INT46691

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Context Info
Confidence 0.50
First Reported 1982
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 3.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN9A)
SCN9A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 5 100.00 Very High Very High Very High
tetrodotoxin 14 99.84 Very High Very High Very High
Mexiletine 4 99.30 Very High Very High Very High
IPN 2 99.16 Very High Very High Very High
lidocaine 2 99.00 Very High Very High Very High
Pain 142 96.32 Very High Very High Very High
nociceptor 5 95.48 Very High Very High Very High
addiction 2 93.08 High High
sodium channel 21 92.16 High High
Neuropathic pain 4 83.40 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Pain 2 99.16 Very High Very High Very High
Pain 148 96.32 Very High Very High Very High
Targeted Disruption 7 91.60 High High
Neuropathic Pain 8 83.40 Quite High
INFLAMMATION 8 82.56 Quite High
Nociception 13 81.40 Quite High
Erythermalgia 1 59.36 Quite High
Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Then, the level of mRNA (SCN9A) encoding I(Na) decreased significantly.
Negative_regulation (decreased) of SCN9A
1) Confidence 0.50 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883037 Disease Relevance 0 Pain Relevance 0.11
Lidocaine and mexiletine exhibited tonic and use-dependent block of PN1 and PN3 channels.
Negative_regulation (block) of PN1 associated with mexiletine and lidocaine
2) Confidence 0.42 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.19 Pain Relevance 0.99
The recombinant human PN1 currents exhibited rapid activation and inactivation kinetics and were blocked by TTX with a half-maximal inhibitory concentration (IC50) of 32.6 nM.
Negative_regulation (blocked) of PN1 associated with tetrodotoxin
3) Confidence 0.37 Published 2003 Journal Recept. Channels Section Abstract Doc Link 14527872 Disease Relevance 0.25 Pain Relevance 0.98
Interestingly, loss of
               function SCN9A human mutants that have a defective
               NaV1.7 channel appear to be completely pain free but are otherwise
               normal. 
Negative_regulation (loss) of SCN9A associated with pain
4) Confidence 0.36 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 0.93 Pain Relevance 0.89
Neither CLON nor desmethylimipramine, a blocker of NE reuptake, had any selective effects on investigation of novel stimuli or short-term habituation showing that relative NE-DA activity can be disrupted without interfering with the behavior, However, CLON interfered with the frequency measure of long-term habituation in male gerbils but not in female gerbils at any dose used (0.0100.3 mg/kg).
Negative_regulation (disrupted) of NE-DA associated with dopamine
5) Confidence 0.01 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7079275 Disease Relevance 0 Pain Relevance 0.48

General Comments

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