INT46637

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Context Info
Confidence 0.78
First Reported 1982
Last Reported 2011
Negated 1
Speculated 5
Reported most in Body
Documents 172
Total Number 192
Disease Relevance 121.94
Pain Relevance 57.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
fibroblasts 16
T cells 11
monocytes 8
plasma 6
tears 6
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 3759 100.00 Very High Very High Very High
cytokine 3186 100.00 Very High Very High Very High
Inflammation 2121 100.00 Very High Very High Very High
pulpitis 10 99.92 Very High Very High Very High
Arthritis 1889 99.88 Very High Very High Very High
Fibrositis 194 99.84 Very High Very High Very High
rheumatoid arthritis 1539 99.78 Very High Very High Very High
opioid receptor 2 99.74 Very High Very High Very High
agonist 118 99.70 Very High Very High Very High
spinal inflammation 553 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2378 100.00 Very High Very High Very High
Cancer 587 100.00 Very High Very High Very High
Necrosis 264 100.00 Very High Very High Very High
Apoptosis 193 100.00 Very High Very High Very High
Hypersensitivity 57 100.00 Very High Very High Very High
Skin Cancer 16 100.00 Very High Very High Very High
Infection 1833 99.96 Very High Very High Very High
Pulpitis 10 99.92 Very High Very High Very High
Arthritis 1069 99.88 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 69 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of upstream apoptotic regulators like pJNK, p38 and Bax was established on the basis of their increased expression of CXCL10.
Gene_expression (expression) of CXCL10 associated with apoptosis
1) Confidence 0.78 Published 2010 Journal Int J Exp Pathol Section Abstract Doc Link 20041963 Disease Relevance 1.15 Pain Relevance 0.12
Typical heat patterns have been observed in root compression syndromes and particularly at the S-1, L-5, L-4, C-6, C-7, and C-8 levels.
Gene_expression (levels) of C-7 associated with syndrome
2) Confidence 0.75 Published 1982 Journal J. Neurosurg. Section Abstract Doc Link 7057236 Disease Relevance 0.25 Pain Relevance 0.18
CXCL10 and interleukin-8) expression was observed in both microglia and astrocytes (p<0.05).
Gene_expression (expression) of CXCL10 in astrocytes
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2943470 Disease Relevance 2.68 Pain Relevance 0.21
It is plausible that the increased expression of CXCL10 and CXCL8 by HCV core-exposed microglia and astrocytes might enhance recruitment of T helper cells and monocytes in the brain, leading to deleterious effects.
Gene_expression (expression) of CXCL10 in astrocytes associated with hepatitis c virus infection
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.23 Pain Relevance 0.05
Increased expression of CXCL10 and CXCL8 in astrocytes was also reported in brains of individuals with HIV encephalitis [64].
Gene_expression (expression) of CXCL10 in brains associated with acquired immune deficiency syndrome or hiv infection and viral meningitis
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943470 Disease Relevance 1.45 Pain Relevance 0.06
were rather weak inducers of CXCL10 (1–5 ng/ml) in fibroblasts as single agents, all combinations provided a dose-dependent synergistic induction yielding a 3-fold to 30-fold increase of CXCL10 production (5–150 ng/ml) (Figures 1 and 2, left panels).
Gene_expression (production) of CXCL10 in fibroblasts
6) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.13 Pain Relevance 0.17
was the most potent stimulus of CXCL10 production in HMVEC and fibroblasts.
Gene_expression (production) of CXCL10 in fibroblasts
7) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.64 Pain Relevance 0.60
to drastically enhance the production of CXCL10 by fibroblasts and to inhibit IFN-?
Gene_expression (production) of CXCL10 in fibroblasts
8) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.22 Pain Relevance 0.23
Levels of human CXCL8 and CXCL10 were quantified by specific sandwich ELISAs developed in our laboratory as previously described [22].
Gene_expression (Levels) of CXCL10
9) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.05
resulted in more than 10-fold increased CXCL10 protein production.
Gene_expression (production) of CXCL10 protein
10) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.23 Pain Relevance 0.35
Together with the expression of CXCL10, the expression of membrane-bound CD26/dipeptidyl peptidase IV was also upregulated in fibroblasts by IFN-?
Gene_expression (expression) of CXCL10 in fibroblasts
11) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1779382 Disease Relevance 0.96 Pain Relevance 0.67
to produce CXCL10 and provoke a selective infiltration of activated Th1 lymphocytes and natural killer cells.
Gene_expression (produce) of CXCL10 in natural killer cells
12) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.75 Pain Relevance 0.58
The CXCL8 and CXCL10 production, however, was much higher in HMVEC than in fibroblast cultures.
Gene_expression (production) of CXCL10 in fibroblast
13) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.16
resulted in a more modest synergistic increase of CXCL10 production.
Gene_expression (production) of CXCL10
14) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.07 Pain Relevance 0.21
The lining endothelial cells of capillaries, in direct contact with the target leukocytes in the bloodstream, are therefore an important CXCL8 and CXCL10 source.
Gene_expression (source) of CXCL10 in endothelial cells
15) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0 Pain Relevance 0.12
to produce a comparable amount of CXCL10.
Gene_expression (produce) of CXCL10
16) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.49 Pain Relevance 0.51
did not induce CXCL10 production in fibroblasts or HMVEC, the combined treatment of these cells with IFN-?
Gene_expression (production) of CXCL10 in fibroblasts
17) Confidence 0.68 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779382 Disease Relevance 0.47 Pain Relevance 0.51
Cytokine IP-10 (CXCL10) was found to be present in the highest concentration of all tested cytokines.
Gene_expression (present) of CXCL10 associated with cytokine
18) Confidence 0.67 Published 2010 Journal Respir Res Section Body Doc Link PMC2923116 Disease Relevance 0.10 Pain Relevance 0.27
Immunostaining results revealed that CXCL10 was detected in macrophages, endothelial cells, and fibroblasts in inflamed dental pulp, and that CXCR3 expression was observed mainly on T-cells.
Gene_expression (detected) of CXCL10 in fibroblasts
19) Confidence 0.66 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.33 Pain Relevance 0.47
, IL-2, IL-4, IL-5, IL-13, IL-17, MIG, and IP-10) were excluded from our analysis due to weak signal in both pre- and post- S. aureus stimulated supernatant (5 cytokines); lack of response to S. aureus (2 cytokines), and cross-contamination (2 cytokines) (Figure S5).
Neg (lack) Gene_expression (excluded) of IP-10 associated with cytokine
20) Confidence 0.65 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0 Pain Relevance 0.51

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