INT46646

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Context Info
Confidence 0.73
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 18.83
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FLNA) extracellular region (FLNA) plasma membrane (FLNA)
nucleus (FLNA) transcription factor binding (FLNA) cytoplasm (FLNA)
Anatomy Link Frequency
blood 1
endothelial cell 1
smooth muscle cell 1
endothelium 1
internal 1
FLNA (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 12 100.00 Very High Very High Very High
imagery 51 99.80 Very High Very High Very High
Bioavailability 11 99.64 Very High Very High Very High
headache 18 96.72 Very High Very High Very High
ischemia 16 94.72 High High
corticosteroid 21 92.00 High High
rheumatoid arthritis 95 90.44 High High
Inflammation 88 89.84 High High
Migraine 27 89.44 High High
Calcium channel 2 87.52 High High
Disease Link Frequency Relevance Heat
Fibromuscular Dyplasia 360 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 256 100.00 Very High Very High Very High
Cardiovascular Disease 186 100.00 Very High Very High Very High
Hyperemia 57 100.00 Very High Very High Very High
Metabolic Syndrome 47 100.00 Very High Very High Very High
Stress 41 100.00 Very High Very High Very High
Migraine With Aura 27 100.00 Very High Very High Very High
Aneurism 22 99.90 Very High Very High Very High
Nicotine Addiction 42 99.60 Very High Very High Very High
Syndrome 23 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is an exceptional need for health care practitioners to recognize the importance of MetS and CVD among the South Asian migrant community, especially given the populationÂ’s rapid growth.
Localization (importance) of CVD associated with cardiovascular disease and metabolic syndrome
1) Confidence 0.73 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2742703 Disease Relevance 0.56 Pain Relevance 0
Although the etiology of FMD is not well understood, several mechanisms have been proposed, such as genetic predisposition, hormonal factors, and arterial wall ischemia.
Localization (etiology) of FMD associated with fibromuscular dyplasia, ischemia and genetic predisposition to disease
2) Confidence 0.64 Published 2008 Journal Brain Nerve Section Abstract Doc Link 18975600 Disease Relevance 1.43 Pain Relevance 0.14
FMD of the internal carotid and vertebral arteries usually occurs in the extracranial portions and is mostly observed at the level of the second cervical vertebra.
Localization (observed) of FMD in internal associated with fibromuscular dyplasia
3) Confidence 0.64 Published 2008 Journal Brain Nerve Section Abstract Doc Link 18975600 Disease Relevance 1.12 Pain Relevance 0.07
The aneurysms found in 19 patients had conventional appearance and were mainly located in the internal carotid or middle cerebral arteries and on the same side as the most affected cervical artery, which suggests that aneurysms and FMD are pathogenically related.
Localization (related) of FMD in cervical artery associated with fibromuscular dyplasia and aneurism
4) Confidence 0.63 Published 1982 Journal Stroke Section Abstract Doc Link 7064180 Disease Relevance 1.61 Pain Relevance 0.18
Management of dissecting carotid artery FMD includes anticoagulation and, in cases with expanding or symptomatic pseudoanevrysm, percutaneous angioplasty or surgical repair [43].
Localization (dissecting) of FMD in carotid artery associated with fibromuscular dyplasia
5) Confidence 0.61 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 1.40 Pain Relevance 0.04
The mechanisms by which smoking contributes to the etiology of FMD have, however, not been elucidated.
Localization (etiology) of FMD associated with fibromuscular dyplasia and nicotine addiction
6) Confidence 0.61 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1899482 Disease Relevance 2.37 Pain Relevance 0.23
Decreased percentage FMD showed a close correlation with the disease duration, systolic blood pressure, and inflamatory parameters (hs-CRP and ESR).
Localization (Decreased) of FMD in blood associated with disease and increased venous pressure under development
7) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 1.87 Pain Relevance 0.09
We assume that decreased FMD may occur as a result of continuous endothelial cell activation and impairment.
Localization (decreased) of FMD in endothelial cell associated with increased venous pressure under development
8) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911856 Disease Relevance 2.07 Pain Relevance 0.08
At the same time, the FMD marker of both shear-stress-induced NO release and its bioavailability was impaired.
Localization (release) of FMD associated with stress, increased venous pressure under development and bioavailability
9) Confidence 0.26 Published 2009 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2852773 Disease Relevance 0.78 Pain Relevance 0.08
There was no significant association of NTGMD with PM2.5 on the same day, suggesting that the decrease in FMD with increased PM2.5 is endothelium dependent and does not reflect increased smooth muscle cell reactivity.
Localization (decrease) of FMD in smooth muscle cell
10) Confidence 0.25 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0 Pain Relevance 0
The estimates given in Table 4 correspond to an absolute mean change in FMD (lag 0) per 10-?
Localization (change) of FMD
11) Confidence 0.25 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0 Pain Relevance 0
FMD is a measure of endothelial-dependent vasomotion and is due largely to endothelial release of NO, whereas the endothelium-independent dilatation observed in response to nitroglycerin reflects vascular reactivity to an exogenous NO donor.
Localization (release) of FMD in endothelium
12) Confidence 0.25 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.28 Pain Relevance 0.04
In this subgroup, they found the strongest decrease of FMD associated with a 6-day moving-average exposure of sulfates and black carbon; the effect estimates for PM2.5 and particle number count were a little smaller and not statistically significant.
Localization (decrease) of FMD
13) Confidence 0.25 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.41 Pain Relevance 0
Fluorescent studies, using confocal microscopy, provided evidence that filamin and mu opioid receptors were extensively colocalized on the membranes of filamin-expressing melanoma cells.
Localization (colocalized) of filamin associated with mu opioid receptor and skin cancer
14) Confidence 0.22 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.19 Pain Relevance 0.51
In fact, a high FMD in patients with MwA could be the result of either an increased release of NO induced by shear stress (nearly impossible to measure locally) or of an arterial super-sensitivity to NO.
Localization (release) of FMD associated with stress, migraine with aura and hyperemia
15) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2848147 Disease Relevance 0.98 Pain Relevance 0.12
Due to the unfavourable localisation of FMD for CDI, the sensitivity of CDI is low in comparison to angiography.
Localization (localisation) of FMD associated with fibromuscular dyplasia and imagery
16) Confidence 0.09 Published 2004 Journal Cardiovasc Ultrasound Section Body Doc Link PMC493280 Disease Relevance 1.08 Pain Relevance 0.33
Due to the unfavourable localisation of FMD for CDI, the sensitivity of CDI is lower in comparison to angiography.
Localization (localisation) of FMD associated with fibromuscular dyplasia and imagery
17) Confidence 0.09 Published 2004 Journal Cardiovasc Ultrasound Section Abstract Doc Link PMC493280 Disease Relevance 1.45 Pain Relevance 0.42
Secondly, it has been documented that the value of FMD measurement may be affected considerably by life style habits, such as recent physical activity, smoking, and food intake, technical aspects of the measurement, such as cuff location, and concomitant drug treatment, such as statins [45–48].
Localization (measurement) of FMD associated with nicotine addiction and increased venous pressure under development
18) Confidence 0.03 Published 2007 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2039813 Disease Relevance 0.46 Pain Relevance 0
Regarding endothelial biomarkers, IMT was significantly related to tPA-mass, VWF, sL-selectin and MCP-1 and ED-FMD was significantly related to PAI-1 and sL-selectin (Table 4).
Localization (sL-selectin) of ED-FMD
19) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 0.77 Pain Relevance 0.19

General Comments

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