INT46713

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Context Info
Confidence 0.35
First Reported 1982
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.35
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNC1)
Anatomy Link Frequency
cardiac myocytes 1
chest 1
thin filament 1
nociceptors 1
TNNC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 13 100.00 Very High Very High Very High
nociceptor 9 99.96 Very High Very High Very High
Angina 45 99.46 Very High Very High Very High
Hyperalgesia 5 97.52 Very High Very High Very High
beta blocker 5 81.08 Quite High
ischemia 25 79.36 Quite High
agonist 10 78.32 Quite High
c fibre 1 70.76 Quite High
Inflammation 21 70.64 Quite High
Inflammatory marker 2 63.92 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 498 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
Angina 45 99.46 Very High Very High Very High
Acute Coronary Syndrome 73 99.32 Very High Very High Very High
Emergencies 8 98.92 Very High Very High Very High
Hyperalgesia 5 97.52 Very High Very High Very High
Low Cardiac Output 27 97.16 Very High Very High Very High
Congenital Anomalies 13 93.72 High High
Heart Rate Under Development 31 90.64 High High
Injury 20 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used multivariable analysis to examine the association between elevated cTn and MI with mortality.
cTn Spec (examine) Binding (association) of associated with myocardial infarction
1) Confidence 0.35 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.75 Pain Relevance 0.08
Levosimendan is a new inodilator that exerts its inotropic effect by interacting with troponin C (the binding protein for calcium) to enhance the calcium sensitivity of cardiac myocytes.
troponin C Binding (interacting) of in cardiac myocytes
2) Confidence 0.35 Published 2005 Journal Crit Care Section Body Doc Link PMC1175868 Disease Relevance 0.48 Pain Relevance 0.07
We documented that elevated cTn levels are associated with hospital mortality, even after adjusting for other important potential confounders.
cTn Binding (associated) of
3) Confidence 0.31 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.88 Pain Relevance 0
Similar results were observed in the sensitivity analysis where inotrope and/or vasopressor use was omitted from the regression; after adjusting for illness severity and need for mechanical ventilation and haemodialysis, elevated cTn was significantly associated with hospital mortality (OR 19.7, 95 per cent CI 1.5–260.4)
cTn Binding (associated) of
4) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.65 Pain Relevance 0
Both elevated cTn and MI were associated with ICU mortality and hospital mortality in univariable analysis.
cTn Binding (associated) of associated with myocardial infarction
5) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.50 Pain Relevance 0
Elevated cTn was associated with hospital mortality (OR 27.3, 95 per cent CI 1.7–449.4), but not ICU mortality in multivariable analysis after adjusting for illness severity and need for advanced life support.
cTn Binding (associated) of
6) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2447557 Disease Relevance 0.43 Pain Relevance 0
No other type of cutaneous receptor studied exhibited changes in threshold similar to those observed for pain and for CMH nociceptors.
CMH Binding (pain) of in nociceptors associated with pain and nociceptor
7) Confidence 0.11 Published 1982 Journal J. Neurosci. Section Abstract Doc Link 7086482 Disease Relevance 1.17 Pain Relevance 1.62
OBJECTIVES: Long-term risk stratification in patients presenting with acute coronary syndromes (ACS) is possible by measuring cardiac troponin (cTn).
cardiac troponin Binding (measuring) of associated with acute coronary syndrome
8) Confidence 0.08 Published 2009 Journal Clin. Biochem. Section Abstract Doc Link 19328196 Disease Relevance 0.36 Pain Relevance 0.17
OBJECTIVES: Long-term risk stratification in patients presenting with acute coronary syndromes (ACS) is possible by measuring cardiac troponin (cTn).
cTn Binding (measuring) of associated with acute coronary syndrome
9) Confidence 0.08 Published 2009 Journal Clin. Biochem. Section Abstract Doc Link 19328196 Disease Relevance 0.36 Pain Relevance 0.17
The present study examined whether PAPP-A measured in an emergency department (ED) chest pain population in association with conventional and novel high sensitivity cTn (hs-cTnI) assays can predict long-term mortality.
cTn Binding (association) of in chest associated with angina and emergencies
10) Confidence 0.08 Published 2009 Journal Clin. Biochem. Section Abstract Doc Link 19328196 Disease Relevance 0.37 Pain Relevance 0.17
When calcium is bound to specific sites on TnC, the structure of the thin filament changes in such a manner that myosin (a molecular motor organized in muscle thick filaments) attaches to thin filaments and produces force and/or movement (Gillis TE et al. 2007).
TnC Binding (bound) of in thin filament
11) Confidence 0.04 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.40 Pain Relevance 0

General Comments

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