INT46692

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.55
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN9A)
SCN9A (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 5 100.00 Very High Very High Very High
Nav1.7 4 100.00 Very High Very High Very High
Pain 33 99.12 Very High Very High Very High
Hyperalgesia 1 96.12 Very High Very High Very High
Paroxysmal extreme pain disorder 7 91.20 High High
tetrodotoxin 2 87.04 High High
sodium channel 9 85.20 High High
nav1.8 1 81.52 Quite High
gABA 1 75.68 Quite High
Peripheral nervous system 2 75.36 Quite High
Disease Link Frequency Relevance Heat
Ataxia 1 99.76 Very High Very High Very High
Frailty 1 99.32 Very High Very High Very High
Epilepsy 3 99.28 Very High Very High Very High
Pain 50 99.12 Very High Very High Very High
Channelopathies 2 98.22 Very High Very High Very High
Convulsion 1 96.40 Very High Very High Very High
Hyperalgesia 1 96.12 Very High Very High Very High
Syndrome 7 94.72 High High
Heart Arrhythmia 1 94.12 High High
Myoclonic Epilepsies 1 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, a great percentage of Na(v)1.8+beta(1) channels is observed to enter rapidly into the slow inactivated states, in contrast to Nav1.7+beta(1) channels.
Nav1.7 Binding (enter) of associated with nav1.7
1) Confidence 0.36 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11588164 Disease Relevance 0.21 Pain Relevance 0.35
These channelopathies include genes encoding voltage-gated channels specific for sodium (SCN1A, SCN2A, SCN1B, SCN9A) and potassium (KCNQ2, KCNQ3) which account for a variety of epilepsy phenotypes ranging from mild, such as Benign familial neonatal seizures (BFNS) to severe, such as Dravet syndrome (severe myoclonic epilepsy of infancy, SMEI) and the rare and unusual syndrome paroxysmal extreme pain disorder (PEPD).
SCN9A Binding (account) of associated with somatoform disorder, epilepsy, convulsion, syndrome, myoclonic epilepsies, paroxysmal extreme pain disorder and channelopathies
2) Confidence 0.32 Published 2006 Journal Early Hum. Dev. Section Abstract Doc Link 17049761 Disease Relevance 0.87 Pain Relevance 0.13
SCN9A is associated with indifference to pain in cases with inactivating mutations [7], and the opposite phenotype, hyperalgesia, in cases of activating mutations [8, 9].
SCN9A Binding (associated) of associated with pain and hyperalgesia
3) Confidence 0.31 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.47 Pain Relevance 1.27
THe data suggest important sex dependent NE-DA interactions in mediation of long-term habituation.
NE-DA Binding (interactions) of associated with dopamine
4) Confidence 0.01 Published 1982 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7079275 Disease Relevance 0 Pain Relevance 0.38

General Comments

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