INT467

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Context Info
Confidence 0.78
First Reported 1977
Last Reported 2011
Negated 30
Speculated 24
Reported most in Abstract
Documents 1048
Total Number 1072
Disease Relevance 332.80
Pain Relevance 394.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 191
pituitary 49
melanocyte 43
brain 28
blood 20
POMC (Homo sapiens)
POMC - A2M (1) POMC - L17F (1)
Pain Link Frequency Relevance Heat
Enkephalin 2259 100.00 Very High Very High Very High
Neuropeptide 1543 100.00 Very High Very High Very High
Opioid 992 100.00 Very High Very High Very High
Inflammation 827 100.00 Very High Very High Very High
narcan 425 100.00 Very High Very High Very High
agonist 342 100.00 Very High Very High Very High
antagonist 331 100.00 Very High Very High Very High
opiate 313 100.00 Very High Very High Very High
cytokine 298 100.00 Very High Very High Very High
substance P 298 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1356 100.00 Very High Very High Very High
Adenoma 1123 100.00 Very High Very High Very High
INFLAMMATION 916 100.00 Very High Very High Very High
Syndrome 752 100.00 Very High Very High Very High
Pressure And Volume Under Development 306 100.00 Very High Very High Very High
Cv Unclassified Under Development 90 100.00 Very High Very High Very High
Hemorrhage 60 100.00 Very High Very High Very High
Shock 47 100.00 Very High Very High Very High
Natriuresis 26 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 24 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of POMC mRNA decreases when the cell lines are differentiated with retinoic acid or alpha-difluoromethylornithine.
Gene_expression (expression) of POMC mRNA
1) Confidence 0.78 Published 1991 Journal Prog. Clin. Biol. Res. Section Abstract Doc Link 2068137 Disease Relevance 0.17 Pain Relevance 0.08
In this study of 16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary-adrenal axis function, as reflected by normal levels and normal circadian rhythm of levels of beta-endorphin, ACTH and cortisol, is achieved during long-term steady state methadone maintenance treatment of former heroin addicts.
Gene_expression (levels) of ACTH in pituitary associated with methadone
2) Confidence 0.78 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319894 Disease Relevance 0 Pain Relevance 0.17
In this study of 16 well-stabilized patients, it was demonstrated that normalization of hypothalamic-pituitary-adrenal axis function, as reflected by normal levels and normal circadian rhythm of levels of beta-endorphin, ACTH and cortisol, is achieved during long-term steady state methadone maintenance treatment of former heroin addicts.
Gene_expression (levels) of beta-endorphin in pituitary associated with methadone
3) Confidence 0.78 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319894 Disease Relevance 0 Pain Relevance 0.17
Basal levels of beta-endorphin and met-enkephalin in the lumbar cerebrospinal fluid (CSF) of these patients were not different from those in pain-free control subjects.
Gene_expression (levels) of beta-endorphin in CSF associated with pain and enkephalin
4) Confidence 0.78 Published 1980 Journal Lancet Section Abstract Doc Link 6107591 Disease Relevance 0.35 Pain Relevance 0.98
In a study to test the hypothesis that defects in the metabolism of neuropeptides might be a contributing factor to human anterior pituitary tumor formation, the proenkephalin A, proopiomelanocortin (POMC), and tachykinin systems, which produce methionine enkephalin (ME), beta-endorphin (BE), and substance P (SP), respectively, were measured in patients who had a wide variety of pituitary tumors.
Gene_expression (produce) of beta-endorphin in anterior pituitary associated with pituitary cancer, neuropeptide, enkephalin and substance p
5) Confidence 0.78 Published 1993 Journal Biol. Mass Spectrom. Section Abstract Doc Link 8381675 Disease Relevance 0.39 Pain Relevance 0.80
The aim of the present study was to evaluate whether adrenocorticotropic hormone, which in pituitary cells is synthesized from proopiomelanocortin such as beta-endorphin and beta-lipotropin, is also present in follicular fluid and the possible changes of proopiomelanocortin-related peptides during the menstrual cycle.
Gene_expression (synthesized) of adrenocorticotropic hormone in pituitary
6) Confidence 0.78 Published 1987 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3037909 Disease Relevance 0 Pain Relevance 0.38
The aim of the present study was to evaluate whether adrenocorticotropic hormone, which in pituitary cells is synthesized from proopiomelanocortin such as beta-endorphin and beta-lipotropin, is also present in follicular fluid and the possible changes of proopiomelanocortin-related peptides during the menstrual cycle.
Gene_expression (synthesized) of beta-lipotropin in pituitary
7) Confidence 0.78 Published 1987 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 3037909 Disease Relevance 0 Pain Relevance 0.38
These findings indicate that increased levels of beta-endorphin in cerebrospinal fluid are not directly associated with patient report of pain relief following periventricular gray stimulation.
Gene_expression (levels) of beta-endorphin in cerebrospinal fluid associated with pain
8) Confidence 0.78 Published 1984 Journal Pain Section Abstract Doc Link 6097857 Disease Relevance 0.17 Pain Relevance 0.37
Met-enkephalin and preproenkephalin were detected in the cytoplasm and cell processes of all tumors.
Gene_expression (detected) of Met-enkephalin associated with cancer and enkephalin
9) Confidence 0.78 Published 1993 Journal Cancer Res. Section Abstract Doc Link 8402649 Disease Relevance 1.14 Pain Relevance 0.55
Detection of beta-endorphin in human blood.
Gene_expression (Detection) of beta-endorphin in blood
10) Confidence 0.78 Published 1992 Journal Arch. Pathol. Lab. Med. Section Title Doc Link 1497463 Disease Relevance 0 Pain Relevance 0.18
Patient 1 was found to be a compound heterozygote for two mutations in exon 3 (G7013T, C7133delta) which interfere with appropriate synthesis of ACTH and alpha-MSH.
Gene_expression (synthesis) of alpha-MSH
11) Confidence 0.78 Published 1998 Journal Nat. Genet. Section Abstract Doc Link 9620771 Disease Relevance 0.40 Pain Relevance 0.06
Patient 1 was found to be a compound heterozygote for two mutations in exon 3 (G7013T, C7133delta) which interfere with appropriate synthesis of ACTH and alpha-MSH.
Gene_expression (synthesis) of ACTH
12) Confidence 0.78 Published 1998 Journal Nat. Genet. Section Abstract Doc Link 9620771 Disease Relevance 0.40 Pain Relevance 0.06
These data suggest that intravenous beta-endorphin can produce changes in the central nervous system in humans.
Gene_expression (produce) of beta-endorphin in central nervous system associated with central nervous system
13) Confidence 0.78 Published 1979 Journal Psychiatry Res Section Abstract Doc Link 298341 Disease Relevance 0.08 Pain Relevance 0.22
The effect on behavior of synthetic human beta-Endorphin injected into the cerebral ventricles of the cat was investigated in these experiments. beta-endorphin produced psychomotor excitation (i.e., restlessness, apprehension, flight and locomotion), accompanied by pupillary dilatation and tremor.
Gene_expression (produced) of beta-endorphin in ventricles associated with tremor and akathisia
14) Confidence 0.78 Published 1982 Journal Physiol. Behav. Section Abstract Doc Link 6281817 Disease Relevance 0.38 Pain Relevance 0.03
The expression of beta-endorphin was studied in 84 human breast cyst fluids from gross cystic breast disease-affected patients.
Gene_expression (expression) of beta-endorphin associated with fibrocystic breast disease and breast cyst
15) Confidence 0.78 Published 1995 Journal Cancer Lett. Section Abstract Doc Link 7889528 Disease Relevance 0.73 Pain Relevance 0.16
On autopsy ectopic ACTH production in the prostate was confirmed.
Gene_expression (production) of ACTH
16) Confidence 0.78 Published 1993 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8258941 Disease Relevance 1.08 Pain Relevance 0.16
Ten specimens needle biopsy of the prostate showed poorly differentiated adenocarcinoma, thus patient was diagnosed as prostate cancer with bone metastasis (stage D2) and perhaps ectopic ACTH production.
Gene_expression (production) of ACTH associated with adenocarcinoma, prostate cancer and metastasis
17) Confidence 0.78 Published 1993 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8258941 Disease Relevance 1.13 Pain Relevance 0.16
This study demonstrates that aberrant regulation of POMC synthesis and peptide processing can be seen in tumors which synthesize a POMC RNA identical in size to that made in the pituitary gland.
Gene_expression (synthesize) of POMC RNA in pituitary gland associated with cancer
18) Confidence 0.78 Published 1988 Journal Horm. Metab. Res. Section Abstract Doc Link 2456259 Disease Relevance 0.77 Pain Relevance 0.16
Des-acetylated salmon endorphin and turkey beta-endorphin have been synthesized by the solid-phase method.
Gene_expression (synthesized) of salmon endorphin
19) Confidence 0.78 Published 1980 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6254897 Disease Relevance 0 Pain Relevance 0.10
Des-acetylated salmon endorphin and turkey beta-endorphin have been synthesized by the solid-phase method.
Gene_expression (synthesized) of beta-endorphin
20) Confidence 0.78 Published 1980 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 6254897 Disease Relevance 0 Pain Relevance 0.10

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