INT4663

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 9.48
Pain Relevance 7.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) aging (Ada)
cell adhesion (Ada) plasma membrane (Ada) lysosome (Ada)
Anatomy Link Frequency
cerebrospinal fluid 3
sputum 1
pleural fluid 1
erythrocytes 1
spinal cord 1
Ada (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 111 100.00 Very High Very High Very High
Inflammation 30 99.42 Very High Very High Very High
antagonist 12 98.54 Very High Very High Very High
Potency 2 97.52 Very High Very High Very High
antinociception 1 97.20 Very High Very High Very High
Angina 13 96.98 Very High Very High Very High
Arthritis 27 96.88 Very High Very High Very High
Spinal cord 4 96.80 Very High Very High Very High
Serotonin 5 96.78 Very High Very High Very High
Clonidine 1 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pleural Effusion 2 99.88 Very High Very High Very High
Meningoencephalitis 12 99.66 Very High Very High Very High
INFLAMMATION 36 99.42 Very High Very High Very High
Leukocytosis 3 99.32 Very High Very High Very High
Malignant Pleural Effusion 6 99.00 Very High Very High Very High
Agammaglobulinemia 3 98.90 Very High Very High Very High
Mycobacterial Infection 8 98.44 Very High Very High Very High
Bacterial Respiratory Disease 1 98.40 Very High Very High Very High
Dyspnea 1 98.28 Very High Very High Very High
Angina 1 96.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Forty-eight cases of tuberculous pleurisy were examined and the following results were obtained. (1) Most of the patients were male, and there was no significant age and underlying diseases. (2) Fever and chest pain were observed mainly in younger patients, and sputum and dyspnea in older patients. (3) All of the cases examined had exudative pleural effusion, and increased ADA activity was frequently observed. (4) Mycobacterium tuberculosis was detected in the sputum of 65%, and also in the pleural effusion of 28% of the patients.
Positive_regulation (increased) of ADA in sputum associated with mycobacterial infection, pleural effusion, angina, pleural tuberculosis, dyspnea, fever and disease
1) Confidence 0.69 Published 1992 Journal Kekkaku Section Abstract Doc Link 1434315 Disease Relevance 1.22 Pain Relevance 0.10
A region which included the hypothalamus had the highest AMP deaminase and adenosine deaminase activities, while its 5'-nucleotidase activities were relatively low.
Positive_regulation (had) of adenosine deaminase in hypothalamus associated with adenocard
2) Confidence 0.47 Published 1976 Journal J. Neurobiol. Section Abstract Doc Link 1262867 Disease Relevance 0 Pain Relevance 0.11
Surprisingly, bath samples collected after stimulating the LM-MP exhibited a relatively high adenosine deaminase (ADA) activity (0.60+/-0.07 U ml-1), which increased in parallel with the accumulation of adenosine and its deamination products.
Positive_regulation (increased) of ADA associated with adenocard
3) Confidence 0.45 Published 2006 Journal Auton Neurosci Section Abstract Doc Link 16563876 Disease Relevance 0 Pain Relevance 0.56
We describe the development of enterovirus meningoencephalitis associated with increased adenosine deaminase in cerebrospinal fluid of a 12-year-old boy, a known case of hypogamaglobulinemia despite monthly replacement of IVIg.The patient was referred to our center with fever, headache and vomiting for 10 days.
Positive_regulation (increased) of adenosine deaminase in cerebrospinal fluid associated with adenocard, vomiting, meningoencephalitis, headache and fever
4) Confidence 0.41 Published 2009 Journal Iran J Allergy Asthma Immunol Section Abstract Doc Link 19671942 Disease Relevance 0.73 Pain Relevance 0.22
A case of hypogammaglobulinemia with enteroviral meningoencephalitis, associated with increased adenosine deaminase in cerebrospinal fluid.
Positive_regulation (increased) of adenosine deaminase in cerebrospinal fluid associated with adenocard, meningoencephalitis and agammaglobulinemia
5) Confidence 0.41 Published 2009 Journal Iran J Allergy Asthma Immunol Section Title Doc Link 19671942 Disease Relevance 0.79 Pain Relevance 0.23
For patients with increased ADA and lymphocytic pleocytosis in CSF, differential diagnoses should include enteroviral meningitis.
Positive_regulation (increased) of ADA associated with meningitis and leukocytosis
6) Confidence 0.36 Published 2009 Journal Iran J Allergy Asthma Immunol Section Abstract Doc Link 19671942 Disease Relevance 0.86 Pain Relevance 0.21
The expression of the ADA and XO genes in those tissues returned to the control level during morphine withdrawal, with the exception of the skeletal muscles; and (v) the upregulation of the expression of the ADA and XO genes induced by morphine treatment could be reversed by naloxone.
