INT46632

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1982
Last Reported 2001
Negated 3
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.05
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
brain 2
locus coeruleus 2
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 4 100.00 Very High Very High Very High
Locus ceruleus 8 99.68 Very High Very High Very High
Serotonin 2 98.36 Very High Very High Very High
Dopamine 10 97.92 Very High Very High Very High
Morphine 4 83.52 Quite High
tetrodotoxin 3 55.12 Quite High
Disease Link Frequency Relevance Heat
Stress 1 51.72 Quite High
Pressure And Volume Under Development 2 46.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Idazoxan and morphine inhibited whole brain homogenate MAO-B activity in a dose-dependent manner, while agmatine, an endogenous imidazoline ligand, didn't affect the activity of MAO-B, and it had no effect on the inhibition of MAO-B activity by idazoxan or morphine.
Neg (no) Regulation (effect) of Negative_regulation (inhibition) of MAO-B in brain
1) Confidence 0.62 Published 2001 Journal Acta Pharmacol. Sin. Section Body Doc Link 11749830 Disease Relevance 0 Pain Relevance 0
Effects of local MAO inhibition in the locus coeruleus on extracellular serotonin and 5-HIAA during exposure to sensory and cardiovascular stimuli.
Regulation (Effects) of Negative_regulation (inhibition) of MAO in locus coeruleus associated with locus ceruleus and serotonin
2) Confidence 0.45 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10208305 Disease Relevance 0.05 Pain Relevance 0.49
The increased 3-MT turnover rate that was observed after amphetamine treatment suggests that monoamine oxidase (MAO) inhibition is no explanation for the mechanism of interaction of this drug with dopamine (DA) metabolism.
Neg (no) Regulation (explanation) of Negative_regulation (inhibition) of monoamine oxidase associated with dopamine and monoamine
3) Confidence 0.45 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7057187 Disease Relevance 0 Pain Relevance 0.34
The increased 3-MT turnover rate that was observed after amphetamine treatment suggests that monoamine oxidase (MAO) inhibition is no explanation for the mechanism of interaction of this drug with dopamine (DA) metabolism.
Neg (no) Regulation (explanation) of Negative_regulation (inhibition) of MAO associated with dopamine and monoamine
4) Confidence 0.45 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 7057187 Disease Relevance 0 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox