phagocytes associated with neointima
1) Confidence 0.47 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11369010 Disease Relevance 0.33 Pain Relevance 0.50
-induced M-CSF gene expression on either of the days tested (Figure 4).

3.5.

Positive_regulation (induced) of Gene_expression (expression) of M-CSF
2) Confidence 0.39 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
There were no increased plasma levels of interleukin-6 or macrophage colony-stimulating factor (M-CSF) during rhIL-3.
Neg (no) Positive_regulation (increased) of Neg (no) Gene_expression (levels) of macrophage colony-stimulating factor in macrophage
3) Confidence 0.36 Published 1993 Journal Ann. Hematol. Section Abstract Doc Link 8218538 Disease Relevance 0.73 Pain Relevance 0.28
Tanabe et al. [2] reported that conditioned medium containing M-CSF and PGE2 produced by IL-1?
Positive_regulation (medium) of Gene_expression (containing) of M-CSF
4) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.09 Pain Relevance 0
suppresses the formation of osteoclast-like cells via an increase in OPG production and a decrease in M-CSF production, at least in part, in the human chondrocytes used in this study, and that OPG production may increase through an autocrine mechanism involving celecoxib-related PGs.
Positive_regulation (increase) of Gene_expression (production) of M-CSF in chondrocytes
5) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.07 Pain Relevance 0
On the other hand, M-CSF expression in osteoblasts increased after stimulation with IL-1?
Positive_regulation (increased) of Gene_expression (expression) of M-CSF in osteoblasts
6) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.07 Pain Relevance 0.04
Presumably the stromal cells are the source of m-CSF, akin to the situation in localized and diffuse giant cell tumors of tendon sheath/synovium where m-CSF is overexpressed by the neoplastic cells, sometimes secondary to a recurrent translocation[10,11].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of m-CSF in stromal cells associated with giant cell tumors
7) Confidence 0.26 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954972 Disease Relevance 0.73 Pain Relevance 0
The serum levels of both macrophage-colony stimulating factor (M-CSF) and granulocyte-colony stimulating factor are significantly higher in CRC patients than in healthy subjects [79,80].
Positive_regulation (higher) of Gene_expression (levels) of macrophage-colony stimulating factor in granulocyte associated with colorectal cancer
8) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.70 Pain Relevance 0
The serum levels of both macrophage-colony stimulating factor (M-CSF) and granulocyte-colony stimulating factor are significantly higher in CRC patients than in healthy subjects [79,80].
Positive_regulation (higher) of Gene_expression (levels) of M-CSF in granulocyte associated with colorectal cancer
9) Confidence 0.22 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.70 Pain Relevance 0
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of Gene_expression (produce) of macrophage colony stimulating factor in macrophages associated with cytokine
10) Confidence 0.19 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of Gene_expression (produce) of M-CSF in macrophages associated with cytokine
11) Confidence 0.17 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
The following results were obtained: (a) no significant difference in the time course of free and total TP after l-TP intravenous loading, (b) increased levels of CSF TP during migraine and cluster headache attacks, (c) impressively increased levels of plasma 5-HT only in carcinoid patients.
Positive_regulation (increased) of Gene_expression (levels) of CSF TP in plasma associated with cluster headache, carcinoid and migraine
12) Confidence 0.13 Published 1982 Journal Adv Neurol Section Abstract Doc Link 7055005 Disease Relevance 0.96 Pain Relevance 0.97
Increased cell counts may be attributable to elevated levels of macrophage colony-stimulating factor (M-CSF) [31] and monocyte chemotactic protein (MCP)-1 [32] (Fig. 1).
Positive_regulation (elevated) of Gene_expression (levels) of M-CSF in monocyte
13) Confidence 0.07 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.69 Pain Relevance 0.26
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of in stem cells Gene_expression (produce) of macrophage colony stimulating factor in macrophages associated with cytokine
14) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of in neutrophils Gene_expression (produce) of macrophage colony stimulating factor in macrophages associated with cytokine
15) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of in stem cells Gene_expression (produce) of M-CSF in macrophages associated with cytokine
16) Confidence 0.06 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of in neutrophils Gene_expression (produce) of M-CSF in macrophages associated with cytokine
17) Confidence 0.06 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
Key molecules for osteoclast differentiation are macrophage colony stimulating factor and RANKL, which are both expressed locally in the synovial tissue of RA patients, enabling full differentiation of osteoclasts [11-14].
Positive_regulation (macrophage) of Gene_expression (expressed) of colony stimulating factor in macrophage associated with rheumatoid arthritis
18) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860063 Disease Relevance 0.52 Pain Relevance 0.25

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