Positive_regulation (induced) of ADA in skeletal muscles
7) Confidence 0.21 Published 2007 Journal Acta Pharmacol. Sin. Section Body Doc Link 17640470 Disease Relevance 0 Pain Relevance 0
The activity of adenosine deaminase (ADA) in plasma increased by 6%, but in granulocytes, lymphocytes and erythrocytes decreased by about 24, 19 and 10.6%, respectively.
Positive_regulation (increased) of adenosine deaminase in lymphocytes associated with adenocard
8) Confidence 0.17 Published 1997 Journal Haematologia (Budap) Section Abstract Doc Link 9408766 Disease Relevance 0.56 Pain Relevance 0.57
The dichotomy between the high adenosine levels in the inflamed tissues and the inability of adenosine to hamper the inflammatory process is explained by the increased adenosine deaminase level in this environment [10].
Positive_regulation (increased) of adenosine deaminase associated with adenocard and inflammation
9) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526584 Disease Relevance 0.96 Pain Relevance 1.09
In this study, we evaluated the relative contribution of adenosine kinase and adenosine deaminase to the regulation of adenosine release into the extracellular space within the spinal cord by determining the effects of the adenosine kinase inhibitors 5'-amino-5'-deoxyadenosine and 5-iodotubercidin, and the adenosine deaminase inhibitor 2'-deoxycoformycin on adenosine release from spinal cord slices in an in vitro perfusion system.
Positive_regulation (contribution) of adenosine deaminase in spinal cord associated with adenocard and spinal cord
10) Confidence 0.07 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8832217 Disease Relevance 0 Pain Relevance 0.72
The hypothesis that endogenous adenosine influences hippocampal serotonin release is supported by the following findings: both the adenosine receptor antagonists (theophylline or 8-phenyltheophylline (10 microM, each)) and the enzyme adenosine deaminase (10 micrograms/ml) increased, whereas R-E 244 (3 microM), an inhibitor of adenosine uptake, significantly decreased the evoked tritium overflow.
Positive_regulation (increased) of adenosine deaminase associated with adenocard, antagonist and serotonin
11) Confidence 0.06 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2984005 Disease Relevance 0 Pain Relevance 0.91
The activity of adenosine deaminase (ADA) in plasma increased by 6%, but in granulocytes, lymphocytes and erythrocytes decreased by about 24, 19 and 10.6%, respectively.
Positive_regulation (increased) of adenosine deaminase in granulocytes associated with adenocard
12) Confidence 0.06 Published 1997 Journal Haematologia (Budap) Section Abstract Doc Link 9408766 Disease Relevance 0.56 Pain Relevance 0.57
The activity of adenosine deaminase (ADA) in plasma increased by 6%, but in granulocytes, lymphocytes and erythrocytes decreased by about 24, 19 and 10.6%, respectively.
Positive_regulation (increased) of adenosine deaminase in erythrocytes associated with adenocard
13) Confidence 0.06 Published 1997 Journal Haematologia (Budap) Section Abstract Doc Link 9408766 Disease Relevance 0.56 Pain Relevance 0.57
Indirect mechanisms increasing the extracellular concentration of adenosine using adenosine kinase inhibitors, adenosine deaminase inhibitors or adenosine uptake inhibitors, or increasing the potency of adenosine at the A(1) receptor subtype by allosteric modulators lead to potent antinociceptive and antiinflammatory activity.
Positive_regulation (using) of adenosine deaminase associated with adenocard, inflammation, antinociceptive and potency
14) Confidence 0.03 Published 2006 Journal Curr Top Med Chem Section Abstract Doc Link 16918456 Disease Relevance 1.28 Pain Relevance 1.44
To identify dietary influences that selectively affect insulin action the effects of insulin were compared with those of other antilipolytic agents in the presence of adenosine deaminase.
Positive_regulation (presence) of adenosine deaminase associated with adenocard
15) Confidence 0.03 Published 1987 Journal Int J Obes Section Abstract Doc Link 3301711 Disease Relevance 0.60 Pain Relevance 0.29
Routine systemic bacterial, tuberculous and viral analyses all resulted in negative study except for increase of adenosine deaminase in CSF.
Neg (except) Positive_regulation (increase) of adenosine deaminase in CSF associated with adenocard
16) Confidence 0.02 Published 2009 Journal Rinsho Shinkeigaku Section Abstract Doc Link 19715172 Disease Relevance 0.54 Pain Relevance 0.17
Increased pleural fluid adenosine deaminase levels in patients with malignant pleural effusions: a potential predictor of talc pleurodesis outcome.
Positive_regulation (Increased) of pleural fluid adenosine deaminase in pleural fluid associated with adenocard and malignant pleural effusion
17) Confidence 0.01 Published 2007 Journal Lung Section Title Doc Link 17952507 Disease Relevance 0.83 Pain Relevance 0.18

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